ICP4_VZVO
ID ICP4_VZVO Reviewed; 1310 AA.
AC Q8AZM1; Q4JQQ4; Q4JQR3; Q4JQX5; Q8AZM2; Q98WV6; Q9J3N0;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 02-JUN-2021, entry version 54.
DE RecName: Full=Major viral transcription factor ICP4 homolog;
DE AltName: Full=Immediate-early protein 62;
DE Short=IE62;
GN ORFNames=ORF62;
GN and
GN ORFNames=ORF71;
OS Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX NCBI_TaxID=341980;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oka varicella vaccine Biken (V-Oka-Biken);
RX PubMed=10720545; DOI=10.1086/315335;
RA Argaw T., Cohen J.I., Klutch M., Lekstrom K., Yoshikawa T., Asano Y.,
RA Krause P.R.;
RT "Nucleotide sequences that distinguish Oka vaccine from parental Oka and
RT other varicella-zoster virus isolates.";
RL J. Infect. Dis. 181:1153-1157(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate Human/Japan/P-Oka/1970;
RX PubMed=11162813; DOI=10.1006/viro.2000.0775;
RA Faga B., Maury W., Bruckner D.A., Grose C.;
RT "Identification and mapping of single nucleotide polymorphisms in the
RT varicella-zoster virus genome.";
RL Virology 280:1-6(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate Human/Japan/P-Oka/1970, and
RC Oka varicella vaccine Biken (V-Oka-Biken);
RX PubMed=12388706; DOI=10.1128/jvi.76.22.11447-11459.2002;
RA Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.;
RT "Comparison of the complete DNA sequences of the Oka varicella vaccine and
RT its parental virus.";
RL J. Virol. 76:11447-11459(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oka varicella vaccine VarilRix (V-Oka-GSK), and
RC Oka varicella vaccine Varivax (V-Oka-Merk);
RX PubMed=18787000; DOI=10.1128/jvi.00777-08;
RA Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M.,
RA Vassilev V.;
RT "Complete DNA sequences of two oka strain varicella-zoster virus genomes.";
RL J. Virol. 82:11023-11044(2008).
CC -!- FUNCTION: Transcriptional transactivator. May interact with and recruit
CC specific components of the general transcription machinery to viral
CC promoters and stabilize their formation for transcription initiation.
CC Negatively regulates its own transcription. This immediate early (EI)
CC protein may be necessary in virion for viral pathogenesis (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with IE4 and IE63. Interacts with human USF1 and SP1
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}. Host cytoplasm
CC {ECO:0000250}. Virion tegument {ECO:0000250}. Note=Localizes to the
CC cytoplasm when phosphorylated. {ECO:0000250}.
CC -!- PTM: Phosphorylated by ORF66 protein kinase on Ser-686 and Ser-722.
CC Also phosphorylated by ORF47 protein kinase and by human CSNK2A1/CKII
CC (By similarity). {ECO:0000250}.
CC -!- MISCELLANEOUS: Encoded both by ORF62 and ORF71 within the inverted
CC repeat sequences bounding the Us region of the VZV genome.
CC -!- SIMILARITY: Belongs to the herpesviridae ICP4 family. {ECO:0000305}.
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DR EMBL; AF206304; AAF61663.1; -; Genomic_DNA.
DR EMBL; AY016449; AAK19942.1; -; Genomic_DNA.
DR EMBL; AB097932; BAC44881.1; -; Genomic_DNA.
DR EMBL; AB097933; BAC44882.1; -; Genomic_DNA.
DR EMBL; DQ008354; AAY57671.1; -; Genomic_DNA.
DR EMBL; DQ008354; AAY57680.1; -; Genomic_DNA.
DR EMBL; DQ008355; AAY57742.1; -; Genomic_DNA.
DR EMBL; DQ008355; AAY57751.1; -; Genomic_DNA.
DR SMR; Q8AZM1; -.
DR IntAct; Q8AZM1; 23.
DR MINT; Q8AZM1; -.
DR PRIDE; Q8AZM1; -.
DR Proteomes; UP000002603; Genome.
DR Proteomes; UP000008504; Genome.
DR Proteomes; UP000008505; Genome.
DR Proteomes; UP000008506; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0039695; P:DNA-templated viral transcription; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR005205; Herpes_ICP4_C.
DR InterPro; IPR005206; Herpes_ICP4_N.
DR Pfam; PF03585; Herpes_ICP4_C; 1.
DR Pfam; PF03584; Herpes_ICP4_N; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Early protein; Host cytoplasm; Host nucleus;
KW Phosphoprotein; Transcription; Transcription regulation; Virion;
KW Virion tegument.
