APC13_MOUSE
ID APC13_MOUSE Reviewed; 74 AA.
AC Q8R034;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Anaphase-promoting complex subunit 13;
DE Short=APC13;
DE AltName: Full=Cyclosome subunit 13;
GN Name=Anapc13;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC progression through mitosis and the G1 phase of the cell cycle. The
CC APC/C complex acts by mediating ubiquitination and subsequent
CC degradation of target proteins: it mainly mediates the formation of
CC 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By
CC similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: The mammalian APC/C is composed at least of 14 distinct
CC subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6,
CC ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and
CC ANAPC16 that assemble into a complex of at least 19 chains with a
CC combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1
CC and FBXO5. {ECO:0000250|UniProtKB:Q9BS18}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the APC13 family. {ECO:0000305}.
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DR EMBL; AK007332; BAC25171.1; -; mRNA.
DR EMBL; BC028526; AAH28526.1; -; mRNA.
DR CCDS; CCDS40744.1; -.
DR RefSeq; NP_852059.1; NM_181394.3.
DR RefSeq; XP_006511869.1; XM_006511806.3.
DR RefSeq; XP_006511870.1; XM_006511807.3.
DR AlphaFoldDB; Q8R034; -.
DR SMR; Q8R034; -.
DR BioGRID; 213171; 28.
DR IntAct; Q8R034; 25.
DR STRING; 10090.ENSMUSP00000140967; -.
DR PhosphoSitePlus; Q8R034; -.
DR MaxQB; Q8R034; -.
DR PaxDb; Q8R034; -.
DR PeptideAtlas; Q8R034; -.
DR PRIDE; Q8R034; -.
DR ProteomicsDB; 296265; -.
DR Antibodypedia; 49243; 78 antibodies from 24 providers.
DR Ensembl; ENSMUST00000038673; ENSMUSP00000039761; ENSMUSG00000035048.
DR Ensembl; ENSMUST00000186693; ENSMUSP00000139762; ENSMUSG00000035048.
DR Ensembl; ENSMUST00000188398; ENSMUSP00000140325; ENSMUSG00000035048.
DR Ensembl; ENSMUST00000190279; ENSMUSP00000140967; ENSMUSG00000035048.
DR GeneID; 69010; -.
DR KEGG; mmu:69010; -.
DR UCSC; uc009rft.2; mouse.
DR CTD; 25847; -.
DR MGI; MGI:1916260; Anapc13.
DR VEuPathDB; HostDB:ENSMUSG00000035048; -.
DR eggNOG; ENOG502S4J1; Eukaryota.
DR GeneTree; ENSGT00390000008673; -.
DR HOGENOM; CLU_199969_0_0_1; -.
DR InParanoid; Q8R034; -.
DR OMA; PHDDIAV; -.
DR OrthoDB; 1635284at2759; -.
DR PhylomeDB; Q8R034; -.
DR TreeFam; TF105448; -.
DR Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 69010; 17 hits in 68 CRISPR screens.
DR ChiTaRS; Anapc13; mouse.
DR PRO; PR:Q8R034; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8R034; protein.
DR Bgee; ENSMUSG00000035048; Expressed in embryonic brain and 264 other tissues.
DR Genevisible; Q8R034; MM.
DR GO; GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.
DR InterPro; IPR008401; Apc13.
DR PANTHER; PTHR28672; PTHR28672; 1.
DR Pfam; PF05839; Apc13p; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Mitosis; Nucleus; Reference proteome;
KW Ubl conjugation pathway.
FT CHAIN 1..74
FT /note="Anaphase-promoting complex subunit 13"
FT /id="PRO_0000253981"
FT REGION 33..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 74 AA; 8346 MW; E84F16A13821CB3B CRC64;
MDSEVQRDGR ILDLIDDAWR EDKLPYEDVA IPLSELPEPE QDNGGTTESV KEQEMKWTDL
ALQGLHENVP PAGN