APC13_SCHPO
ID APC13_SCHPO Reviewed; 135 AA.
AC O74358;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Anaphase-promoting complex subunit 13;
DE AltName: Full=20S cyclosome/APC complex protein apc13;
GN Name=apc13; ORFNames=SPBC28E12.01c, SPBC9B6.12c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, AND SUBUNIT.
RX PubMed=12477395; DOI=10.1016/s0960-9822(02)01331-3;
RA Yoon H.-J., Feoktistova A., Wolfe B.A., Jennings J.L., Link A.J.,
RA Gould K.L.;
RT "Proteomics analysis identifies new components of the fission and budding
RT yeast anaphase-promoting complexes.";
RL Curr. Biol. 12:2048-2054(2002).
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex
CC that controls progression through mitosis and the G1 phase of the cell
CC cycle. The APC/C is thought to confer substrate specificity and, in the
CC presence of ubiquitin-conjugating E2 enzymes, it catalyzes the
CC formation of protein-ubiquitin conjugates that are subsequently
CC degraded by the 26S proteasome. {ECO:0000269|PubMed:12477395}.
CC -!- SUBUNIT: The APC/C is composed of at least 13 subunits: apc1, apc2,
CC nuc2, apc4, apc5, cut9, apc8, apc10, apc11, hcn1, apc13, apc14 and
CC apc15. {ECO:0000269|PubMed:12477395}.
CC -!- INTERACTION:
CC O74358; O94688: apc15; NbExp=3; IntAct=EBI-1251583, EBI-1251604;
CC O74358; O42839: cut20; NbExp=4; IntAct=EBI-1251583, EBI-1251472;
CC -!- SIMILARITY: Belongs to the APC13 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB42373.1; -; Genomic_DNA.
DR PIR; T40038; T40038.
DR RefSeq; NP_595754.1; NM_001021654.1.
DR AlphaFoldDB; O74358; -.
DR BioGRID; 276816; 13.
DR ComplexPortal; CPX-763; Anaphase-Promoting Complex variant 1.
DR ComplexPortal; CPX-764; Anaphase-Promoting Complex variant 2.
DR ComplexPortal; CPX-765; Anaphase-Promoting Complex variant 3.
DR ComplexPortal; CPX-766; Anaphase-Promoting Complex variant 4.
DR IntAct; O74358; 12.
DR STRING; 4896.SPBC28E12.01c.1; -.
DR MaxQB; O74358; -.
DR PaxDb; O74358; -.
DR EnsemblFungi; SPBC28E12.01c.1; SPBC28E12.01c.1:pep; SPBC28E12.01c.
DR GeneID; 2540285; -.
DR KEGG; spo:SPBC28E12.01c; -.
DR PomBase; SPBC28E12.01c; apc13.
DR VEuPathDB; FungiDB:SPBC28E12.01c; -.
DR eggNOG; ENOG502S7KP; Eukaryota.
DR HOGENOM; CLU_1928797_0_0_1; -.
DR InParanoid; O74358; -.
DR OMA; LRHEPAW; -.
DR PRO; PR:O74358; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005680; C:anaphase-promoting complex; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IMP:PomBase.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR InterPro; IPR008401; Apc13.
DR Pfam; PF05839; Apc13p; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Mitosis; Reference proteome;
KW Ubl conjugation pathway.
FT CHAIN 1..135
FT /note="Anaphase-promoting complex subunit 13"
FT /id="PRO_0000237684"
SQ SEQUENCE 135 AA; 15628 MW; B3896BB1802BF3D8 CRC64;
MDSNYNYVHM NKPGVVLFAS DWLKDRLPVD DVEVRVEHLP PVTEDEMTIQ HSSANLILMK
NKQLRHEPAW KDLELEDLVN AFAFIQGSSN AEGKNTIEDN FETDPFKSVK EAPMAPFLEA
NRRHQGEHAS MRYFR
