ID   ICTL_PIG                Reviewed;          96 AA.
AC   P15175;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 2.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Cathelin;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE, AND PYROGLUTAMATE FORMATION AT GLN-1.
RC   TISSUE=Leukocyte;
RX   PubMed=2792375; DOI=10.1016/0014-5793(89)81093-2;
RA   Ritonja A., Kopitar M., Jerala R., Turk V.;
RT   "Primary structure of a new cysteine proteinase inhibitor from pig
RT   leucocytes.";
RL   FEBS Lett. 255:211-214(1989).
RN   [2]
RP   REVISION OF FUNCTION, AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Leukocyte;
RX   PubMed=8262248; DOI=10.1016/0014-5793(93)80822-c;
RA   Lenarcic B., Ritonja A., Dolenc I., Stoka V., Berbic S., Pungercar J.,
RA   Strukelj B., Turk V.;
RT   "Pig leukocyte cysteine proteinase inhibitor (PLCPI), a new member of the
RT   stefin family.";
RL   FEBS Lett. 336:289-292(1993).
CC   -!- FUNCTION: Probably a microbicidal peptide.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the cathelicidin family. {ECO:0000305}.
CC   -!- CAUTION: Was originally (PubMed:2792375) thought to be a thiol protease
CC       inhibitor. The inhibitory activity was due to the presence of leukocyte
CC       cysteine proteinase inhibitor and not to cathelin itself.
CC       {ECO:0000305|PubMed:2792375}.
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DR   PIR; S05660; XKPGC.
DR   AlphaFoldDB; P15175; -.
DR   SMR; P15175; -.
DR   TCDB; 1.C.33.1.4; the cathelicidin (cathelicidin) family.
DR   PeptideAtlas; P15175; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0001530; F:lipopolysaccharide binding; IBA:GO_Central.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   InterPro; IPR001894; Cathelicidin-like.
DR   InterPro; IPR018216; Cathelicidin_CS.
DR   InterPro; IPR046350; Cystatin_sf.
DR   PANTHER; PTHR10206; PTHR10206; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00946; CATHELICIDINS_1; 1.
DR   PROSITE; PS00947; CATHELICIDINS_2; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Disulfide bond;
KW   Pyrrolidone carboxylic acid; Reference proteome; Secreted.
FT   CHAIN           1..96
FT                   /note="Cathelin"
FT                   /id="PRO_0000148293"
FT   REGION          31..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:2792375"
FT   DISULFID        55..66
FT                   /evidence="ECO:0000250"
FT   DISULFID        73..90
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   96 AA;  10850 MW;  3596D5EFD501A130 CRC64;
     QLRYREAVLR AVDRLNEQSS EANLYRLLEL DQPPKADEDP GTPKPVSFTV KETVCPRPTR
     QPPELCDFKE KQCVGTVTLN PSIHSLDISC NEIQSV