ID   APC1_ARATH              Reviewed;        1678 AA.
AC   Q9FFF9;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Anaphase-promoting complex subunit 1;
DE   AltName: Full=Cyclosome subunit 1;
DE   AltName: Full=Protein EMBRYO DEFECTIVE 2771;
GN   Name=APC1; Synonyms=EMB2771; OrderedLocusNames=At5g05560;
GN   ORFNames=MOP10.10;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9330910; DOI=10.1093/dnares/4.3.215;
RA   Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M.,
RA   Miyajima N., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence
RT   features of the 1.6 Mb regions covered by twenty physically assigned P1
RT   clones.";
RL   DNA Res. 4:215-230(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC       (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex
CC       that controls progression through mitosis and the G1 phase of the cell
CC       cycle. The APC/C complex controls several key steps in the cell cycle
CC       by mediating ubiquitination and subsequent degradation of target
CC       proteins such as cyclins. The APC/C complex is required for the female
CC       gametophyte development and is involved in several aspect of
CC       development by controlling cell division and cell elongation. Involved
CC       in the control of endoreduplication (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: The APC/C is composed of at least 10 subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the APC1 family. {ECO:0000305}.
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DR   EMBL; AB005241; BAB11545.1; -; Genomic_DNA.
DR   EMBL; CP002688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q9FFF9; -.
DR   SMR; Q9FFF9; -.
DR   BioGRID; 15718; 13.
DR   IntAct; Q9FFF9; 13.
DR   STRING; 3702.AT5G05560.1; -.
DR   PaxDb; Q9FFF9; -.
DR   PeptideAtlas; Q9FFF9; -.
DR   PRIDE; Q9FFF9; -.
DR   Araport; AT5G05560; -.
DR   TAIR; locus:2169657; AT5G05560.
DR   eggNOG; KOG1858; Eukaryota.
DR   HOGENOM; CLU_001202_1_0_1; -.
DR   InParanoid; Q9FFF9; -.
DR   PhylomeDB; Q9FFF9; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q9FFF9; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FFF9; baseline and differential.
DR   Genevisible; Q9FFF9; AT.
DR   GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR   GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR   GO; GO:0010252; P:auxin homeostasis; IMP:TAIR.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.
DR   GO; GO:0009553; P:embryo sac development; IMP:TAIR.
DR   GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0048481; P:plant ovule development; IMP:TAIR.
DR   GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR024990; Apc1.
DR   InterPro; IPR011989; ARM-like.
DR   PANTHER; PTHR12827; PTHR12827; 3.
DR   Pfam; PF12859; ANAPC1; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Mitosis; Nucleus; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..1678
FT                   /note="Anaphase-promoting complex subunit 1"
FT                   /id="PRO_0000396837"
FT   REPEAT          1089..1116
FT                   /note="PC 1"
FT   REPEAT          1156..1194
FT                   /note="PC 2"
FT   REPEAT          1256..1293
FT                   /note="PC 3"
FT   REPEAT          1320..1354
FT                   /note="PC 4"
SQ   SEQUENCE   1678 AA;  186276 MW;  BBE887FCAE27CA3B CRC64;
     MPPGVRQLTV LGKFKPFGLI AEATDGKSPD DSYQYFLFDP ELTGERDDAD GNDANFSRQR
     EHELFIRDNC NVRKGYALVE ANFIGYWYNA CWSNLGRGTE AFLCVLQIAC LTIYNTSGEV
     VSVPLMRTVK SIWPLPCGLL LEQAGEVNPP SHVPFSPVSP ILGSREMLRQ RKEVGNSSPQ
     NFHSPVAHDL ISKRDMPCMS SHLILRDPLE EPGPTYVEER GKLTIMKDYD ERTIWTSDRL
     PLMTSYNKGK MQHSVWAAEF IESNLEASAS CSSGIVPDAV LSKRVSFRRI WQAKGAKKAA
     SKVFLATDNS VPVICFLILE QKKLLSVGLQ TVEINNEILF DVKPDISWSV SAIAAAPVVV
     TRSQVKIGLL PHLDIIVLSP ENDLFLYSGK QCLCRYVLPS WLGESIGSGD GESAKTDSGF
     RNLKITGLSD AVLGSINLSV NHSQIFRCAL TGKPSSSLAN DCIAAIAEGL RSDLYSLFLS
     LLWGDGHSDL QGSSIHFEWE ALCNIFLEIC QKPTVVHRKQ PKTASESSWE FLLISKFHKT
     YSRFHNGITS INRLDLEGIV PFDSKICSEE TLGSSCELMV QSLDCLHAVY ESLKMDNLRK
     QDLHHLAVLL CNIAKFLDEK CYLDYYIRDF PRLSTTIGAC TTLSSSRKPP NLFRWLENCL
     RRGCLSTNFD DLPDLIRRDG CSIVSWARKV VSFYSVLFGD KPEGRTLSSG VPCNIAPGSY
     SCNEELTILA MAGERFGLHQ LDLLPSGVSL PLRHALDSCR ESPPADWPAI AYVLLGREDM
     ALSVFRNFSS SKEFEMQSNT SLISMSIPYM LHLHPVIVPS SESIGLENTK IEDTNSVDGS
     VIDGMEHIFN SYTQLRYGRD LRLNEVRRLL CSARPVVVQT AANPTISDQE QQQAFTVPKL
     VLAGRLPSQQ NAIVNLDPNI RNIQELKTWP EFHNAVAAGL RLAPLQGKVS RTWIRYNKPG
     EPNAVHAGLL FGLGLQGYLH VLNLSDIYQY FTQDHESTTV GLMLGLAASY RGTMQPDIAK
     ALFFHVPARY QASYTEFEIP TLLQSAALVS VGMLFEGSAH QQTMQLLLGE IGRRSAGDNV
     LEREGYAVSA GFSLGLVALG RGGDALGSMD SLVNRLLLYL GAKEERSILV PSLEDHRSAA
     QITDGSTSNV DITAPGAIIA LTLMYLKTES EVIFSKLSIP QTHYDLECVR PDFIMLRVIA
     RNLIMWSRIC PTCDWIQSQV PEVVKNGISQ LRDDMDNMYE VDVEALVQAY VNIVAGACIS
     LGLRFAGTRD GNARDLLNSY ALYLLNEIKP LSATPGNAFP RGISKFVDRG TLEMCLYLII
     ISLSVVMAGS GDLQVFRLLR FLRSRNSADG HANYGTQMAV SLATGFLFLG GGMRTFSTNN
     GSLAMLLITL YPRLPSGPND NRCHLQAFRH LYVLATEARW LQTIDVDSGL PVYAPLEVTV
     KETKLYSETK FCEITPCILP ERAILKRICV CGPRYWPQQI ELVFGLRTLG ESNLIANSHR
     ELDSDSVDHL VSTFSSDPSL IAFAQLCCDK SWNNSFDFLI LDLILWSQVA LAYNEAVSTG
     RLASSGGFVQ SIFLASLRKR CEEVLNCSTE LKINLRNYLT SEAWPYDKNS KLQKDIIILS
     WYLKWFNVPS PSIIKAAVEK IKSKSKNSTS AIPLLRLLLP NTHISVIGEI DRVFFPSN