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APC1_CAEEL
ID   APC1_CAEEL              Reviewed;        1505 AA.
AC   O18191;
DT   20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 3.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Anaphase-promoting complex subunit 1 {ECO:0000250|UniProtKB:Q9H1A4};
DE            Short=APC1 {ECO:0000250|UniProtKB:Q9H1A4};
DE   AltName: Full=Metaphase-to-anaphase transition protein 2 {ECO:0000312|WormBase:W10C6.1};
GN   Name=mat-2 {ECO:0000312|WormBase:W10C6.1};
GN   Synonyms=apc-1 {ECO:0000312|WormBase:W10C6.1},
GN   evl-22 {ECO:0000312|WormBase:W10C6.1},
GN   pod-3 {ECO:0000312|WormBase:W10C6.1};
GN   ORFNames=W10C6.1 {ECO:0000312|WormBase:W10C6.1};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=11134076; DOI=10.1083/jcb.151.7.1469;
RA   Golden A., Sadler P.L., Wallenfang M.R., Schumacher J.M., Hamill D.R.,
RA   Bates G., Bowerman B., Seydoux G., Shakes D.C.;
RT   "Metaphase to anaphase (mat) transition-defective mutants in Caenorhabditis
RT   elegans.";
RL   J. Cell Biol. 151:1469-1482(2000).
RN   [3] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=11832245; DOI=10.1016/s1534-5807(02)00114-4;
RA   Rappleye C.A., Tagawa A., Lyczak R., Bowerman B., Aroian R.V.;
RT   "The anaphase-promoting complex and separin are required for embryonic
RT   anterior-posterior axis formation.";
RL   Dev. Cell 2:195-206(2002).
RN   [4] {ECO:0000305}
RP   FUNCTION, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF GLY-333; LEU-411;
RP   SER-828; PHE-975; MET-1196; ALA-1197 AND ARG-1297.
RX   PubMed=11861581; DOI=10.1093/genetics/160.2.805;
RA   Davis E.S., Wille L., Chestnut B.A., Sadler P.L., Shakes D.C., Golden A.;
RT   "Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex
RT   are required for chromosome segregation during meiosis I.";
RL   Genetics 160:805-813(2002).
RN   [5] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=15556870; DOI=10.1016/j.cub.2004.11.010;
RA   Juo P., Kaplan J.M.;
RT   "The anaphase-promoting complex regulates the abundance of GLR-1 glutamate
RT   receptors in the ventral nerve cord of C. elegans.";
RL   Curr. Biol. 14:2057-2062(2004).
RN   [6] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=24321454; DOI=10.1016/j.mcn.2013.12.001;
RA   Kowalski J.R., Dube H., Touroutine D., Rush K.M., Goodwin P.R., Carozza M.,
RA   Didier Z., Francis M.M., Juo P.;
RT   "The anaphase-promoting complex (APC) ubiquitin ligase regulates GABA
RT   transmission at the C. elegans neuromuscular junction.";
RL   Mol. Cell. Neurosci. 58:62-75(2014).
CC   -!- FUNCTION: Probable component of the anaphase promoting
CC       complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase
CC       that controls progression through mitosis and the G1 phase of the cell
CC       cycle (PubMed:11861581). The APC/C complex acts by mediating
CC       ubiquitination and subsequent degradation of target proteins
CC       (PubMed:11861581). Developmental role in early embryogenesis and the
CC       metaphase to anaphase transition in oocyte and spermatocyte meiosis and
CC       mitosis in germ cells (PubMed:11134076, PubMed:11861581). Required for
CC       embryonic anterior-posterior axis formation (PubMed:11832245). Plays a
CC       role in regulating the abundance of glr-1 receptors in postmitotic
CC       neurons, which may in turn control animal locomotion (PubMed:15556870).
CC       Involved in regulating GABA neurotransmitter release at neuromuscular
CC       junctions in GABA motor neurons (PubMed:24321454).
CC       {ECO:0000269|PubMed:11134076, ECO:0000269|PubMed:11832245,
CC       ECO:0000269|PubMed:11861581, ECO:0000269|PubMed:15556870,
CC       ECO:0000269|PubMed:24321454}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305}.
CC   -!- SUBUNIT: The APC/C complex is probably composed of at least 12
CC       subunits: apc-2, apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1,
CC       mat-2, mat-3, such-1 and gfi-3. {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in defective
CC       metaphase to anaphase transition (Mat phenotype) and embryos that
CC       arrest at the one-cell stage. {ECO:0000269|PubMed:11861581}.
