ID   APC15_XENTR             Reviewed;         120 AA.
AC   A9JSB3; F6YES5; F7C0B3;
DT   16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Anaphase-promoting complex subunit 15;
DE            Short=APC15;
GN   Name=anapc15;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula, and Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC       (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC       progression through mitosis and the G1 phase of the cell cycle.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The APC/C is composed of at least 12 subunits. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the APC15 family. {ECO:0000305}.
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DR   EMBL; AAMC01113660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC155989; AAI55990.1; -; mRNA.
DR   EMBL; BC171286; AAI71286.1; -; mRNA.
DR   EMBL; BC171288; AAI71288.1; -; mRNA.
DR   RefSeq; NP_001107320.1; NM_001113848.1.
DR   RefSeq; XP_012819698.1; XM_012964244.2.
DR   AlphaFoldDB; A9JSB3; -.
DR   SMR; A9JSB3; -.
DR   Ensembl; ENSXETT00000051458; ENSXETP00000051458; ENSXETG00000023871.
DR   GeneID; 100135123; -.
DR   KEGG; xtr:100135123; -.
DR   CTD; 25906; -.
DR   Xenbase; XB-GENE-5892495; anapc15.
DR   HOGENOM; CLU_142923_0_0_1; -.
DR   InParanoid; A9JSB3; -.
DR   OMA; IDMEVSY; -.
DR   OrthoDB; 1586519at2759; -.
DR   PhylomeDB; A9JSB3; -.
DR   Reactome; R-XTR-141430; Inactivation of APC/C via direct inhibition of the APC/C complex.
DR   Reactome; R-XTR-174048; APC/C:Cdc20 mediated degradation of Cyclin B.
DR   Reactome; R-XTR-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR   Reactome; R-XTR-174154; APC/C:Cdc20 mediated degradation of Securin.
DR   Reactome; R-XTR-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR   Reactome; R-XTR-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR   Reactome; R-XTR-176407; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
DR   Reactome; R-XTR-176408; Regulation of APC/C activators between G1/S and early anaphase.
DR   Reactome; R-XTR-176409; APC/C:Cdc20 mediated degradation of mitotic proteins.
DR   Reactome; R-XTR-176412; Phosphorylation of the APC/C.
DR   Reactome; R-XTR-179409; APC-Cdc20 mediated degradation of Nek2A.
DR   Reactome; R-XTR-2467813; Separation of Sister Chromatids.
DR   Reactome; R-XTR-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR   Reactome; R-XTR-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000023871; Expressed in testis and 12 other tissues.
DR   GO; GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0090266; P:regulation of mitotic cell cycle spindle assembly checkpoint; ISS:UniProtKB.
DR   InterPro; IPR026182; ANAPC15.
DR   PANTHER; PTHR22526; PTHR22526; 1.
DR   Pfam; PF15243; ANAPC15; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Mitosis; Reference proteome.
FT   CHAIN           1..120
FT                   /note="Anaphase-promoting complex subunit 15"
FT                   /id="PRO_0000417542"
FT   REGION          44..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..112
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   120 AA;  13969 MW;  7CAD0E3E603EE704 CRC64;
     MSTLFPSLFP QVTDSLWFNL DRPCVDENEL QQQEQQHQAW LQSIAEKDNG LVPIGKPASE
     PYDEEEEEDD EDDEDSEEDS EDDEDMQDMD EMNDYNESPD DGEIEADMEG AEQDQDQWMI