ID   IDI1_CLABR              Reviewed;         287 AA.
AC   Q39472;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Isopentenyl-diphosphate Delta-isomerase I;
DE            EC=5.3.3.2;
DE   AltName: Full=Isopentenyl pyrophosphate isomerase I;
DE            Short=IPP isomerase I;
GN   Name=IPI1;
OS   Clarkia breweri (Fairy fans) (Eucharidium breweri).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Myrtales; Onagraceae; Onagroideae; Onagreae; Clarkia.
OX   NCBI_TaxID=36903;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7610186; DOI=10.1104/pp.108.2.855;
RA   Blanc V.M., Pichersky E.;
RT   "Nucleotide sequence of a Clarkia breweri cDNA clone of Ipi1, a gene
RT   encoding isopentenyl pyrophosphate isomerase.";
RL   Plant Physiol. 108:855-856(1995).
CC   -!- FUNCTION: Catalyzes the 1,3-allylic rearrangement of the homoallylic
CC       substrate isopentenyl (IPP) to its highly electrophilic allylic isomer,
CC       dimethylallyl diphosphate (DMAPP). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=isopentenyl diphosphate = dimethylallyl diphosphate;
CC         Xref=Rhea:RHEA:23284, ChEBI:CHEBI:57623, ChEBI:CHEBI:128769;
CC         EC=5.3.3.2;
CC   -!- PATHWAY: Isoprenoid biosynthesis; dimethylallyl diphosphate
CC       biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate:
CC       step 1/1.
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; chlorophyll
CC       biosynthesis.
CC   -!- SIMILARITY: Belongs to the IPP isomerase type 1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA57947.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X82627; CAA57947.1; ALT_INIT; mRNA.
DR   PIR; S49588; S49588.
DR   AlphaFoldDB; Q39472; -.
DR   SMR; Q39472; -.
DR   UniPathway; UPA00059; UER00104.
DR   UniPathway; UPA00668; -.
DR   GO; GO:0004452; F:isopentenyl-diphosphate delta-isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0050992; P:dimethylallyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0015979; P:photosynthesis; IEA:UniProtKB-KW.
DR   CDD; cd02885; IPP_Isomerase; 1.
DR   InterPro; IPR011876; IsopentenylPP_isomerase_typ1.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   InterPro; IPR000086; NUDIX_hydrolase_dom.
DR   Pfam; PF00293; NUDIX; 1.
DR   SUPFAM; SSF55811; SSF55811; 1.
DR   TIGRFAMs; TIGR02150; IPP_isom_1; 1.
DR   PROSITE; PS51462; NUDIX; 1.
PE   2: Evidence at transcript level;
KW   Chlorophyll biosynthesis; Isomerase; Isoprene biosynthesis; Photosynthesis.
FT   CHAIN           1..287
FT                   /note="Isopentenyl-diphosphate Delta-isomerase I"
FT                   /id="PRO_0000205236"
FT   DOMAIN          105..257
FT                   /note="Nudix hydrolase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00794"
FT   ACT_SITE        142
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        207
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   287 AA;  32956 MW;  204E729D07382AA7 CRC64;
     MSSSMLNFTA SRIVSLPLLS SPPSRVHLPL CFFSPISLTQ RFSAKLTFSS QATTMGEVVD
     AGMDAVQRRL MFEDECILVD ENDKVVGHES KYNCHLMEKI ESENLLHRAF SVFLFNSKYE
     LLLQQRSATK VTFPLVWTNT CCSHPLYRES ELIDENCLGV RNAAQRKLLD ELGIPAEDLP
     VDQFIPLSRI LYKAPSDGKW GEHELDYLLF IIRDVNLDPN PDEVAEVKYM NRDDLKELLR
     KADAEEEGVK LSPWFRLVVD NFLFKWWDHV EKGSLKDAAD MKTIHKL