ID   APC16_XENLA             Reviewed;         112 AA.
AC   Q6GQ63;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Anaphase-promoting complex subunit 16;
DE            Short=APC16;
DE   AltName: Full=Cyclosome subunit 16;
GN   Name=anapc16;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC       (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC       progression through mitosis and the G1 phase of the cell cycle. The
CC       APC/C complex acts by mediating ubiquitination and subsequent
CC       degradation of target proteins: it mainly mediates the formation of
CC       'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC       formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By
CC       similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: The APC/C is composed of at least 12 subunits. ANAPC16
CC       associates with the rest of the complex independently of ANAPC2 and
CC       ANAPC11 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96DE5}. Nucleus
CC       {ECO:0000250|UniProtKB:Q96DE5}. Chromosome, centromere, kinetochore
CC       {ECO:0000250|UniProtKB:Q96DE5}.
CC   -!- SIMILARITY: Belongs to the APC16 family. {ECO:0000305}.
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DR   EMBL; BC072885; AAH72885.1; -; mRNA.
DR   RefSeq; NP_001085523.1; NM_001092054.1.
DR   AlphaFoldDB; Q6GQ63; -.
DR   SMR; Q6GQ63; -.
DR   DNASU; 443949; -.
DR   GeneID; 443949; -.
DR   KEGG; xla:443949; -.
DR   CTD; 443949; -.
DR   Xenbase; XB-GENE-953460; anapc16.L.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 443949; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000776; C:kinetochore; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   InterPro; IPR029641; APC16.
DR   PANTHER; PTHR31564; PTHR31564; 1.
DR   Pfam; PF17256; ANAPC16; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Cytoplasm; Kinetochore;
KW   Mitosis; Nucleus; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..112
FT                   /note="Anaphase-promoting complex subunit 16"
FT                   /id="PRO_0000294085"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   112 AA;  11777 MW;  BB55122CD1BA70FD CRC64;
     MAASSSSSSA GGVSGSSVTG SGLSVSDLAP PRKALFTCPK AAGEMLEDGS ERFLCESVFS
     YQVASTLKQV KHDQQVSRME KLAGLVEELE ADEWRYTPIE QLLGFTPSSG GK