ID   IDER_MYCTO              Reviewed;         230 AA.
AC   P9WMH0; L0TC16; O08190; P0A672; Q50495;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Iron-dependent repressor IdeR;
GN   Name=ideR; Synonyms=dtxR; OrderedLocusNames=MT2784;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Metal-dependent DNA-binding protein that controls
CC       transcription of many genes involved in iron metabolism. Acts as a
CC       repressor of siderophore biosynthesis and as a positive modulator of
CC       iron storage. Also regulates expression of transporters, proteins
CC       involved in siderophore synthesis, iron storage and transcriptional
CC       regulators (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DtxR/MntR family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK47100.1; -; Genomic_DNA.
DR   PIR; B70532; B70532.
DR   RefSeq; WP_003413962.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMH0; -.
DR   SMR; P9WMH0; -.
DR   EnsemblBacteria; AAK47100; AAK47100; MT2784.
DR   GeneID; 45426698; -.
DR   KEGG; mtc:MT2784; -.
DR   PATRIC; fig|83331.31.peg.2997; -.
DR   HOGENOM; CLU_069532_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.60.10; -; 1.
DR   Gene3D; 2.30.30.90; -; 1.
DR   InterPro; IPR040767; DtxR_SH3.
DR   InterPro; IPR007167; Fe-transptr_FeoA.
DR   InterPro; IPR001367; Fe_dep_repressor.
DR   InterPro; IPR036421; Fe_dep_repressor_sf.
DR   InterPro; IPR038157; FeoA_core_dom.
DR   InterPro; IPR022687; HTH_DTXR.
DR   InterPro; IPR022689; Iron_dep_repressor.
DR   InterPro; IPR008988; Transcriptional_repressor_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF18357; DtxR; 1.
DR   Pfam; PF02742; Fe_dep_repr_C; 1.
DR   Pfam; PF01325; Fe_dep_repress; 1.
DR   SMART; SM00899; FeoA; 1.
DR   SMART; SM00529; HTH_DTXR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47979; SSF47979; 1.
DR   SUPFAM; SSF50037; SSF50037; 1.
DR   PROSITE; PS50944; HTH_DTXR; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Iron; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..230
FT                   /note="Iron-dependent repressor IdeR"
FT                   /id="PRO_0000427305"
FT   DOMAIN          4..65
FT                   /note="HTH dtxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00296"
SQ   SEQUENCE   230 AA;  25233 MW;  77B9CA98E04BDC27 CRC64;
     MNELVDTTEM YLRTIYDLEE EGVTPLRARI AERLDQSGPT VSQTVSRMER DGLLRVAGDR
     HLELTEKGRA LAIAVMRKHR LAERLLVDVI GLPWEEVHAE ACRWEHVMSE DVERRLVKVL
     NNPTTSPFGN PIPGLVELGV GPEPGADDAN LVRLTELPAG SPVAVVVRQL TEHVQGDIDL
     ITRLKDAGVV PNARVTVETT PGGGVTIVIP GHENVTLPHE MAHAVKVEKV