ID   APC15_DANRE             Reviewed;         121 AA.
AC   F1QY75; Q0P441;
DT   16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Anaphase-promoting complex subunit 15;
DE            Short=APC15;
GN   Name=anapc15; ORFNames=zgc:153425;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC       (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC       progression through mitosis and the G1 phase of the cell cycle.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The APC/C is composed of at least 12 subunits. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the APC15 family. {ECO:0000305}.
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DR   EMBL; CABZ01088540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01088541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC122287; AAI22288.1; -; mRNA.
DR   RefSeq; NP_001038915.1; NM_001045450.1.
DR   RefSeq; XP_017206505.1; XM_017351016.1.
DR   AlphaFoldDB; F1QY75; -.
DR   SMR; F1QY75; -.
DR   STRING; 7955.ENSDARP00000105664; -.
DR   PaxDb; F1QY75; -.
DR   Ensembl; ENSDART00000164983; ENSDARP00000139654; ENSDARG00000101285.
DR   Ensembl; ENSDART00000176289; ENSDARP00000143478; ENSDARG00000101285.
DR   GeneID; 751740; -.
DR   KEGG; dre:751740; -.
DR   CTD; 25906; -.
DR   ZFIN; ZDB-GENE-060825-43; anapc15.
DR   eggNOG; ENOG502RZUK; Eukaryota.
DR   GeneTree; ENSGT00390000000938; -.
DR   HOGENOM; CLU_142923_0_0_1; -.
DR   InParanoid; F1QY75; -.
DR   OMA; EGTDQDQ; -.
DR   OrthoDB; 1586519at2759; -.
DR   Reactome; R-DRE-141430; Inactivation of APC/C via direct inhibition of the APC/C complex.
DR   Reactome; R-DRE-174048; APC/C:Cdc20 mediated degradation of Cyclin B.
DR   Reactome; R-DRE-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR   Reactome; R-DRE-174154; APC/C:Cdc20 mediated degradation of Securin.
DR   Reactome; R-DRE-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR   Reactome; R-DRE-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR   Reactome; R-DRE-176407; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
DR   Reactome; R-DRE-176408; Regulation of APC/C activators between G1/S and early anaphase.
DR   Reactome; R-DRE-176412; Phosphorylation of the APC/C.
DR   Reactome; R-DRE-179409; APC-Cdc20 mediated degradation of Nek2A.
DR   Reactome; R-DRE-2467813; Separation of Sister Chromatids.
DR   Reactome; R-DRE-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR   Reactome; R-DRE-68867; Assembly of the pre-replicative complex.
DR   Reactome; R-DRE-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR   PRO; PR:F1QY75; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 15.
DR   Bgee; ENSDARG00000101285; Expressed in testis and 26 other tissues.
DR   ExpressionAtlas; F1QY75; baseline.
DR   GO; GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0090266; P:regulation of mitotic cell cycle spindle assembly checkpoint; ISS:UniProtKB.
DR   InterPro; IPR026182; ANAPC15.
DR   PANTHER; PTHR22526; PTHR22526; 1.
DR   Pfam; PF15243; ANAPC15; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Mitosis; Reference proteome.
FT   CHAIN           1..121
FT                   /note="Anaphase-promoting complex subunit 15"
FT                   /id="PRO_0000417539"
FT   REGION          52..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..113
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        19
FT                   /note="N -> D (in Ref. 2; AAI22288)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   121 AA;  14376 MW;  EACCE790F2391AA8 CRC64;
     MSALFPSLFP RVTESLWFNL DRPCVDEAEL NQQEQQHQTW LQSIVEKDNN LMPIGRPIFE
     TFDEEEEEDD EDEEDSEEDS EDDEDMQDMD DMNIYNEFPD DGEINEVDME GADQDQDQWM
     I