ID3_XENTR
ID ID3_XENTR Reviewed; 118 AA.
AC Q688C4;
DT 19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=DNA-binding protein inhibitor ID-3 {ECO:0000250|UniProtKB:Q02535};
DE AltName: Full=Inhibitor of DNA binding 3 {ECO:0000250|UniProtKB:Q91399};
DE AltName: Full=Inhibitor of differentiation 3;
GN Name=id3; ORFNames=TGas044c15.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:AAU12853.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Qin S., Dors M., Johnson E., Bloom S., Hood L., Rowen L.;
RT "Sequence of Xenopus tropicalis development genes.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:AAU12853.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula {ECO:0000312|EMBL:CAJ83590.1};
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000312|EMBL:AAU12853.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional regulator (lacking a basic DNA binding
CC domain) which negatively regulates the basic helix-loop-helix (bHLH)
CC transcription factors by forming heterodimers and inhibiting their DNA
CC binding and transcriptional activity. Influences cell fate decisions in
CC the embryo by sequestering and blocking the activity of the bHLH
CC transcription factors that control these decisions. Inhibits the
CC binding of myogenic bHLH-containing complexes to E-box DNA, thereby
CC preventing activation of muscle-specific target genes. Also inhibits
CC the activity of neurogenic factor neurod1/neuroD. Plays a role in cell
CC cycle progression and survival of neural crest progenitors; binding to
CC either hes4-B/hairy2b or stat3 blocks the formation of transcription
CC factor complexes and the repressor function of hes4-B/hairy2B, to allow
CC neural crest progenitors to differentiate. May play a role in the
CC regulation of the circadian rhythm (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer (By similarity). Heterodimer with other HLH
CC proteins. Interacts (via HLH domain) with the bHLH protein hes4/hairy2
CC (via Orange domain). Interacts with stat3 (By similarity).
CC {ECO:0000250|UniProtKB:Q91399}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q02535,
CC ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR EMBL; AC151468; AAU12853.1; -; Genomic_DNA.
DR EMBL; CR761665; CAJ83590.1; -; mRNA.
DR EMBL; BC170654; AAI70654.1; -; mRNA.
DR EMBL; BC170656; AAI70656.1; -; mRNA.
DR RefSeq; NP_001016271.1; NM_001016271.2.
DR AlphaFoldDB; Q688C4; -.
DR SMR; Q688C4; -.
DR STRING; 8364.ENSXETP00000044625; -.
DR PaxDb; Q688C4; -.
DR Ensembl; ENSXETT00000044625; ENSXETP00000044625; ENSXETG00000020653.
DR GeneID; 549025; -.
DR KEGG; xtr:549025; -.
DR CTD; 3399; -.
DR Xenbase; XB-GENE-495261; id3.
DR eggNOG; ENOG502S53I; Eukaryota.
DR HOGENOM; CLU_116790_1_0_1; -.
DR InParanoid; Q688C4; -.
DR OMA; EPMGLLY; -.
DR OrthoDB; 1624054at2759; -.
DR PhylomeDB; Q688C4; -.
DR TreeFam; TF326217; -.
DR Proteomes; UP000008143; Chromosome 2.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000020653; Expressed in gastrula and 32 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043425; F:bHLH transcription factor binding; ISS:UniProtKB.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0032922; P:circadian regulation of gene expression; IBA:GO_Central.
DR GO; GO:0043392; P:negative regulation of DNA binding; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0014029; P:neural crest formation; ISS:UniProtKB.
DR GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR026052; DNA-bd_prot-inh.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR11723; PTHR11723; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW Biological rhythms; Developmental protein; Nucleus; Reference proteome;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1..118
FT /note="DNA-binding protein inhibitor ID-3"
FT /id="PRO_0000390726"
FT DOMAIN 32..84
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
SQ SEQUENCE 118 AA; 12849 MW; 79E50B9F6434E6F1 CRC64;
MKAISPVRSM SSCYQAVCCL SEQSLSIARG SSHKGPGVDE PMGLLYDMNG CYSKLKELVP
GIPQGSKLSQ VEILQHVIDY IFDLQIVLGE DQQQNSILNL QKSDFSELAT QGDASVCH
