ID   APC16_BOVIN             Reviewed;         110 AA.
AC   Q58DR0; Q1RMH7;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Anaphase-promoting complex subunit 16;
DE            Short=APC16;
DE   AltName: Full=Cyclosome subunit 16;
GN   Name=ANAPC16;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC       (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC       progression through mitosis and the G1 phase of the cell cycle. The
CC       APC/C complex acts by mediating ubiquitination and subsequent
CC       degradation of target proteins: it mainly mediates the formation of
CC       'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC       formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By
CC       similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: The mammalian APC/C is composed at least of 14 distinct
CC       subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6,
CC       ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and
CC       ANAPC16 that assemble into a complex of at least 19 chains with a
CC       combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1
CC       and FBXO5. ANAPC16 associates with the rest of the complex
CC       independently of ANAPC2 and ANAPC11. {ECO:0000250|UniProtKB:Q96DE5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96DE5}. Nucleus
CC       {ECO:0000250|UniProtKB:Q96DE5}. Chromosome, centromere, kinetochore
CC       {ECO:0000250|UniProtKB:Q96DE5}.
CC   -!- SIMILARITY: Belongs to the APC16 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BT021537; AAX46384.1; -; mRNA.
DR   EMBL; BC114889; AAI14890.1; -; mRNA.
DR   RefSeq; NP_001014960.1; NM_001014960.1.
DR   RefSeq; XP_005226503.1; XM_005226446.3.
DR   RefSeq; XP_005226504.1; XM_005226447.2.
DR   RefSeq; XP_005226505.1; XM_005226448.3.
DR   AlphaFoldDB; Q58DR0; -.
DR   SMR; Q58DR0; -.
DR   STRING; 9913.ENSBTAP00000000186; -.
DR   PaxDb; Q58DR0; -.
DR   Ensembl; ENSBTAT00000000186; ENSBTAP00000000186; ENSBTAG00000000162.
DR   GeneID; 540089; -.
DR   KEGG; bta:540089; -.
DR   CTD; 119504; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000162; -.
DR   VGNC; VGNC:25883; ANAPC16.
DR   eggNOG; ENOG502RZ50; Eukaryota.
DR   GeneTree; ENSGT00390000018109; -.
DR   HOGENOM; CLU_153312_0_0_1; -.
DR   InParanoid; Q58DR0; -.
DR   OMA; XGSERFL; -.
DR   OrthoDB; 1642213at2759; -.
DR   TreeFam; TF332754; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Chromosome 28.
DR   Bgee; ENSBTAG00000000162; Expressed in biceps femoris and 105 other tissues.
DR   GO; GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0000776; C:kinetochore; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   InterPro; IPR029641; APC16.
DR   PANTHER; PTHR31564; PTHR31564; 1.
DR   Pfam; PF17256; ANAPC16; 1.
PE   3: Inferred from homology;
KW   Acetylation; Cell cycle; Cell division; Centromere; Chromosome; Cytoplasm;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome; Ubl conjugation pathway.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q96DE5"
FT   CHAIN           2..110
FT                   /note="Anaphase-promoting complex subunit 16"
FT                   /id="PRO_0000089815"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96DE5"
SQ   SEQUENCE   110 AA;  11637 MW;  EEE38A86B1ACCF0A CRC64;
     MAASSSSSSA GGVSGSSVAG SGFSVSDLAP PRKALFTYPK GAGEMLEDGS ERFLCESVFS
     YQVASTLKQV KHDQQVARME KLAGLVEELE ADEWRFKPIE QLLGFTPSSG