ICR2_ARATH
ID ICR2_ARATH Reviewed; 583 AA.
AC Q9ZQC5; Q0WWY7;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Interactor of constitutive active ROPs 2, chloroplastic;
DE AltName: Full=ROP-interactive partner 2;
DE Flags: Precursor;
GN Name=ICR2; Synonyms=RIP2; OrderedLocusNames=At2g37080; ORFNames=T2N18.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-382.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION, AND INTERACTION WITH ARAC8; ICR1 AND SEC3A.
RX PubMed=17493810; DOI=10.1016/j.cub.2007.04.038;
RA Lavy M., Bloch D., Hazak O., Gutman I., Poraty L., Sorek N., Sternberg H.,
RA Yalovsky S.;
RT "A Novel ROP/RAC effector links cell polarity, root-meristem maintenance,
RT and vesicle trafficking.";
RL Curr. Biol. 17:947-952(2007).
RN [6]
RP INTERACTION WITH ARAC11, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19825600; DOI=10.1093/mp/ssn051;
RA Li S., Gu Y., Yan A., Lord E., Yang Z.B.;
RT "RIP1 (ROP Interactive Partner 1)/ICR1 marks pollen germination sites and
RT may act in the ROP1 pathway in the control of polarized pollen growth.";
RL Mol. Plant 1:1021-1035(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP ANALYSIS].
RX PubMed=18431481; DOI=10.1371/journal.pone.0001994;
RA Zybailov B., Rutschow H., Friso G., Rudella A., Emanuelsson O., Sun Q.,
RA van Wijk K.J.;
RT "Sorting signals, N-terminal modifications and abundance of the chloroplast
RT proteome.";
RL PLoS ONE 3:E1994-E1994(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-540, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
RN [9]
RP INTERACTION WITH KIN13A.
RX PubMed=20832900; DOI=10.1016/j.ejcb.2010.08.003;
RA Mucha E., Hoefle C., Huckelhoven R., Berken A.;
RT "RIP3 and AtKinesin-13A - a novel interaction linking Rho proteins of
RT plants to microtubules.";
RL Eur. J. Cell Biol. 89:906-916(2010).
CC -!- FUNCTION: Acts as a scaffold, mediating interaction of ROPs with
CC different proteins. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ARAC8, ARAC11 and KIN13A in vitro, but not with
CC ICR1 or SEC3A. {ECO:0000269|PubMed:17493810,
CC ECO:0000269|PubMed:19825600, ECO:0000269|PubMed:20832900}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast
CC {ECO:0000269|PubMed:18431481}.
CC -!- SIMILARITY: Belongs to the ICR family. {ECO:0000305}.
CC -!- CAUTION: Due to the probable chloroplastic localization, the
CC interactions with ROPs are questionable. {ECO:0000305}.
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DR EMBL; AC006260; AAD18151.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09349.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM61939.1; -; Genomic_DNA.
DR EMBL; BT020383; AAV91329.1; -; mRNA.
DR EMBL; BT020462; AAW30040.1; -; mRNA.
DR EMBL; AK226196; BAE98361.1; -; mRNA.
DR PIR; C84788; C84788.
DR RefSeq; NP_001324128.1; NM_001336624.1.
DR RefSeq; NP_181245.1; NM_129264.4.
DR AlphaFoldDB; Q9ZQC5; -.
DR SMR; Q9ZQC5; -.
DR BioGRID; 3628; 1.
DR STRING; 3702.AT2G37080.1; -.
DR iPTMnet; Q9ZQC5; -.
DR PaxDb; Q9ZQC5; -.
DR PRIDE; Q9ZQC5; -.
DR ProteomicsDB; 228768; -.
DR EnsemblPlants; AT2G37080.1; AT2G37080.1; AT2G37080.
DR EnsemblPlants; AT2G37080.2; AT2G37080.2; AT2G37080.
DR GeneID; 818284; -.
DR Gramene; AT2G37080.1; AT2G37080.1; AT2G37080.
DR Gramene; AT2G37080.2; AT2G37080.2; AT2G37080.
DR KEGG; ath:AT2G37080; -.
DR Araport; AT2G37080; -.
DR TAIR; locus:2061758; AT2G37080.
DR eggNOG; ENOG502QT2U; Eukaryota.
DR HOGENOM; CLU_022222_0_0_1; -.
DR InParanoid; Q9ZQC5; -.
DR OMA; QIMAMSA; -.
DR OrthoDB; 750263at2759; -.
DR PhylomeDB; Q9ZQC5; -.
DR PRO; PR:Q9ZQC5; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZQC5; baseline and differential.
DR Genevisible; Q9ZQC5; AT.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR InterPro; IPR029688; ICR.
DR PANTHER; PTHR34224; PTHR34224; 1.
PE 1: Evidence at protein level;
KW Chloroplast; Coiled coil; Phosphoprotein; Plastid; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..55
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 56..583
FT /note="Interactor of constitutive active ROPs 2,
FT chloroplastic"
FT /id="PRO_0000356302"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 74..207
FT /evidence="ECO:0000255"
FT COILED 238..516
FT /evidence="ECO:0000255"
FT COMPBIAS 15..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 540
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19376835"
FT CONFLICT 68..69
FT /note="Missing (in Ref. 4; BAE98361)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 583 AA; 65858 MW; 867888888C4038FE CRC64;
MQTPKPRPGS LEVPQKKSPA STPKTARKLK TSESDPVSSP NTKIRTPKTQ SPKVVADRRS
PRTPVNEIQK KRTGKTPELA SQISQLQEEL KKAKEQLSAS EALKKEAQDQ AEETKQQLME
INASEDSRID ELRKLSQERD KAWQSELEAM QRQHAMDSAA LSSTMNEVQK LKAQLSESEN
VENLRMELNE TLSLVEKLRG ELFDAKEGEA QAHEIVSGTE KQLEIANLTL EMLRSDGMKM
SEACNSLTTE LEQSKSEVRS LEQLVRQLEE EDEARGNANG DSSSVEELKE EINVARQEIS
QLKSAVEVTE RRYHEEYIQS TLQIRTAYEQ VDEVKSGYAQ REAELGEELK KTKAERDSLH
ERLMDKEAKL RILVDENEIL NSKIKEKEEV YLNLENSLNQ NEPEDTGELK KLESDVMELR
ANLMDKEMEL QSVMSQYESL RSEMETMQSE KNKAIDEALA KLGSLTEEAD KSGKRAENAT
EQLGAAQVTN TELEAELRRL KVQCDQWRKA AEAAATMLSG GNNNNNSNGK YVERTGSLES
PLRRRNVNMS PYMGETDDEL SSPKKKNGSM LKKIGVLLKK SQK
