ID   IDER_MYCBO              Reviewed;         230 AA.
AC   P0A673; A0A1R3Y2D9; O08190; Q50495; X2BLC3;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Iron-dependent repressor IdeR;
GN   Name=ideR; Synonyms=dtxR; OrderedLocusNames=BQ2027_MB2730;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Metal-dependent DNA-binding protein that controls
CC       transcription of many genes involved in iron metabolism. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DtxR/MntR family. {ECO:0000305}.
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DR   EMBL; LT708304; SIU01348.1; -; Genomic_DNA.
DR   RefSeq; NP_856376.1; NC_002945.3.
DR   RefSeq; WP_003413962.1; NC_002945.4.
DR   AlphaFoldDB; P0A673; -.
DR   SMR; P0A673; -.
DR   PRIDE; P0A673; -.
DR   EnsemblBacteria; SIU01348; SIU01348; BQ2027_MB2730.
DR   GeneID; 45426698; -.
DR   PATRIC; fig|233413.5.peg.2992; -.
DR   OMA; DAQLMYT; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.60.10; -; 1.
DR   Gene3D; 2.30.30.90; -; 1.
DR   InterPro; IPR040767; DtxR_SH3.
DR   InterPro; IPR007167; Fe-transptr_FeoA.
DR   InterPro; IPR001367; Fe_dep_repressor.
DR   InterPro; IPR036421; Fe_dep_repressor_sf.
DR   InterPro; IPR038157; FeoA_core_dom.
DR   InterPro; IPR022687; HTH_DTXR.
DR   InterPro; IPR022689; Iron_dep_repressor.
DR   InterPro; IPR008988; Transcriptional_repressor_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF18357; DtxR; 1.
DR   Pfam; PF02742; Fe_dep_repr_C; 1.
DR   Pfam; PF01325; Fe_dep_repress; 1.
DR   SMART; SM00899; FeoA; 1.
DR   SMART; SM00529; HTH_DTXR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47979; SSF47979; 1.
DR   SUPFAM; SSF50037; SSF50037; 1.
DR   PROSITE; PS50944; HTH_DTXR; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Iron; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..230
FT                   /note="Iron-dependent repressor IdeR"
FT                   /id="PRO_0000201109"
FT   DOMAIN          4..65
FT                   /note="HTH dtxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00296"
SQ   SEQUENCE   230 AA;  25233 MW;  77B9CA98E04BDC27 CRC64;
     MNELVDTTEM YLRTIYDLEE EGVTPLRARI AERLDQSGPT VSQTVSRMER DGLLRVAGDR
     HLELTEKGRA LAIAVMRKHR LAERLLVDVI GLPWEEVHAE ACRWEHVMSE DVERRLVKVL
     NNPTTSPFGN PIPGLVELGV GPEPGADDAN LVRLTELPAG SPVAVVVRQL TEHVQGDIDL
     ITRLKDAGVV PNARVTVETT PGGGVTIVIP GHENVTLPHE MAHAVKVEKV