ID   ICS3_YEAST              Reviewed;         131 AA.
AC   P47034; D6VWA7;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Increased copper sensitivity protein 3;
GN   Name=ICS3; OrderedLocusNames=YJL077C; ORFNames=J1033;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA   Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA   Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA   Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA   Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA   Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA   Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA   Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA   Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA   To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA   von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL   EMBO J. 15:2031-2049(1996).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=10628851; DOI=10.1007/pl00013817;
RA   Entian K.-D., Schuster T., Hegemann J.H., Becher D., Feldmann H.,
RA   Gueldener U., Goetz R., Hansen M., Hollenberg C.P., Jansen G., Kramer W.,
RA   Klein S., Koetter P., Kricke J., Launhardt H., Mannhaupt G., Maierl A.,
RA   Meyer P., Mewes W., Munder T., Niedenthal R.K., Ramezani Rad M.,
RA   Roehmer A., Roemer A., Rose M., Schaefer B., Siegler M.-L., Vetter J.,
RA   Wilhelm N., Wolf K., Zimmermann F.K., Zollner A., Hinnen A.;
RT   "Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by
RT   a systematic approach.";
RL   Mol. Gen. Genet. 262:683-702(1999).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Increases sensitivity to copper.
CC       {ECO:0000269|PubMed:10628851}.
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DR   EMBL; Z49352; CAA89369.1; -; Genomic_DNA.
DR   EMBL; AY692701; AAT92720.1; -; Genomic_DNA.
DR   EMBL; BK006943; DAA08723.1; -; Genomic_DNA.
DR   PIR; S56853; S56853.
DR   RefSeq; NP_012458.1; NM_001181510.1.
DR   AlphaFoldDB; P47034; -.
DR   BioGRID; 33679; 23.
DR   STRING; 4932.YJL077C; -.
DR   PaxDb; P47034; -.
DR   PRIDE; P47034; -.
DR   EnsemblFungi; YJL077C_mRNA; YJL077C; YJL077C.
DR   GeneID; 853368; -.
DR   KEGG; sce:YJL077C; -.
DR   SGD; S000003613; ICS3.
DR   VEuPathDB; FungiDB:YJL077C; -.
DR   HOGENOM; CLU_1928785_0_0_1; -.
DR   BioCyc; YEAST:G3O-31534-MON; -.
DR   PRO; PR:P47034; -.
DR   Proteomes; UP000002311; Chromosome X.
DR   RNAct; P47034; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055070; P:copper ion homeostasis; IMP:SGD.
PE   4: Predicted;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..131
FT                   /note="Increased copper sensitivity protein 3"
FT                   /id="PRO_0000203052"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   131 AA;  14828 MW;  1A5AB2ABC6C8BB97 CRC64;
     MHISLPTRNK SYFRIRTRTY QIGLYHSDSS PIRDISVLHL LIATLCTIFF PIFFSLSKVQ
     VVQWQGTTIS KNCIALTMSF PLNAIPGMYL IIAFPRLQTV IPLQRNTPVR ITKSVIVKGA
     VSVPRISSPM H