ICP4_SUHVF
ID ICP4_SUHVF Reviewed; 1461 AA.
AC P11675;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 2.
DT 02-JUN-2021, entry version 77.
DE RecName: Full=Major viral transcription factor ICP4 homolog;
GN Name=IE;
OS Suid herpesvirus 1 (strain Indiana-Funkhauser / Becker) (SuHV-1)
OS (Pseudorabies virus (strain Indiana-Funkhauser / Becker)).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=31523;
OH NCBI_TaxID=9823; Sus scrofa (Pig).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2546124; DOI=10.1093/nar/17.12.4637;
RA Cheung A.K.;
RT "DNA nucleotide sequence analysis of the immediate-early gene of
RT pseudorabies virus.";
RL Nucleic Acids Res. 17:4637-4646(1989).
RN [2]
RP SEQUENCE REVISION.
RA Cheung A.K.;
RL Submitted (NOV-1989) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This IE protein is a multifunctional protein capable of
CC migrating to the nucleus, binding to DNA, trans-activating other viral
CC genes, and autoregulating its own synthesis.
CC -!- SUBCELLULAR LOCATION: Host nucleus.
CC -!- PTM: A long stretch of serine residues may be a major site of
CC phosphorylation.
CC -!- SIMILARITY: Belongs to the herpesviridae ICP4 family. {ECO:0000305}.
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DR EMBL; X15120; CAA33214.1; -; Genomic_DNA.
DR PIR; S04713; EDBEIF.
DR SMR; P11675; -.
DR PRIDE; P11675; -.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0039695; P:DNA-templated viral transcription; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR005205; Herpes_ICP4_C.
DR InterPro; IPR005206; Herpes_ICP4_N.
DR Pfam; PF03585; Herpes_ICP4_C; 2.
DR Pfam; PF03584; Herpes_ICP4_N; 1.
PE 3: Inferred from homology;
KW DNA-binding; Early protein; Host nucleus; Phosphoprotein; Transcription;
KW Transcription regulation.
FT CHAIN 1..1461
FT /note="Major viral transcription factor ICP4 homolog"
FT /id="PRO_0000115821"
FT REGION 25..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1395..1461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..225
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..282
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..435
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..498
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 815..833
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..882
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..945
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1461 AA; 149834 MW; 7F31E7ABE403B208 CRC64;
MADDLFDFIE TEGNFSQLLA AAAAAAEEEG IASGPDGGSQ GSRRRGSSGE DLLFGPGGLF
SDDAAEAEAA VLAAAAGATR PPRPPSAQQQ RHARRGSGEI VVLDDEDEEE DEPGSPAAGS
PGRALHQGSE HGHLVLGPRS RAGSGPRPPT PAALAAAEAG APGGPGRSSP SAASPASSSS
GSSGSSGSPG PSAAPRRWSP ARGDPVGEPG PAARPRTPAP PAQPAAVAAA PARRGPASPA
SPAAGPVSAP GGGGAPSGGG DRGRHHHQHR EPLLDEPAAA RRLDPRPLGA RSPVSSNPNS
SSSSTTTVAV EPVARGPEKD EDGLGLAGDG GAPLQRQPRR RRAGEGALRR GRGFSSSSSG
GSDSDLSPAR SPSAPRAPAA AAAAARRSAS SSSSSSSSSS SSSSSEGEED EGVRPGAPLA
RAGPPPSPPA PAAAPRPSAS SASATSSSAA ASPAPAPEPA RPPRRKRRST NNHLSLMADG
PPPTDGPLLT PLGEPWPGSD PPADGRVRYG GAGDSREGLW DEDDVRQAAA RYRAAAGPVP
VFIPEMGDSR KQHEALVRLI YSGAAGEAMS WLQNPRMQAP DQRFNQFCQR RVHAPHGHGS
FITGSVTPPL PHIGDAMAAQ DPLWALPHAV SAVAMSRRYD RTQKTFILQS LRRAYADMAY
PGRAADPRAG EATVEALCAR VRAAFAAAQP GRVPRELADA CVLACRGVLE RLLPCPLRLP
APARAPAALG PACLEEVTAA LLALRDAIPG AGPAERQQAA DSVALVARTV APLVRYSVDG
ARAREAAWTY AAALFAPANV AGARLAEAAA RPGPAEPAPG LPPLWPEQPG LVVPAPAPAA
AGAPSGLPGS GPSSPASTKS GSSTKSSSGT KSGLSGSSGY ASSPAAGPDP APERRKKKRR
APGARRPGDG EEDEGLSGSA LRGDGHGHRD DEEDRGPRRK RRSLGLGPAP DPAPALVSSS
SSSSSSEDDR LRRPLGPMPE HPAPDGGFRR VPAGETHTPR PSAAALAAYC PPEVARALVD
QEVFPELWRP ALTFDPAALA HIAARRGAAG APLRRRAAWM RQIADPEDVR VVVLYDPLPH
EELCAEPAEG APRPAWDPRR GGLSALLAAF AHRLCTPDSH AWAGNWTGRP DIGRLNAQGV
LLLSARDLGF AGAVEYLCSR LGAARRRLIV LDTIEDWPAD GPAVGDYHVY VRARLDPAAQ
CAVRWPECRE LRAAVLDSSS IVGPACFARV EASFARLHPG AEPLRLCRQD NVRYTVSTRA
GPRTPVPLPP RAYRERVLPT VDGCKDMARQ RSALGLGDPD FDAGAAFGHR AANRWGLGAP
LRPVFVSCGR RGLAELRGPE GLPAELRAFC AAALLEPDAE AAPLVLAPGA LAAAGAPPAV
RWDFAPFETS VRAAAGGAVE THRPSGARGP GEDGEDSAAV EIVGFRGGDG RPRGPLGPIK
VEAISDDEEA EDAGNPYLLL R
