ID4_MOUSE
ID ID4_MOUSE Reviewed; 161 AA.
AC P41139;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=DNA-binding protein inhibitor ID-4;
DE AltName: Full=Inhibitor of DNA binding 4;
DE AltName: Full=Inhibitor of differentiation 4;
GN Name=Id4; Synonyms=Id-4, Idb4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Bone marrow;
RX PubMed=8139914; DOI=10.1093/nar/22.5.749;
RA Riechmann V., van Cruechten I., Sablitzky F.;
RT "The expression pattern of Id4, a novel dominant negative helix-loop-helix
RT protein, is distinct from Id1, Id2 and Id3.";
RL Nucleic Acids Res. 22:749-755(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9838043; DOI=10.1016/s0167-4781(98)00196-1;
RA van Cruechten I., Cinato E., Fox M., King E.R., Newton J.S., Riechmann V.,
RA Sablitzky F.;
RT "Structure, chromosomal localisation and expression of the murine dominant
RT negative helix-loop-helix Id4 gene.";
RL Biochim. Biophys. Acta 1443:55-64(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9831657; DOI=10.1016/s0378-1119(98)00488-0;
RA Mantani A., Hernandez M.-C., Kuo W.-L., Israel M.A.;
RT "The mouse Id2 and Id4 genes: structural organization and chromosomal
RT localization.";
RL Gene 222:229-235(1998).
RN [4]
RP INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=19217292; DOI=10.1016/j.cub.2008.12.052;
RA Duffield G.E., Watson N.P., Mantani A., Peirson S.N., Robles-Murguia M.,
RA Loros J.J., Israel M.A., Dunlap J.C.;
RT "A role for Id2 in regulating photic entrainment of the mammalian circadian
RT system.";
RL Curr. Biol. 19:297-304(2009).
CC -!- FUNCTION: Transcriptional regulator (lacking a basic DNA binding
CC domain) which negatively regulates the basic helix-loop-helix (bHLH)
CC transcription factors by forming heterodimers and inhibiting their DNA
CC binding and transcriptional activity. Implicated in regulating a
CC variety of cellular processes, including cellular growth, senescence,
CC differentiation, apoptosis, angiogenesis, and neoplastic
CC transformation.
CC -!- SUBUNIT: Heterodimer with other HLH proteins.
CC -!- INTERACTION:
CC P41139; Q9JKN5: Olig1; NbExp=5; IntAct=EBI-1213725, EBI-1213712;
CC P41139; Q9EQW6: Olig2; NbExp=5; IntAct=EBI-1213725, EBI-1213740;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- INDUCTION: Expressed in a circadian manner in the suprachiasmatic
CC nucleus (SCN) of the brain with peak levels between CT16 and CT20.
CC {ECO:0000269|PubMed:19217292}.
CC -!- DISRUPTION PHENOTYPE: Mice do not exhibit a noticeable circadian
CC phenotype. {ECO:0000269|PubMed:19217292}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X75018; CAA52926.1; -; mRNA.
DR EMBL; AJ001972; CAA05120.1; -; Genomic_DNA.
DR EMBL; AF077859; AAD05213.1; -; Genomic_DNA.
DR CCDS; CCDS26492.1; -.
DR PIR; S43260; S43260.
DR RefSeq; NP_112443.1; NM_031166.2.
DR AlphaFoldDB; P41139; -.
DR SMR; P41139; -.
DR BioGRID; 200508; 2.
DR IntAct; P41139; 3.
DR STRING; 10090.ENSMUSP00000021810; -.
DR PhosphoSitePlus; P41139; -.
DR PaxDb; P41139; -.
DR PeptideAtlas; P41139; -.
DR PRIDE; P41139; -.
DR ProteomicsDB; 273262; -.
DR Antibodypedia; 10414; 384 antibodies from 32 providers.
DR DNASU; 15904; -.
DR Ensembl; ENSMUST00000021810; ENSMUSP00000021810; ENSMUSG00000021379.
DR GeneID; 15904; -.
DR KEGG; mmu:15904; -.
DR UCSC; uc007qid.1; mouse.
DR CTD; 3400; -.
DR MGI; MGI:99414; Id4.
DR VEuPathDB; HostDB:ENSMUSG00000021379; -.
DR eggNOG; ENOG502S1WX; Eukaryota.
DR GeneTree; ENSGT00940000162435; -.
DR HOGENOM; CLU_116790_2_0_1; -.
DR InParanoid; P41139; -.
DR OMA; ARCKMEE; -.
DR OrthoDB; 1624054at2759; -.
DR PhylomeDB; P41139; -.
DR TreeFam; TF326217; -.
DR BioGRID-ORCS; 15904; 1 hit in 70 CRISPR screens.
DR ChiTaRS; Id4; mouse.
DR PRO; PR:P41139; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; P41139; protein.
DR Bgee; ENSMUSG00000021379; Expressed in ureter smooth muscle and 279 other tissues.
DR ExpressionAtlas; P41139; baseline and differential.
DR Genevisible; P41139; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IPI:MGI.
DR GO; GO:0140416; F:transcription regulator inhibitor activity; ISO:MGI.
DR GO; GO:0048708; P:astrocyte differentiation; IGI:MGI.
DR GO; GO:0007420; P:brain development; IMP:MGI.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0008283; P:cell population proliferation; IMP:MGI.
DR GO; GO:0022010; P:central nervous system myelination; IMP:MGI.
DR GO; GO:0021895; P:cerebral cortex neuron differentiation; IMP:MGI.
DR GO; GO:0032922; P:circadian regulation of gene expression; IBA:GO_Central.
DR GO; GO:0007623; P:circadian rhythm; IEP:UniProtKB.
DR GO; GO:0045444; P:fat cell differentiation; IMP:MGI.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:MGI.
DR GO; GO:0021766; P:hippocampus development; IMP:MGI.
DR GO; GO:0048712; P:negative regulation of astrocyte differentiation; IGI:MGI.
DR GO; GO:0045599; P:negative regulation of fat cell differentiation; IMP:MGI.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IMP:MGI.
DR GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; IMP:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0007405; P:neuroblast proliferation; IMP:MGI.
DR GO; GO:0030182; P:neuron differentiation; IMP:MGI.
DR GO; GO:0048709; P:oligodendrocyte differentiation; IMP:MGI.
DR GO; GO:0001649; P:osteoblast differentiation; IMP:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:MGI.
DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IMP:MGI.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IGI:MGI.
DR GO; GO:0060740; P:prostate gland epithelium morphogenesis; IMP:MGI.
DR GO; GO:0060512; P:prostate gland morphogenesis; IMP:MGI.
DR GO; GO:0060741; P:prostate gland stromal morphogenesis; IMP:MGI.
DR GO; GO:0008104; P:protein localization; IMP:MGI.
DR GO; GO:0061682; P:seminal vesicle morphogenesis; IMP:MGI.
DR GO; GO:0072089; P:stem cell proliferation; IMP:MGI.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR026052; DNA-bd_prot-inh.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR11723; PTHR11723; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..161
FT /note="DNA-binding protein inhibitor ID-4"
FT /id="PRO_0000127251"
FT DOMAIN 52..104
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
SQ SEQUENCE 161 AA; 16596 MW; 2DCFF47AF7EE7EED CRC64;
MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC KAAEAAADEP
ALCLQCDMND CYSRLRRLVP TIPPNKKVSK VEILQHVIDY ILDLQLALET HPALLRQPPP
PAPPLHPAGA CPVAPPRTPL TALNTDPAGA VNKQGDSILC R
