ID3_BOVIN
ID ID3_BOVIN Reviewed; 119 AA.
AC Q5E981; Q3T121;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=DNA-binding protein inhibitor ID-3;
DE AltName: Full=Inhibitor of DNA binding 3;
DE AltName: Full=Inhibitor of differentiation 3;
GN Name=ID3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional regulator (lacking a basic DNA binding
CC domain) which negatively regulates the basic helix-loop-helix (bHLH)
CC transcription factors by forming heterodimers and inhibiting their DNA
CC binding and transcriptional activity. Implicated in regulating a
CC variety of cellular processes, including cellular growth, senescence,
CC differentiation, apoptosis, angiogenesis, and neoplastic
CC transformation. Involved in myogenesis by inhibiting skeletal muscle
CC and cardiac myocyte differentiation and promoting muscle precursor
CC cells proliferation. Inhibits the binding of E2A-containing protein
CC complexes to muscle creatine kinase E-box enhancer. Regulates the
CC circadian clock by repressing the transcriptional activator activity of
CC the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer, and heterodimer with other HLH proteins. Interacts
CC with COPS5 and COPS7A. Interacts with IFI204. Interacts with GATA4 and
CC NKX2-5. Interacts with ANKRD2; both proteins cooperate in myoblast
CC differentiation. Interacts with CLOCK and ARNTL/BMAL1 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR EMBL; BT021039; AAX09056.1; -; mRNA.
DR EMBL; BC102157; AAI02158.1; -; mRNA.
DR RefSeq; NP_001014950.1; NM_001014950.1.
DR AlphaFoldDB; Q5E981; -.
DR SMR; Q5E981; -.
DR STRING; 9913.ENSBTAP00000019148; -.
DR PaxDb; Q5E981; -.
DR PRIDE; Q5E981; -.
DR Ensembl; ENSBTAT00000019148; ENSBTAP00000019148; ENSBTAG00000030425.
DR GeneID; 538690; -.
DR KEGG; bta:538690; -.
DR CTD; 3399; -.
DR VEuPathDB; HostDB:ENSBTAG00000030425; -.
DR VGNC; VGNC:30032; ID3.
DR eggNOG; ENOG502S53I; Eukaryota.
DR GeneTree; ENSGT00940000160504; -.
DR HOGENOM; CLU_116790_1_0_1; -.
DR InParanoid; Q5E981; -.
DR OMA; PARGCYE; -.
DR OrthoDB; 1624054at2759; -.
DR TreeFam; TF326217; -.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000030425; Expressed in oocyte and 111 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043425; F:bHLH transcription factor binding; IEA:Ensembl.
DR GO; GO:1901707; F:leptomycin B binding; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0140416; F:transcription regulator inhibitor activity; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0072750; P:cellular response to leptomycin B; IEA:Ensembl.
DR GO; GO:0007417; P:central nervous system development; IEA:Ensembl.
DR GO; GO:0032922; P:circadian regulation of gene expression; IBA:GO_Central.
DR GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0001656; P:metanephros development; IEA:Ensembl.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0030903; P:notochord development; IEA:Ensembl.
DR GO; GO:0042476; P:odontogenesis; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR026052; DNA-bd_prot-inh.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR11723; PTHR11723; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW Biological rhythms; Myogenesis; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..119
FT /note="DNA-binding protein inhibitor ID-3"
FT /id="PRO_0000127245"
FT DOMAIN 28..80
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
SQ SEQUENCE 119 AA; 12999 MW; 6A979E17E0DC4BBD CRC64;
MKALSPVRGC YEAVCCLSER SLAIARGRGK SPAAEEPLSL LDDMNHCYSR LRELVPGVPR
GTQLSQVEIL QRVIDYILDL QVVLAEPAPG PPDGPHLPIQ TAELAPELVI SNDQRSFCH
