APC16_XENTR
ID APC16_XENTR Reviewed; 113 AA.
AC Q6DJQ9; Q28DH5;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Anaphase-promoting complex subunit 16;
DE Short=APC16;
DE AltName: Full=Cyclosome subunit 16;
GN Name=anapc16; ORFNames=TEgg142f17.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC progression through mitosis and the G1 phase of the cell cycle. The
CC APC/C complex acts by mediating ubiquitination and subsequent
CC degradation of target proteins: it mainly mediates the formation of
CC 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By
CC similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: The APC/C is composed of at least 12 subunits. ANAPC16
CC associates with the rest of the complex independently of ANAPC2 and
CC ANAPC11 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96DE5}. Nucleus
CC {ECO:0000250|UniProtKB:Q96DE5}. Chromosome, centromere, kinetochore
CC {ECO:0000250|UniProtKB:Q96DE5}.
CC -!- SIMILARITY: Belongs to the APC16 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAJ81371.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CR855511; CAJ81371.1; ALT_INIT; mRNA.
DR EMBL; BC075115; AAH75115.1; -; mRNA.
DR RefSeq; NP_001004873.1; NM_001004873.1.
DR RefSeq; XP_012821816.1; XM_012966362.2.
DR RefSeq; XP_012821817.1; XM_012966363.2.
DR AlphaFoldDB; Q6DJQ9; -.
DR SMR; Q6DJQ9; -.
DR PaxDb; Q6DJQ9; -.
DR DNASU; 448194; -.
DR Ensembl; ENSXETT00000013527; ENSXETP00000013527; ENSXETG00000006150.
DR GeneID; 448194; -.
DR KEGG; xtr:448194; -.
DR CTD; 119504; -.
DR Xenbase; XB-GENE-953456; anapc16.
DR eggNOG; ENOG502RZ50; Eukaryota.
DR HOGENOM; CLU_153312_0_0_1; -.
DR InParanoid; Q6DJQ9; -.
DR OMA; XGSERFL; -.
DR OrthoDB; 1642213at2759; -.
DR TreeFam; TF332754; -.
DR Reactome; R-XTR-141430; Inactivation of APC/C via direct inhibition of the APC/C complex.
DR Reactome; R-XTR-174048; APC/C:Cdc20 mediated degradation of Cyclin B.
DR Reactome; R-XTR-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR Reactome; R-XTR-174154; APC/C:Cdc20 mediated degradation of Securin.
DR Reactome; R-XTR-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR Reactome; R-XTR-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR Reactome; R-XTR-176407; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
DR Reactome; R-XTR-176408; Regulation of APC/C activators between G1/S and early anaphase.
DR Reactome; R-XTR-176409; APC/C:Cdc20 mediated degradation of mitotic proteins.
DR Reactome; R-XTR-176412; Phosphorylation of the APC/C.
DR Reactome; R-XTR-179409; APC-Cdc20 mediated degradation of Nek2A.
DR Reactome; R-XTR-2467813; Separation of Sister Chromatids.
DR Reactome; R-XTR-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR Reactome; R-XTR-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000008143; Chromosome 7.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000006150; Expressed in ovary and 14 other tissues.
DR ExpressionAtlas; Q6DJQ9; differential.
DR GO; GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0000776; C:kinetochore; ISS:UniProtKB.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR InterPro; IPR029641; APC16.
DR PANTHER; PTHR31564; PTHR31564; 1.
DR Pfam; PF17256; ANAPC16; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Centromere; Chromosome; Cytoplasm; Kinetochore;
KW Mitosis; Nucleus; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..113
FT /note="Anaphase-promoting complex subunit 16"
FT /id="PRO_0000294086"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 73
FT /note="H -> HGLIFS (in Ref. 1; CAJ81371)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 113 AA; 11882 MW; 0D1E52604E5AD40C CRC64;
MAASSSSSSA GGVSGSSVTG SGFSVSDLAP PRKALFTCPK AAGEMLEADG SERFLCESVF
SYQVASTLKQ VKHDQQVSRM EKLAGLVEEL EADEWRYTPI EQLLGFTPSS GGK
