ID   APC13_PONAB             Reviewed;          74 AA.
AC   Q5RBV4;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Anaphase-promoting complex subunit 13;
DE            Short=APC13;
DE   AltName: Full=Cyclosome subunit 13;
GN   Name=ANAPC13;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC       (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC       progression through mitosis and the G1 phase of the cell cycle. The
CC       APC/C complex acts by mediating ubiquitination and subsequent
CC       degradation of target proteins: it mainly mediates the formation of
CC       'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC       formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By
CC       similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: The mammalian APC/C is composed at least of 14 distinct
CC       subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6,
CC       ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and
CC       ANAPC16 that assemble into a complex of at least 19 chains with a
CC       combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1
CC       and FBXO5. {ECO:0000250|UniProtKB:Q9BS18}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the APC13 family. {ECO:0000305}.
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DR   EMBL; CR858529; CAH90756.1; -; mRNA.
DR   RefSeq; NP_001127330.1; NM_001133858.1.
DR   AlphaFoldDB; Q5RBV4; -.
DR   SMR; Q5RBV4; -.
DR   STRING; 9601.ENSPPYP00000015799; -.
DR   GeneID; 100174391; -.
DR   KEGG; pon:100174391; -.
DR   CTD; 25847; -.
DR   eggNOG; ENOG502S4J1; Eukaryota.
DR   InParanoid; Q5RBV4; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.
DR   InterPro; IPR008401; Apc13.
DR   PANTHER; PTHR28672; PTHR28672; 1.
DR   Pfam; PF05839; Apc13p; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Mitosis; Nucleus; Reference proteome;
KW   Ubl conjugation pathway.
FT   CHAIN           1..74
FT                   /note="Anaphase-promoting complex subunit 13"
FT                   /id="PRO_0000253982"
FT   REGION          33..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   74 AA;  8507 MW;  F3C52A7E398AD18B CRC64;
     MDSEVQRDGR ILDLIDDAWR EDKLPYEDVA IPLNELPDPE QDNGGTTESV KEQEMKWTDL
     ALQYLHENVP PIGN