APC15_SCHPO
ID APC15_SCHPO Reviewed; 136 AA.
AC O94688;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Anaphase-promoting complex subunit 15;
DE AltName: Full=20S cyclosome/APC complex protein apc15;
GN Name=apc15; ORFNames=SPBC83.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, AND SUBUNIT.
RX PubMed=12477395; DOI=10.1016/s0960-9822(02)01331-3;
RA Yoon H.-J., Feoktistova A., Wolfe B.A., Jennings J.L., Link A.J.,
RA Gould K.L.;
RT "Proteomics analysis identifies new components of the fission and budding
RT yeast anaphase-promoting complexes.";
RL Curr. Biol. 12:2048-2054(2002).
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex
CC that controls progression through mitosis and the G1 phase of the cell
CC cycle. The APC/C is thought to confer substrate specificity and, in the
CC presence of ubiquitin-conjugating E2 enzymes, it catalyzes the
CC formation of protein-ubiquitin conjugates that are subsequently
CC degraded by the 26S proteasome. {ECO:0000269|PubMed:12477395}.
CC -!- SUBUNIT: The APC/C is composed of at least 13 subunits: apc1, apc2,
CC nuc2, apc4, apc5, cut9, apc8, apc10, apc11, hcn1, apc13, apc14 and
CC apc15. {ECO:0000269|PubMed:12477395}.
CC -!- INTERACTION:
CC O94688; O74358: apc13; NbExp=3; IntAct=EBI-1251604, EBI-1251583;
CC O94688; O42659: apc14; NbExp=2; IntAct=EBI-1251604, EBI-1251592;
CC O94688; P41889: cut9; NbExp=2; IntAct=EBI-1251604, EBI-1160859;
CC -!- SIMILARITY: Belongs to the APC15 family. {ECO:0000305}.
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DR EMBL; CU329671; CAB36866.1; -; Genomic_DNA.
DR PIR; T40693; T40693.
DR RefSeq; NP_595636.1; NM_001021530.2.
DR AlphaFoldDB; O94688; -.
DR BioGRID; 277180; 7.
DR ComplexPortal; CPX-763; Anaphase-Promoting Complex variant 1.
DR ComplexPortal; CPX-764; Anaphase-Promoting Complex variant 2.
DR ComplexPortal; CPX-765; Anaphase-Promoting Complex variant 3.
DR ComplexPortal; CPX-766; Anaphase-Promoting Complex variant 4.
DR IntAct; O94688; 4.
DR STRING; 4896.SPBC83.04.1; -.
DR MaxQB; O94688; -.
DR PaxDb; O94688; -.
DR EnsemblFungi; SPBC83.04.1; SPBC83.04.1:pep; SPBC83.04.
DR GeneID; 2540655; -.
DR KEGG; spo:SPBC83.04; -.
DR PomBase; SPBC83.04; apc15.
DR VEuPathDB; FungiDB:SPBC83.04; -.
DR eggNOG; ENOG502SGKU; Eukaryota.
DR HOGENOM; CLU_1876627_0_0_1; -.
DR InParanoid; O94688; -.
DR OMA; TAHELWY; -.
DR PRO; PR:O94688; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005680; C:anaphase-promoting complex; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; EXP:PomBase.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IMP:PomBase.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:1905785; P:negative regulation of anaphase-promoting complex-dependent catabolic process; IMP:PomBase.
DR GO; GO:0030071; P:regulation of mitotic metaphase/anaphase transition; IEA:InterPro.
DR InterPro; IPR008402; APC_su15/mnd2.
DR Pfam; PF05841; Apc15p; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Mitosis; Reference proteome;
KW Ubl conjugation pathway.
FT CHAIN 1..136
FT /note="Anaphase-promoting complex subunit 15"
FT /id="PRO_0000237685"
FT REGION 57..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..117
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 136 AA; 15786 MW; 086B97F02A6F0C8B CRC64;
MSFMSLMANT AHQLWYPTSF PSMKELEKEE VRLETQELAI KQFGFRTIRP IGLNRSMQEQ
LDLEEQEREE ANQDTELDEE ELGSGSFPEE GEMDDMDGDN EEVEDHDIEE VDLDADITNA
DASEFYEDIS EYGFQN
