ID   APC13_XENTR             Reviewed;          74 AA.
AC   Q28IW8; Q0IJ25;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Anaphase-promoting complex subunit 13;
DE            Short=APC13;
DE   AltName: Full=Cyclosome subunit 13;
GN   Name=anapc13; ORFNames=TNeu008m03.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC       (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC       progression through mitosis and the G1 phase of the cell cycle. The
CC       APC/C complex acts by mediating ubiquitination and subsequent
CC       degradation of target proteins: it mainly mediates the formation of
CC       'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC       formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By
CC       similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: The APC/C is composed of at least 12 subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the APC13 family. {ECO:0000305}.
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DR   EMBL; CR760186; CAJ82693.1; -; mRNA.
DR   EMBL; BC121222; AAI21223.1; -; mRNA.
DR   RefSeq; NP_001017240.1; NM_001017240.2.
DR   RefSeq; XP_012823933.1; XM_012968479.2.
DR   RefSeq; XP_012823934.1; XM_012968480.2.
DR   AlphaFoldDB; Q28IW8; -.
DR   PaxDb; Q28IW8; -.
DR   GeneID; 549994; -.
DR   KEGG; xtr:549994; -.
DR   CTD; 549994; -.
DR   Xenbase; XB-GENE-958927; anapc13.1.
DR   eggNOG; ENOG502S4J1; Eukaryota.
DR   HOGENOM; CLU_199969_0_0_1; -.
DR   InParanoid; Q28IW8; -.
DR   OrthoDB; 1635284at2759; -.
DR   TreeFam; TF105448; -.
DR   Reactome; R-XTR-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.
DR   InterPro; IPR008401; Apc13.
DR   PANTHER; PTHR28672; PTHR28672; 1.
DR   Pfam; PF05839; Apc13p; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Mitosis; Nucleus; Reference proteome;
KW   Ubl conjugation pathway.
FT   CHAIN           1..74
FT                   /note="Anaphase-promoting complex subunit 13"
FT                   /id="PRO_0000253983"
FT   CONFLICT        70
FT                   /note="S -> P (in Ref. 2; AAI21223)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   74 AA;  8417 MW;  7A1D8F9CFE53EE3B CRC64;
     MDSEVLRDGR ILDLIDDAWR EDKLPYEDVT IPLNELPEPE QDNGGATESV KEQEMKWADL
     ALQYLHENIS SSGS