APC13_ARATH
ID APC13_ARATH Reviewed; 63 AA.
AC Q8L981;
DT 08-JUN-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Anaphase-promoting complex subunit 13 {ECO:0000303|PubMed:17627280};
DE AltName: Full=Protein BONSAI {ECO:0000303|PubMed:9450349};
GN Name=APC13 {ECO:0000303|PubMed:17627280};
GN Synonyms=BNS {ECO:0000303|PubMed:9450349};
GN OrderedLocusNames=At1g73177 {ECO:0000312|Araport:AT1G73177};
GN ORFNames=T18K17;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAM66119.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=9450349; DOI=10.1046/j.1365-313x.1997.12061447.x;
RA Kakutani T.;
RT "Genetic characterization of late-flowering traits induced by DNA
RT hypomethylation mutation in Arabidopsis thaliana.";
RL Plant J. 12:1447-1451(1997).
RN [6]
RP DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=16117643; DOI=10.1101/sqb.2004.69.139;
RA Kakutani T., Kato M., Kinoshita T., Miura A.;
RT "Control of development and transposon movement by DNA methylation in
RT Arabidopsis thaliana.";
RL Cold Spring Harb. Symp. Quant. Biol. 69:139-143(2004).
RN [7]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND INDUCTION BY
RP EPIGENETIC METHYLATION.
RC STRAIN=cv. Columbia;
RX PubMed=17627280; DOI=10.1038/sj.emboj.7601788;
RA Saze H., Kakutani T.;
RT "Heritable epigenetic mutation of a transposon-flanked Arabidopsis gene due
RT to lack of the chromatin-remodeling factor DDM1.";
RL EMBO J. 26:3641-3652(2007).
RN [8]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia;
RX PubMed=21441434; DOI=10.1105/tpc.111.083980;
RA Zheng B., Chen X., McCormick S.;
RT "The anaphase-promoting complex is a dual integrator that regulates both
RT MicroRNA-mediated transcriptional regulation of cyclin B1 and degradation
RT of Cyclin B1 during Arabidopsis male gametophyte development.";
RL Plant Cell 23:1033-1046(2011).
RN [9]
RP INDUCTION BY EPIGENETIC METHYLATION.
RX PubMed=22269081; DOI=10.1111/j.1365-313x.2012.04911.x;
RA Sasaki T., Kobayashi A., Saze H., Kakutani T.;
RT "RNAi-independent de novo DNA methylation revealed in Arabidopsis mutants
RT of chromatin remodeling gene DDM1.";
RL Plant J. 70:750-758(2012).
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC progression through mitosis and the G1 phase of the cell cycle. The
CC APC/C complex acts by mediating ubiquitination and subsequent
CC degradation of target proteins (By similarity). Regulates global growth
CC and development, including phyllotaxis and apical dominance
CC (PubMed:17627280). Required for pollen maturation. Promotes (pri) miRNA
CC transcription of each MIR159 genes (PubMed:21441434).
CC {ECO:0000250|UniProtKB:Q9BS18, ECO:0000269|PubMed:17627280,
CC ECO:0000269|PubMed:21441434}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000250|UniProtKB:Q9BS18}.
CC -!- SUBUNIT: Component of the anaphase promoting complex/cyclosome (APC/C)
CC complex. {ECO:0000250|UniProtKB:Q9BS18}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BS18}.
CC -!- TISSUE SPECIFICITY: Expressed constitutively in roots, leaves, stems,
CC buds, flowers, and seeds. {ECO:0000269|PubMed:17627280}.
CC -!- INDUCTION: Regulated by epigenetic histone methylation on H3K9me in a
CC KYP and CMT3-dependent manner. {ECO:0000269|PubMed:17627280,
CC ECO:0000269|PubMed:22269081}.
CC -!- DISRUPTION PHENOTYPE: Abnormalities in shoot and inflorescence
CC development leading to the 'bonsai' phenotype characterized by short,
CC compact inflorescence, resulting in reduced plant height, disrupted
CC phyllotaxis, reduced apical dominance and production of clusters of
CC bracts and flowers at the apex of the inflorescence (PubMed:17627280,
CC PubMed:16117643, PubMed:9450349). Reduced seed set mostly due to
CC impaired pollen maturation and thus abnormal male transmission. Defects
CC in mature miRNA miR159 accumulation (PubMed:21441434).
CC {ECO:0000269|PubMed:16117643, ECO:0000269|PubMed:17627280,
CC ECO:0000269|PubMed:21441434, ECO:0000269|PubMed:9450349}.
CC -!- SIMILARITY: Belongs to the APC13 family. {ECO:0000305}.
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DR EMBL; AC010556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; AEE35424.1; -; Genomic_DNA.
DR EMBL; BT025015; ABE02390.1; -; mRNA.
DR EMBL; AY088589; AAM66119.1; -; mRNA.
DR RefSeq; NP_565057.1; NM_105976.3.
DR AlphaFoldDB; Q8L981; -.
DR SMR; Q8L981; -.
DR STRING; 3702.AT1G73177.1; -.
DR PaxDb; Q8L981; -.
DR PRIDE; Q8L981; -.
DR ProteomicsDB; 244461; -.
DR EnsemblPlants; AT1G73177.1; AT1G73177.1; AT1G73177.
DR GeneID; 843651; -.
DR Gramene; AT1G73177.1; AT1G73177.1; AT1G73177.
DR KEGG; ath:AT1G73177; -.
DR Araport; AT1G73177; -.
DR TAIR; locus:505006219; AT1G73177.
DR eggNOG; ENOG502S8ST; Eukaryota.
DR HOGENOM; CLU_183994_0_0_1; -.
DR InParanoid; Q8L981; -.
DR OMA; TEDSNHE; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q8L981; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8L981; baseline and differential.
DR GO; GO:0005680; C:anaphase-promoting complex; ISS:TAIR.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0010229; P:inflorescence development; IMP:TAIR.
DR GO; GO:0061614; P:miRNA transcription; IMP:UniProtKB.
DR GO; GO:0048827; P:phyllome development; IMP:TAIR.
DR GO; GO:0010152; P:pollen maturation; IMP:UniProtKB.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR InterPro; IPR008401; Apc13.
DR PANTHER; PTHR28672; PTHR28672; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Developmental protein; Mitosis; Nucleus;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..63
FT /note="Anaphase-promoting complex subunit 13"
FT /id="PRO_0000436433"
FT REGION 36..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 63 AA; 7145 MW; AF4341E2220E7ECA CRC64;
MAEVSLGMLI DIVDEEWMRD TLPDDDLPLP PVLAVKTDDT EETNQETQQA DAETWRDLAL
DTQ
