IDGF1_DROYA
ID IDGF1_DROYA Reviewed; 439 AA.
AC Q8MX40;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Chitinase-like protein Idgf1;
DE AltName: Full=Imaginal disk growth factor protein 1;
DE Flags: Precursor;
GN Name=Idgf1;
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=#14021-0261.0;
RX PubMed=12242232; DOI=10.1093/genetics/162.1.177;
RA Zurovcova M., Ayala F.J.;
RT "Polymorphism patterns in two tightly linked developmental genes, Idgf1 and
RT Idgf3, of Drosophila melanogaster.";
RL Genetics 162:177-188(2002).
CC -!- FUNCTION: Cooperates with insulin-like peptides to stimulate the
CC proliferation, polarization and motility of imaginal disk cells. May
CC act by stabilizing the binding of insulin-like peptides to its receptor
CC through a simultaneous interaction with both molecules to form a
CC multiprotein signaling complex (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted in
CC hemolymph. It is probably transported to target tissues via hemolymph.
CC {ECO:0000250}.
CC -!- PTM: Glycosylated. {ECO:0000250}.
CC -!- MISCELLANEOUS: Lacks the typical Glu active site in position 150 that
CC is replaced by a Gln residue, preventing the hydrolase activity. Its
CC precise function remains unclear.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 18 family. IDGF
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF394712; AAM69644.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8MX40; -.
DR SMR; Q8MX40; -.
DR STRING; 7245.FBpp0258117; -.
DR CAZy; GH18; Glycoside Hydrolase Family 18.
DR eggNOG; KOG2806; Eukaryota.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008061; F:chitin binding; IEA:InterPro.
DR GO; GO:0008084; F:imaginal disc growth factor receptor binding; ISS:UniProtKB.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0040003; P:chitin-based cuticle development; IEA:EnsemblMetazoa.
DR GO; GO:0018990; P:ecdysis, chitin-based cuticle; IEA:EnsemblMetazoa.
DR GO; GO:1990399; P:epithelium regeneration; IEA:EnsemblMetazoa.
DR GO; GO:0007444; P:imaginal disc development; ISS:UniProtKB.
DR GO; GO:2000035; P:regulation of stem cell division; IEA:EnsemblMetazoa.
DR GO; GO:0042060; P:wound healing; IEA:EnsemblMetazoa.
DR CDD; cd02873; GH18_IDGF; 1.
DR Gene3D; 3.10.50.10; -; 1.
DR InterPro; IPR011583; Chitinase_II.
DR InterPro; IPR029070; Chitinase_insertion_sf.
DR InterPro; IPR001223; Glyco_hydro18_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR015520; IDGF.
DR PANTHER; PTHR11177:SF235; PTHR11177:SF235; 1.
DR Pfam; PF00704; Glyco_hydro_18; 1.
DR SMART; SM00636; Glyco_18; 1.
DR SUPFAM; SSF51445; SSF51445; 1.
DR SUPFAM; SSF54556; SSF54556; 1.
DR PROSITE; PS51910; GH18_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; Disulfide bond; Glycoprotein; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000250"
FT CHAIN 21..439
FT /note="Chitinase-like protein Idgf1"
FT /id="PRO_0000011982"
FT DOMAIN 22..439
FT /note="GH18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01258"
FT CARBOHYD 122
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 218
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250"
FT CARBOHYD 346
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 26..53
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01258"
FT DISULFID 340..423
FT /evidence="ECO:0000250"
SQ SEQUENCE 439 AA; 49244 MW; EDE16BFD82A18B9E CRC64;
MRFQLCYLLG LLSVTSLSHA ASNLICYYDS TSYLRQGLAK MHTHELDLAL QFCTHLVYGY
AGLKAGTLEL FSLNVDLDMF YYKEITALRQ KFPQLKILLS VGGDRDVDEA HPNKYVELLE
ANRTFQQNFI DSSMILVKRN GFDGLDLAFQ LPRNKPRKVH GSLGTYWKSF KKLFTGDFVV
DPLAEQHKSQ FTDLVGNLKN AFRSANLMLS LTVLPNVNST WYFDVPKLHP QFEYINLAAF
DFLTPVRNPE EADFTAPIFF QDEQNRLPHL NVEFQVNYWL QNNCPGQKLN LGIASYGRAW
KLSKGSGLSG APIVQETCGA APGGIQIQSA DGLLSWPEIC SKLSQNASAQ YRGEMAPLRK
VTDLTQKYGN YALRPADDNG DFGVWLSFDD PDFAGIKAAY AKGKGLGGVA IFDLSYDDFR
GLCTGQKFPI VRSIKYFMG