ICP4_PSHV1
ID ICP4_PSHV1 Reviewed; 2033 AA.
AC Q6UDF2;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 02-JUN-2021, entry version 50.
DE RecName: Full=Major viral transcription factor ICP4 homolog;
GN Name=ICP4B; Synonyms=ICP4A;
OS Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1)
OS (Pacheco's disease virus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Iltovirus.
OX NCBI_TaxID=670426;
OH NCBI_TaxID=152276; Amazona oratrix (yellow-headed parrot).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16873243; DOI=10.1128/jvi.00134-06;
RA Thureen D.R., Keeler C.L. Jr.;
RT "Psittacid herpesvirus 1 and infectious laryngotracheitis virus:
RT Comparative genome sequence analysis of two avian alphaherpesviruses.";
RL J. Virol. 80:7863-7872(2006).
CC -!- FUNCTION: This IE protein is a multifunctional protein capable of
CC migrating to the nucleus, binding to DNA, trans-activating other viral
CC genes, and autoregulating its own synthesis. It is required for the
CC switch from immediate-early to early mode of gene expression (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC -!- PTM: A long stretch of serine residues may be a major site of
CC phosphorylation. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the herpesviridae ICP4 family. {ECO:0000305}.
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DR EMBL; AY372243; AAQ73747.1; -; Genomic_DNA.
DR EMBL; AY372243; AAQ73758.1; -; Genomic_DNA.
DR RefSeq; NP_944441.1; NC_005264.1.
DR RefSeq; NP_944452.1; NC_005264.1.
DR SMR; Q6UDF2; -.
DR PRIDE; Q6UDF2; -.
DR GeneID; 2656991; -.
DR GeneID; 2657000; -.
DR KEGG; vg:2656991; -.
DR KEGG; vg:2657000; -.
DR Proteomes; UP000006840; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0039695; P:DNA-templated viral transcription; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR005206; Herpes_ICP4_N.
DR Pfam; PF03584; Herpes_ICP4_N; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Early protein; Host nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..2033
FT /note="Major viral transcription factor ICP4 homolog"
FT /id="PRO_0000406800"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 350..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1015..1064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1085..1186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1294..1342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1420..1451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1531..1612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1636..1655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1664..1718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1746..2033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..327
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1140..1156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1164..1179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1563..1579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1746..1797
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1811..1841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1855..1872
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1911..1925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2033 AA; 214895 MW; E34730A272FCC100 CRC64;
MFWHQPRQQQ LRQLQRAASG AGKHQRRSPP QTLGDDGDAA AQVPPSPTGA LLAFLNQHAS
EEGGAAAASA DGRVSVSPGF CSSILPEHSQ DLFAFSDPTS ASPQPVPMDA SLSLFTPPVP
DCGRDVGEEA EGAVAPSWRA PLPAPQWRPV HGPSWWLSSS SPSGSSRGSV TSPQYSGEET
SDAASGAPTP PPQSSGSSYV YGQALADLMA MIQEIPAPPR SVPDCRRGEP VSEDGMADRC
ETDASCYTTD EPMEAEPSEP AGGVSWLGER ADRMRADQSP RGLGAEPHVA EAGRPSSCVG
EERADVVAIA AVEERKEAAR RSPDAERNDD EEEYESLPCA QEFFTSQELA EINARAIAES
DEAEDEDAGS PAARSQSSPF PSLGPAVFVL APTSAKSSRG MRKKAIAVSR VVPDNDGEPD
PCADGPGRDH VSSAQSAGAN GALETETSVP RSATAPAGAV AACAQNTKRG YWRGAAAGHA
EEETDSDDED VLVVDVSACA EPFESFAQRQ QPRQQQHAPR NKPARQRLRA GAIVAAASGN
TLTVPSEPPH PSLAPLWKML NLWLSEEWPA QGGGQDEGEA AVSASLLAPG SLPELPDMCP
RVAVGIISHA LAVDLSAPGG RITVDEALLP KPPAADYVYY GKTGYRPSMA AHPDVRRAAE
EFSASDAAAR VYVEEFGMAV EQHERLVAEF MLQPLSRVSH SYGGSRLNKT EKNLCKICLP
PDGGDDRDGG GKSRGGRGGG SKDASRTAMA TGVPHIVHAM RDGRAALALP HLMDVIRVCR
RYDASQKTYL LSCLRLAFAP LVFPGASPPV GADDSPWPTS PIRECAAALR EGFRALNDIR
AEQDPPADER SRELALPLDR AITAARRVAA TAAGLLNAVG ASVVHDGRVG LPAFFLRGVT
ERREDLFSAA RRCPRALYSW ERSMRATTAA LWGHLASRGP IAAPVADLEE LSQALSAVLS
VTSVPDGGDV RYAFAEADEG WRALAVMLGG GAVRTSSGES GDAETDAAYA LLAPGKQSSA
GVNHPRGRPG RATASSPRTP ASRPPHGSAA APPSGRDSPP GALNVPEAAE EELRLAAARD
TTGDLLSDEA GTDDDGDAPV VISYVGPSSP PGVEDPSPDG LAALRPLPEG YVPRPGDVLR
GDPGADENDD DARAPCRVGD ASPPRQLPSS SSFASSSLAS AVPGDPYLPR SVAEPTLCRL
AEHLQSDDGW TRAFANDPVG LAEFARRSTP GRRLGGQRRL DQLLSWTRRH SPRRRYSLIV
LVSEKRPGDF RERAYAAAAL AGRACVPGSA CDPETWRDAE DHPSPSADAQ SPLRSRPSRD
CFPPRIAQPE ASDDDDVGEG GTALLSAGDI GFAGAVESML RRALSRQGQA CAVVDARDDK
DVLSAAAPRF PRGKPGLIYL RVAPPSEACV ANLPSLGPSA SPHRGVGGKH RDKRPCLAEG
TPSAPSCRDA ARATAPLSGD PVAHRLLMHR PAKPLVGEEA CAALLGGKAG RRGQDVPLPF
LTAATLRKVA RVARELDPGW GHGDLGCESA VVFPPAAPPG PELADRHADR RRSTKGPQRP
GGKRPRSSSS SSSASHDRSP SSSSRRRDGR PSSRRRPSRR MSARPPSRPP AAVILRASWR
YAEEVAREML DAAASRFDEA DGEDPLPPAA CGGKPIAPET LVALCEQRGR GPTSLPRAPT
PRSGEALAAP RRSGAKDPRQ GQYCPSARRS EAPHSPSPRD VALRLLERQQ ELNRQLLLEL
RRGSCEISPS PRRRDAEGRR FGCRQDDDDG YDYEGGRESP ERVLGRRQSR RDSVPVRRRS
GAANCGGRWM ISAGRSSSSS SSSSSSSSSS PSSRPSRSAT PSLSPSPSPP RRAPVDRSRS
GRRRERDRPS ANPFRWAPRQ RSRADHSPDG TAPGDAPLNL EDGPGRGRPI WTPSSATTLP
SRSGPEDSVD ETETEDSAPP ARLAPSPLET SRAEDSEDSE YPEYSNPRLG KSPPALKSRE
ARRPSSKQPR RPSSGKNGHT DVSAASAFFL GRPAPGSCGR RPLGARVRGG TER