FT CHAIN 1..1310
FT /note="Major viral transcription factor ICP4 homolog"
FT /id="PRO_0000385461"
FT REGION 117..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1195..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1282..1310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 677..685
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 189..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..437
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..696
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1210..1231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1232..1247
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 686
FT /note="Phosphoserine; by VZV ORF66"
FT /evidence="ECO:0000250"
FT MOD_RES 722
FT /note="Phosphoserine; by VZV ORF66"
FT /evidence="ECO:0000250"
FT VARIANT 628
FT /note="S -> G (in strain: Oka varicella vaccine Biken (V-
FT Oka-Biken), Oka varicella vaccine VarilRix (V-Oka-GSK) and
FT Oka varicella vaccine Varivax (V-Oka-Merk))"
FT VARIANT 958
FT /note="R -> G (in strain: Oka varicella vaccine Biken (V-
FT Oka-Biken), Oka varicella vaccine VarilRix (V-Oka-GSK) and
FT Oka varicella vaccine Varivax (V-Oka-Merk))"
FT VARIANT 1197
FT /note="V -> A (in strain: Oka varicella vaccine Biken (V-
FT Oka-Biken), Oka varicella vaccine VarilRix (V-Oka-GSK) and
FT Oka varicella vaccine Varivax (V-Oka-Merk))"
FT VARIANT 1260
FT /note="I -> V (in strain: Oka varicella vaccine Biken (V-
FT Oka-Biken), Oka varicella vaccine VarilRix (V-Oka-GSK) and
FT Oka varicella vaccine Varivax (V-Oka-Merk))"
FT VARIANT 1275
FT /note="L -> S (in strain: Oka varicella vaccine Biken (V-
FT Oka-Biken))"
SQ SEQUENCE 1310 AA; 139996 MW; 2A0EF6D19515CAC0 CRC64;
MDTPPMQRST PQRAGSPDTL ELMDLLDAAA AAAEHRARVV TSSQPDDLLF GENGVMVGRE
HEIVSIPSVS GLQPEPRTED VGEELTQDDY VCEDGQDLMG SPVIPLAEVF HTRFSEAGAR
EPTGADRSLE TVSLGTKLAR SPKPPMNDGE TGRGTTPPFP QAFSPVSPAS PVGDAAGNDQ
REDQRSIPRQ TTRGNSPGLP SVVHRDRQTQ SISGKKPGDE QAGHAHASGD GVVLQKTQRP
AQGKSPKKKT LKVKVPLPAR KPGGPVPGPV EQLYHVLSDS VPAKGAKADL PFETDDTRPR
KHDARGITPR VPGRSSGGKP RAFLALPGRS HAPDPIEDDS PVEKKPKSRE FVSSSSSSSS
WGSSSEDEDD EPRRVSVGSE TTGSRSGREH APSPSNSDDS DSNDGGSTKQ NIQPGYRSIS
GPDPRIRKTK RLAGEPGRQR QKSFSLPRSR TPIIPPVSGP LMMPDGSPWP GSAPLPSNRV
RFGPSGETRE GHWEDEAVRA ARARYEASTE PVPLYVPELG DPARQYRALI NLIYCPDRDP
IAWLQNPKLT GVNSALNQFY QKLLPPGRAG TAVTGSVASP VPHVGEAMAT GEALWALPHA
AAAVAMSRRY DRAQKHFILQ SLRRAFASMA YPEATGSSPA ARISRGHPSP TTPATQTPDP
QPSAAARSLS VCPPDDRLRT PRKRKSQPVE SRSLLDKIRE TPVADARVAD DHVVSKAKRR
VSEPVTITSG PVVDPPAVIT MPLDGPAPNG GFRRIPRGAL HTPVPSDQAR KAYCTPETIA
RLVDDPLFPT AWRPALSFDP GALAEIAARR PGGGDRRFGP PSGVEALRRR CAWMRQIPDP
EDVRLLIIYD PLPGEDINGP LESTLATDPG PSWSPSRGGL SVVLAALSNR LCLPSTHAWA
GNWTGPPDVS ALNARGVLLL STRDLAFAGA VEYLGSRLAS ARRRLLVLDA VALERWPRDG
PALSQYHVYV RAPARPDAQA VVRWPDSAVT EGLARAVFAS SRTFGPASFA RIETAFANLY
PGEQPLCLCR GGNVAYTVCT RAGPKTRVPL SPREYRQYVL PGFDGCKDLA RQSRGLGLGA
ADFVDEAAHS HRAANRWGLG AALRPVFLPE GRRPGAAGPE AGDVPTWARV FCRHALLEPD
PAAEPLVLPP VAGRSVALYA SADEARNALP PIPRVMWPPG FGAAETVLEG SDGTRFVFGH
HGGSERPAET QAGRQRRTAD DREHALEPDD WEVGCEDAWD SEEGGGDDGD APGSSFGVSI
VSVAPGVLRD RRVGLRPAVK VELLSSSSSS EDEDDVWGGR GGRSPPQSRG
