ID2_XENTR
ID ID2_XENTR Reviewed; 132 AA.
AC Q6PBD7;
DT 19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=DNA-binding protein inhibitor ID-2 {ECO:0000250|UniProtKB:Q02363};
DE AltName: Full=Inhibitor of DNA binding 2 {ECO:0000250|UniProtKB:Q02363};
DE AltName: Full=Inhibitor of differentiation 2;
GN Name=id2 {ECO:0000312|EMBL:AAH59758.1}; ORFNames=TTpA010o03.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:AAY99629.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Qin S., Dors M., Johnson E., Bloom S., Hood L., Rowen L.;
RT "Sequence of Xenopus tropicalis development genes.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:AAY99629.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tadpole {ECO:0000312|EMBL:CAJ83121.1};
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000312|EMBL:AAY99629.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula {ECO:0000312|EMBL:AAH59758.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional regulator (lacking a basic DNA binding
CC domain) which negatively regulates the basic helix-loop-helix (bHLH)
CC transcription factors by forming heterodimers and inhibiting their DNA
CC binding and transcriptional activity. Inhibits the activity of both
CC neurogenic (neurod1/neuroD) and myogenic (myod1/myoD) bHLH factors. May
CC play a role in the regulation of the circadian clock (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer with other HLH proteins.
CC {ECO:0000250|UniProtKB:Q02363}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P41136}. Nucleus
CC {ECO:0000250|UniProtKB:P41136}.
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DR EMBL; AC151469; AAY99629.1; -; Genomic_DNA.
DR EMBL; CR855815; CAJ83121.1; -; mRNA.
DR EMBL; BC059758; AAH59758.1; -; mRNA.
DR RefSeq; NP_988885.1; NM_203554.1.
DR AlphaFoldDB; Q6PBD7; -.
DR SMR; Q6PBD7; -.
DR DNASU; 394480; -.
DR Ensembl; ENSXETT00000100793; ENSXETP00000078956; ENSXETG00000040416.
DR GeneID; 394480; -.
DR KEGG; xtr:394480; -.
DR CTD; 3398; -.
DR Xenbase; XB-GENE-481297; id2.
DR InParanoid; Q6PBD7; -.
DR OrthoDB; 1624054at2759; -.
DR Proteomes; UP000008143; Chromosome 5.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000040416; Expressed in 2-cell stage embryo and 19 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0032991; C:protein-containing complex; ISS:UniProtKB.
DR GO; GO:0043425; F:bHLH transcription factor binding; ISS:UniProtKB.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0090398; P:cellular senescence; ISS:UniProtKB.
DR GO; GO:0032922; P:circadian regulation of gene expression; IBA:GO_Central.
DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; ISS:UniProtKB.
DR GO; GO:0061031; P:endodermal digestive tract morphogenesis; ISS:UniProtKB.
DR GO; GO:0010629; P:negative regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0048663; P:neuron fate commitment; ISS:UniProtKB.
DR GO; GO:0045777; P:positive regulation of blood pressure; ISS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB.
DR GO; GO:0010468; P:regulation of gene expression; ISS:UniProtKB.
DR GO; GO:2000177; P:regulation of neural precursor cell proliferation; ISS:UniProtKB.
DR GO; GO:0045664; P:regulation of neuron differentiation; ISS:UniProtKB.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR026052; DNA-bd_prot-inh.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR11723; PTHR11723; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Biological rhythms; Cytoplasm; Developmental protein; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..132
FT /note="DNA-binding protein inhibitor ID-2"
FT /id="PRO_0000390723"
FT DOMAIN 23..75
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT MOTIF 105..114
FT /note="Nuclear export signal"
FT /evidence="ECO:0000250"
SQ SEQUENCE 132 AA; 14519 MW; 9ADDBB78B370DD9A CRC64;
MKAFSPVRSV RKSSLTEHSL GIARSKTPVD DPMSLLYNMN DCYSKLKELV PSIPQNKKVS
KMEILQHVID YILDLQLALD SHPSIVSLHH ARVGGSTSRT PLTALNTDIS ILSLQAAELS
AEFTDESKSL CP
