ID   ID2B_XENLA              Reviewed;         135 AA.
AC   Q66J78;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=DNA-binding protein inhibitor ID-2-B;
DE   AltName: Full=Inhibitor of DNA binding 2-B;
DE   AltName: Full=Inhibitor of differentiation 2-B;
GN   Name=id2-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAH81029.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula {ECO:0000312|EMBL:AAH81029.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional regulator (lacking a basic DNA binding
CC       domain) which negatively regulates the basic helix-loop-helix (bHLH)
CC       transcription factors by forming heterodimers and inhibiting their DNA
CC       binding and transcriptional activity. Inhibits the activity of both
CC       neurogenic (neurod1/neuroD) and myogenic (myod1/myoD) bHLH factors. May
CC       play a role in the regulation of the circadian clock (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with other HLH proteins.
CC       {ECO:0000250|UniProtKB:Q02363}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000250|UniProtKB:Q02363,
CC       ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR   EMBL; BC081029; AAH81029.1; -; mRNA.
DR   RefSeq; NP_001087639.1; NM_001094170.1.
DR   AlphaFoldDB; Q66J78; -.
DR   SMR; Q66J78; -.
DR   DNASU; 447463; -.
DR   GeneID; 447463; -.
DR   KEGG; xla:447463; -.
DR   CTD; 447463; -.
DR   Xenbase; XB-GENE-17341008; id2.S.
DR   OMA; NITTHLC; -.
DR   OrthoDB; 1624054at2759; -.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 447463; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0032991; C:protein-containing complex; ISS:UniProtKB.
DR   GO; GO:0043425; F:bHLH transcription factor binding; ISS:UniProtKB.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0090398; P:cellular senescence; ISS:UniProtKB.
DR   GO; GO:0048557; P:embryonic digestive tract morphogenesis; ISS:UniProtKB.
DR   GO; GO:0061031; P:endodermal digestive tract morphogenesis; ISS:UniProtKB.
DR   GO; GO:0010629; P:negative regulation of gene expression; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0048663; P:neuron fate commitment; ISS:UniProtKB.
DR   GO; GO:0045777; P:positive regulation of blood pressure; ISS:UniProtKB.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR   GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB.
DR   GO; GO:0010468; P:regulation of gene expression; ISS:UniProtKB.
DR   GO; GO:2000177; P:regulation of neural precursor cell proliferation; ISS:UniProtKB.
DR   GO; GO:0045664; P:regulation of neuron differentiation; ISS:UniProtKB.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR026052; DNA-bd_prot-inh.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   PANTHER; PTHR11723; PTHR11723; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Biological rhythms; Cytoplasm; Developmental protein; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..135
FT                   /note="DNA-binding protein inhibitor ID-2-B"
FT                   /id="PRO_0000390722"
FT   DOMAIN          23..75
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   MOTIF           108..117
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   135 AA;  14990 MW;  1544163C1FC8C724 CRC64;
     MKAFSPVRSV RKSSLTEHSL GIARSKAPVD EPMSLLYNMN DCYSKLKELV PSIPPNKKVS
     KMEILQHVID YILDLQLTLD SHPTLVSLHH HHLSRVGGNT SRTPLTALNT DISILSLQAV
     ELSSEFTDES KSLCP