IDER_MYCLE
ID IDER_MYCLE Reviewed; 230 AA.
AC Q9CCB5;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Iron-dependent repressor IdeR;
GN Name=ideR; OrderedLocusNames=ML1013;
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=272631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
CC -!- FUNCTION: Metal-dependent DNA-binding protein that controls
CC transcription of many genes involved in iron metabolism. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DtxR/MntR family. {ECO:0000305}.
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DR EMBL; AL583920; CAC31394.1; -; Genomic_DNA.
DR PIR; G87035; G87035.
DR RefSeq; NP_301749.1; NC_002677.1.
DR RefSeq; WP_010908073.1; NC_002677.1.
DR AlphaFoldDB; Q9CCB5; -.
DR SMR; Q9CCB5; -.
DR STRING; 272631.ML1013; -.
DR EnsemblBacteria; CAC31394; CAC31394; CAC31394.
DR KEGG; mle:ML1013; -.
DR PATRIC; fig|272631.5.peg.1843; -.
DR Leproma; ML1013; -.
DR eggNOG; COG1321; Bacteria.
DR HOGENOM; CLU_069532_0_0_11; -.
DR OMA; NIIPACD; -.
DR Proteomes; UP000000806; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.60.10; -; 1.
DR Gene3D; 2.30.30.90; -; 1.
DR InterPro; IPR040767; DtxR_SH3.
DR InterPro; IPR007167; Fe-transptr_FeoA.
DR InterPro; IPR001367; Fe_dep_repressor.
DR InterPro; IPR036421; Fe_dep_repressor_sf.
DR InterPro; IPR038157; FeoA_core_dom.
DR InterPro; IPR022687; HTH_DTXR.
DR InterPro; IPR022689; Iron_dep_repressor.
DR InterPro; IPR008988; Transcriptional_repressor_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF18357; DtxR; 1.
DR Pfam; PF02742; Fe_dep_repr_C; 1.
DR Pfam; PF01325; Fe_dep_repress; 1.
DR SMART; SM00899; FeoA; 1.
DR SMART; SM00529; HTH_DTXR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF47979; SSF47979; 1.
DR SUPFAM; SSF50037; SSF50037; 1.
DR PROSITE; PS50944; HTH_DTXR; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Iron; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..230
FT /note="Iron-dependent repressor IdeR"
FT /id="PRO_0000201107"
FT DOMAIN 4..65
FT /note="HTH dtxR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00296"
SQ SEQUENCE 230 AA; 25354 MW; 6E2D0949B75D6D13 CRC64;
MNDLVDTTEM YLRTIYDLEE EGVTPLRARI AERLEQSGPT VSQTVSRMER DGLLRVAGNR
HLELTTKGRA MAIAVMRKHR LAERLLVDVI GLPWEEVHAE ACRWEHVMSE DVERRLIKVL
NNPTTSPFGN PIPGLLDLGA GPDASAANAK LVRLTELPSG SPVAVVVRQL TEHVQDDIDL
ITRLKDTGVV PNARVTVETS PAGNVIIIIP GHENVTLPHE MAHAVKVEKV
