ID   ID4_PIG                 Reviewed;         161 AA.
AC   Q06AV5;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=DNA-binding protein inhibitor ID-4;
DE   AltName: Full=Inhibitor of DNA binding 4;
DE   AltName: Full=Inhibitor of differentiation 4;
GN   Name=ID4;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Liu G.Y.;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional regulator (lacking a basic DNA binding
CC       domain) which negatively regulates the basic helix-loop-helix (bHLH)
CC       transcription factors by forming heterodimers and inhibiting their DNA
CC       binding and transcriptional activity. Implicated in regulating a
CC       variety of cellular processes, including cellular growth, senescence,
CC       differentiation, apoptosis, angiogenesis, and neoplastic transformation
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with other HLH proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR   EMBL; DQ917620; ABI97165.1; -; mRNA.
DR   RefSeq; NP_001116602.1; NM_001123130.1.
DR   AlphaFoldDB; Q06AV5; -.
DR   SMR; Q06AV5; -.
DR   STRING; 9823.ENSSSCP00000021281; -.
DR   PaxDb; Q06AV5; -.
DR   GeneID; 100144508; -.
DR   KEGG; ssc:100144508; -.
DR   CTD; 3400; -.
DR   eggNOG; ENOG502S1WX; Eukaryota.
DR   InParanoid; Q06AV5; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR026052; DNA-bd_prot-inh.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   PANTHER; PTHR11723; PTHR11723; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..161
FT                   /note="DNA-binding protein inhibitor ID-4"
FT                   /id="PRO_0000269177"
FT   DOMAIN          52..104
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          116..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..134
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   161 AA;  16591 MW;  5B1485CB5732C289 CRC64;
     MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC KAAEAAADEP
     ALCLQCDMND CYSRLRRLVP TIPPNKKVSK VEILPHVIDY ILDLQLALET HPALLRQPPP
     PAPPHHPAGT CPAAPPRTPL TALNTDPAGA VNKQGDSILC R