ID4_XENTR
ID ID4_XENTR Reviewed; 131 AA.
AC Q6GL62;
DT 19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=DNA-binding protein inhibitor ID-4 {ECO:0000250|UniProtKB:P47928};
DE AltName: Full=Inhibitor of DNA binding 4 {ECO:0000250|UniProtKB:P47928};
DE AltName: Full=Inhibitor of differentiation 4;
GN Name=id4 {ECO:0000312|EMBL:CAJ82918.1}; ORFNames=TTpA009j06.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:CAJ82918.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tadpole {ECO:0000312|EMBL:CAJ82918.1};
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:CAJ82918.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tail bud {ECO:0000312|EMBL:AAH74645.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional regulator (lacking a basic DNA binding
CC domain) which negatively regulates the basic helix-loop-helix (bHLH)
CC transcription factors by forming heterodimers and inhibiting their DNA
CC binding and transcriptional activity. Inhibits the activity of both
CC neurogenic (neurog1/neurogenin, neurod1/neuroD) and myogenic
CC (myod1/myoD) bHLH factors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer with other HLH proteins.
CC {ECO:0000250|UniProtKB:P47928}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P47928,
CC ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR EMBL; CR760882; CAJ82918.1; -; mRNA.
DR EMBL; BC074645; AAH74645.1; -; mRNA.
DR RefSeq; NP_001004839.1; NM_001004839.1.
DR AlphaFoldDB; Q6GL62; -.
DR SMR; Q6GL62; -.
DR PaxDb; Q6GL62; -.
DR DNASU; 448114; -.
DR Ensembl; ENSXETT00000054646; ENSXETP00000054646; ENSXETG00000025736.
DR GeneID; 448114; -.
DR KEGG; xtr:448114; -.
DR CTD; 3400; -.
DR Xenbase; XB-GENE-876360; id4.
DR eggNOG; ENOG502S1WX; Eukaryota.
DR HOGENOM; CLU_116790_2_0_1; -.
DR InParanoid; Q6GL62; -.
DR OrthoDB; 1624054at2759; -.
DR PhylomeDB; Q6GL62; -.
DR Proteomes; UP000008143; Chromosome 6.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000025736; Expressed in brain and 9 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043425; F:bHLH transcription factor binding; ISS:UniProtKB.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0032922; P:circadian regulation of gene expression; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR026052; DNA-bd_prot-inh.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR11723; PTHR11723; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..131
FT /note="DNA-binding protein inhibitor ID-4"
FT /id="PRO_0000390728"
FT DOMAIN 36..88
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
SQ SEQUENCE 131 AA; 14740 MW; 89694E0B7B822D74 CRC64;
MKAVSPVRPQ SRKAQVPAVC GELALHCLSE HSLGVARYKM EEEETLCLQY DMNDCYSRLK
RLVPTIPPNK KVSKVEILQH VIDYILDLQL ALDTHPVLLR QQPPTRTPLT DLNTDPAALV
VNKQGDSILC R
