ID   APC16_PONAB             Reviewed;         110 AA.
AC   Q5REH8;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Anaphase-promoting complex subunit 16;
DE            Short=APC16;
DE   AltName: Full=Cyclosome subunit 16;
GN   Name=ANAPC16;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC       (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC       progression through mitosis and the G1 phase of the cell cycle. The
CC       APC/C complex acts by mediating ubiquitination and subsequent
CC       degradation of target proteins: it mainly mediates the formation of
CC       'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC       formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By
CC       similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: The mammalian APC/C is composed at least of 14 distinct
CC       subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6,
CC       ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and
CC       ANAPC16 that assemble into a complex of at least 19 chains with a
CC       combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1
CC       and FBXO5. ANAPC16 associates with the rest of the complex
CC       independently of ANAPC2 and ANAPC11. {ECO:0000250|UniProtKB:Q96DE5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96DE5}. Nucleus
CC       {ECO:0000250|UniProtKB:Q96DE5}. Chromosome, centromere, kinetochore
CC       {ECO:0000250|UniProtKB:Q96DE5}.
CC   -!- SIMILARITY: Belongs to the APC16 family. {ECO:0000305}.
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DR   EMBL; CR857550; CAH89829.1; -; mRNA.
DR   RefSeq; NP_001124848.1; NM_001131376.1.
DR   RefSeq; XP_009243772.1; XM_009245497.1.
DR   AlphaFoldDB; Q5REH8; -.
DR   SMR; Q5REH8; -.
DR   STRING; 9601.ENSPPYP00000023872; -.
DR   Ensembl; ENSPPYT00000002827; ENSPPYP00000002734; ENSPPYG00000002355.
DR   GeneID; 100171709; -.
DR   KEGG; pon:100171709; -.
DR   CTD; 119504; -.
DR   eggNOG; ENOG502RZ50; Eukaryota.
DR   GeneTree; ENSGT00390000018109; -.
DR   HOGENOM; CLU_153312_0_0_1; -.
DR   InParanoid; Q5REH8; -.
DR   OMA; XGSERFL; -.
DR   OrthoDB; 1642213at2759; -.
DR   TreeFam; TF332754; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000001595; Chromosome 10.
DR   GO; GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0000776; C:kinetochore; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   InterPro; IPR029641; APC16.
DR   PANTHER; PTHR31564; PTHR31564; 1.
DR   Pfam; PF17256; ANAPC16; 1.
PE   3: Inferred from homology;
KW   Acetylation; Cell cycle; Cell division; Centromere; Chromosome; Cytoplasm;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome; Ubl conjugation pathway.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q96DE5"
FT   CHAIN           2..110
FT                   /note="Anaphase-promoting complex subunit 16"
FT                   /id="PRO_0000089818"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96DE5"
SQ   SEQUENCE   110 AA;  11667 MW;  F348FA92F4B89E4F CRC64;
     MAASSSSSSA GGVSGSSVTG SGFSVSDLAP PRKALFTYPK GAGEMLEDGS ERFLCESVFS
     YQVASTLKQV KHDQQVARME KLAGLVEELE ADEWRFKPIE QLLGFTPSSG