ID   ICP4_SUHVK              Reviewed;        1446 AA.
AC   P33479;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   02-JUN-2021, entry version 71.
DE   RecName: Full=Major viral transcription factor ICP4 homolog;
GN   Name=IE;
OS   Suid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain
OS   Kaplan)).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=33703;
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2171211; DOI=10.1016/0042-6822(90)90304-a;
RA   Vlcek C., Kozmik Z., Paces V., Schirm S., Schwyzer M.;
RT   "Pseudorabies virus immediate-early gene overlaps with an oppositely
RT   oriented open reading frame: characterization of their promoter and
RT   enhancer regions.";
RL   Virology 179:365-377(1990).
CC   -!- FUNCTION: This IE protein is a multifunctional protein capable of
CC       migrating to the nucleus, binding to DNA, trans-activating other viral
CC       genes, and autoregulating its own synthesis.
CC   -!- SUBCELLULAR LOCATION: Host nucleus.
CC   -!- PTM: A long stretch of serine residues may be a major site of
CC       phosphorylation.
CC   -!- SIMILARITY: Belongs to the herpesviridae ICP4 family. {ECO:0000305}.
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DR   EMBL; M34651; AAA47470.1; -; Genomic_DNA.
DR   PIR; A45344; A45344.
DR   RefSeq; YP_068382.1; NC_006151.1.
DR   RefSeq; YP_068393.1; NC_006151.1.
DR   SMR; P33479; -.
DR   GeneID; 2952493; -.
DR   GeneID; 2952540; -.
DR   KEGG; vg:2952493; -.
DR   KEGG; vg:2952540; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039695; P:DNA-templated viral transcription; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR005205; Herpes_ICP4_C.
DR   InterPro; IPR005206; Herpes_ICP4_N.
DR   Pfam; PF03585; Herpes_ICP4_C; 2.
DR   Pfam; PF03584; Herpes_ICP4_N; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Early protein; Host nucleus; Phosphoprotein; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1446
FT                   /note="Major viral transcription factor ICP4 homolog"
FT                   /id="PRO_0000115822"
FT   REGION          25..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          73..493
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          801..987
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1385..1446
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..217
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        252..274
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        284..303
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        344..361
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        375..398
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        411..427
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        473..487
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        804..822
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        839..871
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        893..934
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1446 AA;  148642 MW;  81F43A3DE3DDA068 CRC64;
     MADDLFDFIE TEGNFSQLLA AAAAAEEEGI ASGPDGGSQG SRRRGSSGED LLFGPGGLFS
     DDAAEAEAAV LAAAAGATRP PRPPSAQQQQ QPRRGSGEIV VLDDEDEEED EPGSPAAGSP
     GRALHQGSEH GHLVLGPRSR AGSGPRPPTP AALAAAEAGA PGGPGRSSPS AASPASSSGS
     PGPSAAPRRW SPARGDPVGE PGPAARPRTP APPAQPAAVA AAPARRGPAS PASPAAGPVS
     APGGGGAPSA GGDRGRHHHQ HREPLLDEPA AARRLDPRPL GARSPVSSNP NSNSNSTTTV
     AVETVARGPE KDEDGLGLAG DGGAPPQRQP RRRRAGEGAL RRGRGFSSSS SSGSDSDLSP
     ARSPSAPRAP AAAARRSASS SSSSSSSSSS SSSSSSSEGE EDEGVRPGAP LARAGPPPSP
     PAPAAAPRPS ASSASSSAAA SPAPAPEPAR PPRRKRRSTN NHLSLMADGP PPTDGPLLTP
     LGEPWPGSDP PADGRVRYGG AGDSREGLWD EDDVRQAAAR YRAAAGPVPV FIPEMGDSRK
     QHEALVRLIY SGAAGEAMSW LQNPRMQAPD QRFNQFCQRR VHAPHGHGSF ITGSVTPPLP
     HIGDAMAAQD PLWALPHAVS AVAMSRRYDR TQKTFILQSL RRAYADMAYP GRAADPRAGE
     ATVEALCARV RAAFAAAQPG RVPRELADAC VLACRGVLER LLPCPLRLPA PARAPAALGP
     ACLEEVTAAL LALRDAIPGA GPAERRQAAD SVALVARTVA PLVRYSVDGA RAREAAWTYA
     AALFAPANVA AARLAEAAAR PGPAEPAPGL PPLWPEQPGL VVPAPAPAAA GAPSGLPGSG
     PSSPASTKSS SSTKSSSSTK SGLSGSSGYA SSPAAGPDPA PERRKKKRRA PGARRPGDGE
     EDEGLSGAAL RGDGHGHRDD EEDRGPRRKR RSLGLGPAPD PAPALLSSSS SSSEDDRLRR
     PLGPMPEHPA PDGGFRRVPA GETHTPRPSE AALAAYCPPE VARALVDQEV FPELWRPALT
     FDPAALAHIA ARRGAPLRRR AAWMRQIADP EDVRVVVLYD PLPHEELCAE PAEGAPRPAW
     DPRRGGLSAL LAAFAHRLCT PDSHAWAGNW TGRPDIGRLN AQGVLLLSAR DLGFAGAVEY
     LCSRLGAARR RLIVLDTIED WPADGPAVGD YHVYVRVRLD PAAQCAVRWP GCRELRAAVL
     DSSSIVGPAC FARVEASFAR LHPGAEPLRL CRQDNVRYTV STRAGPRTPV PLPPRAYRQR
     VLPTVDGCKD MARQRSALGL GDPDFDAGAA FGHRAANRWG LGAPLRPVFV SCGRRGLAEL
     RGPEGLPAEL RAFCAAALLE PDAEAAPLVL TPGAVAAAGA PPAVLWDFAP FETSVRAAAG
     GAVETHRPAG ASGAGAGPGE DGDSVEIVGV RGGDGRPRGP LGPIKVEAIS DDEEAEDAGN
     PYLLLR