IDH4_ARATH
ID IDH4_ARATH Reviewed; 294 AA.
AC Q9LQK9; Q1PFP9;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Putative isocitrate dehydrogenase [NAD] subunit-like 4;
DE AltName: Full=IDH-IV;
DE AltName: Full=Isocitric dehydrogenase-like protein 4;
DE AltName: Full=NAD(+)-specific ICDH 4;
GN Name=IDH4; OrderedLocusNames=At1g32480; ORFNames=F5D14.26;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP GENE FAMILY.
RX AGRICOLA=IND43633651; DOI=10.1016/j.plantsci.2003.12.012;
RA Lin M., Behal R.H., Oliver D.J.;
RT "Characterization of a mutation in the IDH-II subunit of the NAD(+)-
RT dependent isocitrate dehydrogenase from Arabidopsis thaliana.";
RL Plant Sci. 166:983-988(2004).
CC -!- FUNCTION: Performs an essential role in the oxidative function of the
CC citric acid cycle. {ECO:0000250|UniProtKB:P93032}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9LQK9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9LQK9-2; Sequence=VSP_022292, VSP_022293;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to an intron retention.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000305}.
CC -!- CAUTION: Lacks the isocitrate binding site which is one of the
CC conserved features of the isocitrate dehydrogenase family.
CC {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AC007767; AAF81346.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31491.1; -; Genomic_DNA.
DR EMBL; DQ446314; ABE65678.1; -; mRNA.
DR PIR; B86450; B86450.
DR RefSeq; NP_174526.2; NM_102983.2. [Q9LQK9-2]
DR AlphaFoldDB; Q9LQK9; -.
DR SMR; Q9LQK9; -.
DR BioGRID; 25376; 1.
DR STRING; 3702.AT1G32480.1; -.
DR PaxDb; Q9LQK9; -.
DR PeptideAtlas; Q9LQK9; -.
DR PRIDE; Q9LQK9; -.
DR EnsemblPlants; AT1G32480.1; AT1G32480.1; AT1G32480. [Q9LQK9-2]
DR GeneID; 840142; -.
DR Gramene; AT1G32480.1; AT1G32480.1; AT1G32480. [Q9LQK9-2]
DR KEGG; ath:AT1G32480; -.
DR Araport; AT1G32480; -.
DR TAIR; locus:2033713; AT1G32480.
DR eggNOG; KOG0784; Eukaryota.
DR InParanoid; Q9LQK9; -.
DR OMA; NEIGINN; -.
DR OrthoDB; 868374at2759; -.
DR PhylomeDB; Q9LQK9; -.
DR BioCyc; ARA:AT1G32480-MON; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LQK9; differential.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IBA:GO_Central.
DR GO; GO:0006102; P:isocitrate metabolic process; IBA:GO_Central.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR Pfam; PF00180; Iso_dh; 2.
DR SMART; SM01329; Iso_dh; 1.
PE 5: Uncertain;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..294
FT /note="Putative isocitrate dehydrogenase [NAD] subunit-like
FT 4"
FT /id="PRO_0000271290"
FT VAR_SEQ 188..214
FT /note="ASRETRAIRRHSNSKSLWAIIANIASG -> GINNCCLQLVEKPERFDVIVT
FT PNLYGL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17147637"
FT /id="VSP_022292"
FT VAR_SEQ 215..294
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17147637"
FT /id="VSP_022293"
SQ SEQUENCE 294 AA; 32851 MW; 46575E963FAE9C6B CRC64;
MPRPVTVIDS NVTNAVHQVM DAMQAPVYFE TYIIKGKNMN HLTWEVVDSI RKNKVCLNGR
VNNSLCGGAR KELDLFASLV DCFNLNGQPS RHENVDIVVI RENTEGEYAG REHEVVPGVI
ESFQVTMTKF WSDRIAKYAF EYAHFSKRKK VTAVHNNGKY EKLADAFFLE SCQEVAKMYP
NITYNEIASR ETRAIRRHSN SKSLWAIIAN IASGVAGGSF GDDYAIFEQV GSVGNHKNPV
ALLFSSVMML RHLLLPLFAD RLKTAVTRVI SEGKCGNSNT TTQEVVDSVI ANLD
