ID   ICSA_ASPFU              Reviewed;         602 AA.
AC   Q4W9F7;
DT   10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Isocyanide synthase A {ECO:0000303|PubMed:29844112};
DE            Short=ICS A {ECO:0000303|PubMed:29844112};
DE            EC=1.-.-.- {ECO:0000305|PubMed:29844112};
GN   Name=icsA {ECO:0000303|PubMed:29844112}; ORFNames=AFUA_4G01370;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
RN   [2]
RP   FUNCTION.
RX   PubMed=29844112; DOI=10.1128/mbio.00785-18;
RA   Lim F.Y., Won T.H., Raffa N., Baccile J.A., Wisecaver J., Rokas A.,
RA   Schroeder F.C., Keller N.P.;
RT   "Fungal isocyanide synthases and xanthocillin biosynthesis in Aspergillus
RT   fumigatus.";
RL   MBio 9:0-0(2018).
CC   -!- FUNCTION: Isocyanide synthase involved in the biosynthesis of
CC       isocyanides (or isonitriles), a class of microbial secondary
CC       metabolites. The presence of an isonitrile moiety within a compound
CC       imparts unique biological (cytotoxic, antibacterial, and antiprotozoal)
CC       and chemical (transition metal coordination) properties and enables
CC       synthetic and biochemical applications. {ECO:0000269|PubMed:29844112}.
CC   -!- SIMILARITY: Belongs to the isocyanide synthase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAHF01000017; EAL84283.1; -; Genomic_DNA.
DR   RefSeq; XP_746321.1; XM_741228.1.
DR   AlphaFoldDB; Q4W9F7; -.
DR   SMR; Q4W9F7; -.
DR   STRING; 746128.CADAFUBP00009894; -.
DR   EnsemblFungi; EAL84283; EAL84283; AFUA_4G01370.
DR   GeneID; 3503829; -.
DR   KEGG; afm:AFUA_4G01370; -.
DR   VEuPathDB; FungiDB:Afu4g01370; -.
DR   eggNOG; ENOG502RNZ1; Eukaryota.
DR   HOGENOM; CLU_015940_0_0_1; -.
DR   InParanoid; Q4W9F7; -.
DR   OMA; HHTRTAF; -.
DR   OrthoDB; 934123at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.130.10; -; 1.
DR   InterPro; IPR007817; Isocyanide_synthase_DIT1.
DR   InterPro; IPR042098; TauD-like_sf.
DR   InterPro; IPR003819; TauD/TfdA-like.
DR   PANTHER; PTHR37285; PTHR37285; 1.
DR   Pfam; PF05141; DIT1_PvcA; 2.
DR   Pfam; PF02668; TauD; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..602
FT                   /note="Isocyanide synthase A"
FT                   /id="PRO_0000445291"
SQ   SEQUENCE   602 AA;  67705 MW;  9FBECC5BFBF8FD40 CRC64;
     MPYAGNLPTP TENKVSQIIS IISAYRHRSA AVPDRFSEFA PALEKQLTET VSKGEPVRFI
     LPSFPFKAPA EGDKRKTLGS LPDKAEEIAL QTLDAFADSI AEIHQPGATV VIVSDASVYG
     DLLKIPDADA FAYHQELKKL AASLGLTHLE FVRPGTLAGI VPEEAKTLEE YSDHVSKTRN
     LLDGTLAQAV DPNEDENMRA TSKHYDTALP QAEDHEAFKA AMLKRGKAYA KLIASSAEST
     IRLSIHESNN VGKITMNLFP PPTSPDFITP WHGAVAVLAD ASVRIVDAST VDRDRFEVIT
     NHEGRPWLLR EKSDLFDWFG MELDFEPLFP CGMQVRPKEG YGPYRFEDVN MKLVRRLALS
     TAPLLLRGFT MQVEKEVFRS KARELGEIQM WPFGDILEVR ENADFNMNNV LTREAMPFHY
     DGVFKTVQDE KTGEWISVPP LFQMFRNRAA SQSKGGLTLF ASSRNLIPLL GPDSIPLEEL
     RKLQWETFTA ANEAFGGHKL QLPFIITHPE SGVDTFRFHE PWPESKCVPG SSEPTLVRVV
     GWPLAESDAL CEKLTRLLYD RRVAYRHQWK AGDFIFNDNA MTHHTRTAFE DGHREHWRVH
     VN