ID   ICY1_YEAST              Reviewed;         127 AA.
AC   Q04329; D6W020;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Interacting with cytoskeleton protein 1;
GN   Name=ICY1; OrderedLocusNames=YMR195W; ORFNames=YM9646.08;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169872;
RA   Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA   Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA   Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA   Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL   Nature 387:90-93(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   FUNCTION.
RX   PubMed=14504216; DOI=10.1093/genetics/165.1.35;
RA   Dunn C.D., Jensen R.E.;
RT   "Suppression of a defect in mitochondrial protein import identifies
RT   cytosolic proteins required for viability of yeast cells lacking
RT   mitochondrial DNA.";
RL   Genetics 165:35-45(2003).
RN   [5]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [6]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=12673624; DOI=10.1002/yea.970;
RA   Suzuki C., Hori Y., Kashiwagi Y.;
RT   "Screening and characterization of transposon-insertion mutants in a
RT   pseudohyphal strain of Saccharomyces cerevisiae.";
RL   Yeast 20:407-415(2003).
RN   [7]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [8]
RP   INDUCTION.
RX   PubMed=15843968; DOI=10.1007/s00438-005-1139-4;
RA   Kleinschmidt M., Grundmann O., Bluethgen N., Moesch H.-U., Braus G.H.;
RT   "Transcriptional profiling of Saccharomyces cerevisiae cells under
RT   adhesion-inducing conditions.";
RL   Mol. Genet. Genomics 273:382-393(2005).
CC   -!- FUNCTION: Required for viability of cells lacking mtDNA.
CC       {ECO:0000269|PubMed:14504216}.
CC   -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000269|PubMed:14562095};
CC       Peripheral membrane protein {ECO:0000269|PubMed:14562095}.
CC   -!- INDUCTION: Induced by amino acids starvation.
CC       {ECO:0000269|PubMed:15843968}.
CC   -!- DISRUPTION PHENOTYPE: Invasive growth defect with elongated cell
CC       morphology. {ECO:0000269|PubMed:12673624}.
CC   -!- MISCELLANEOUS: Present with 4050 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; Z47815; CAA87817.1; -; Genomic_DNA.
DR   EMBL; AY557963; AAS56289.1; -; Genomic_DNA.
DR   EMBL; BK006946; DAA10094.1; -; Genomic_DNA.
DR   PIR; S50924; S50924.
DR   RefSeq; NP_013922.1; NM_001182702.1.
DR   AlphaFoldDB; Q04329; -.
DR   BioGRID; 35373; 52.
DR   DIP; DIP-4170N; -.
DR   IntAct; Q04329; 1.
DR   MINT; Q04329; -.
DR   STRING; 4932.YMR195W; -.
DR   PaxDb; Q04329; -.
DR   PRIDE; Q04329; -.
DR   EnsemblFungi; YMR195W_mRNA; YMR195W; YMR195W.
DR   GeneID; 855235; -.
DR   KEGG; sce:YMR195W; -.
DR   SGD; S000004808; ICY1.
DR   VEuPathDB; FungiDB:YMR195W; -.
DR   HOGENOM; CLU_149528_0_0_1; -.
DR   InParanoid; Q04329; -.
DR   OMA; DCRMAVA; -.
DR   BioCyc; YEAST:G3O-32882-MON; -.
DR   PRO; PR:Q04329; -.
DR   Proteomes; UP000002311; Chromosome XIII.
DR   RNAct; Q04329; protein.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; HDA:SGD.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Vacuole.
FT   CHAIN           1..127
FT                   /note="Interacting with cytoskeleton protein 1"
FT                   /id="PRO_0000203325"
SQ   SEQUENCE   127 AA;  14337 MW;  AC10827A6CCE7E70 CRC64;
     MSSNYATPLD DEVFPLSFAN YQFTEHVSLG EHYSLNTSED AKYNNLNGPF VVPRDTGKFD
     LNTSSASDET VFSLDNPQEN NYKHQAMNNV QDCRMAVAAK TTQSCDKLTD LYANAAQQNY
     RLWLSSF