ID   APC15_BOVIN             Reviewed;         121 AA.
AC   Q3SZ31;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Anaphase-promoting complex subunit 15;
DE            Short=APC15;
GN   Name=ANAPC15;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Rumen;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC       (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC       progression through mitosis and the G1 phase of the cell cycle. In the
CC       complex, plays a role in the release of the mitotic checkpoint complex
CC       (MCC) from the APC/C: not required for APC/C activity itself, but
CC       promotes the turnover of CDC20 and MCC on the APC/C, thereby
CC       participating in the responsiveness of the spindle assembly checkpoint.
CC       Also required for degradation of CDC20 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The mammalian APC/C is composed at least of 14 distinct
CC       subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6,
CC       ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and
CC       ANAPC16 that assemble into a complex of at least 19 chains with a
CC       combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1
CC       and FBXO5. {ECO:0000250|UniProtKB:P60006}.
CC   -!- SIMILARITY: Belongs to the APC15 family. {ECO:0000305}.
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DR   EMBL; BC103197; AAI03198.1; -; mRNA.
DR   RefSeq; NP_001029415.1; NM_001034243.1.
DR   RefSeq; XP_010799290.1; XM_010800988.2.
DR   RefSeq; XP_010822824.1; XM_010824522.2.
DR   AlphaFoldDB; Q3SZ31; -.
DR   STRING; 9913.ENSBTAP00000003902; -.
DR   PaxDb; Q3SZ31; -.
DR   PRIDE; Q3SZ31; -.
DR   Ensembl; ENSBTAT00000003902; ENSBTAP00000003902; ENSBTAG00000002999.
DR   GeneID; 101905242; -.
DR   GeneID; 505356; -.
DR   KEGG; bta:101905242; -.
DR   KEGG; bta:505356; -.
DR   CTD; 25906; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002999; -.
DR   VGNC; VGNC:25882; ANAPC15.
DR   eggNOG; ENOG502RZUK; Eukaryota.
DR   GeneTree; ENSGT00390000000938; -.
DR   HOGENOM; CLU_142923_0_0_1; -.
DR   InParanoid; Q3SZ31; -.
DR   OMA; EGTDQDQ; -.
DR   OrthoDB; 1586519at2759; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000002999; Expressed in biceps femoris and 105 other tissues.
DR   ExpressionAtlas; Q3SZ31; baseline and differential.
DR   GO; GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0090266; P:regulation of mitotic cell cycle spindle assembly checkpoint; ISS:UniProtKB.
DR   InterPro; IPR026182; ANAPC15.
DR   PANTHER; PTHR22526; PTHR22526; 1.
DR   Pfam; PF15243; ANAPC15; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Mitosis; Reference proteome.
FT   CHAIN           1..121
FT                   /note="Anaphase-promoting complex subunit 15"
FT                   /id="PRO_0000084071"
FT   REGION          46..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..113
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   121 AA;  14281 MW;  2C8897C0DEB626F2 CRC64;
     MSTLFPSLFP RVTETLWFNL DRPCVEETEL QQQEQQHQAW LQSIAEKDNN LVPIGKPASE
     HYDDEEEEDE DDDEDSEEDS EDDEDMQDMD EMNDYNESPD DGEVNEVDME GNEQDQDQWM
     I