CC   -!- SIMILARITY: Belongs to the APC1 family. {ECO:0000305}.
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DR   EMBL; Z99269; CAB16467.2; -; Genomic_DNA.
DR   RefSeq; NP_496383.2; NM_063982.3.
DR   AlphaFoldDB; O18191; -.
DR   SMR; O18191; -.
DR   ComplexPortal; CPX-3382; Anaphase Promoting Complex/Cyclosome.
DR   DIP; DIP-27230N; -.
DR   IntAct; O18191; 3.
DR   STRING; 6239.W10C6.1; -.
DR   EPD; O18191; -.
DR   PaxDb; O18191; -.
DR   PeptideAtlas; O18191; -.
DR   EnsemblMetazoa; W10C6.1.1; W10C6.1.1; WBGene00003133.
DR   GeneID; 174698; -.
DR   KEGG; cel:CELE_W10C6.1; -.
DR   CTD; 174698; -.
DR   WormBase; W10C6.1; CE43328; WBGene00003133; mat-2.
DR   eggNOG; KOG1858; Eukaryota.
DR   GeneTree; ENSGT00390000016757; -.
DR   HOGENOM; CLU_248475_0_0_1; -.
DR   InParanoid; O18191; -.
DR   OMA; ASTWNSE; -.
DR   OrthoDB; 738153at2759; -.
DR   PhylomeDB; O18191; -.
DR   Reactome; R-CEL-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:O18191; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00003133; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005680; C:anaphase-promoting complex; IMP:WormBase.
DR   GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR   GO; GO:0008356; P:asymmetric cell division; IMP:UniProtKB.
DR   GO; GO:0051295; P:establishment of meiotic spindle localization; IGI:WormBase.
DR   GO; GO:0044785; P:metaphase/anaphase transition of meiotic cell cycle; IMP:WormBase.
DR   GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IMP:WormBase.
DR   GO; GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW.
DR   GO; GO:0009949; P:polarity specification of anterior/posterior axis; IMP:WormBase.
DR   GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR   GO; GO:0051445; P:regulation of meiotic cell cycle; IC:ComplexPortal.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; IC:ComplexPortal.
DR   GO; GO:1904666; P:regulation of ubiquitin protein ligase activity; IC:ComplexPortal.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR024990; Apc1.
DR   InterPro; IPR011989; ARM-like.
DR   PANTHER; PTHR12827; PTHR12827; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Developmental protein; Meiosis; Mitosis;
KW   Neurotransmitter transport; Reference proteome; Transport;
KW   Ubl conjugation pathway.
FT   CHAIN           1..1505
FT                   /note="Anaphase-promoting complex subunit 1"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000435327"
FT   MUTAGEN         333
FT                   /note="G->R: In ax102; results in sterility."
FT                   /evidence="ECO:0000269|PubMed:11861581"
FT   MUTAGEN         411
FT                   /note="L->F: In ax143 and or224; results in sterility."
FT                   /evidence="ECO:0000269|PubMed:11861581"
FT   MUTAGEN         828
FT                   /note="S->F: In ax102; results in sterility."
FT                   /evidence="ECO:0000269|PubMed:11861581"
FT   MUTAGEN         975
FT                   /note="F->L: In ar104; results in sterility."
FT                   /evidence="ECO:0000269|PubMed:11861581"
FT   MUTAGEN         1196
FT                   /note="M->K: In ax76; maternal-effect lethal."
FT                   /evidence="ECO:0000269|PubMed:11861581"
FT   MUTAGEN         1197
FT                   /note="A->V: In or170; maternal-effect lethal."
FT                   /evidence="ECO:0000269|PubMed:11861581"
FT   MUTAGEN         1297
FT                   /note="R->K: In ax78; maternal-effect lethal."
FT                   /evidence="ECO:0000269|PubMed:11861581"
SQ   SEQUENCE   1505 AA;  169620 MW;  A6C679F547E1B01A CRC64;
     MRKYVLFFIS GNNDSQIWAT TPNTPRVIAR GGLERNIHTR TLARMVNEDA PGTSTPAAQS
     RLQTTASPFH RTHLTQMCRR GDTNASLLRD FTRMIRDTPR NFSKNTQHGN DRDFGDLERD
     PDVDLLLSKV CLECVYVEPK EGAIPKANKI FISNFLSDMY INLVSVTGEV MKIIPIWKNA
     ETTRKNLLEK GKHEPCVVDC VDAAFVMKSG ITVVLGSDFT TAMFGGNERI APIFIKEMSN
     QRVGRKFRLF SFAENRIFAV NEMRCIVVEI PETVTCKSAT ELMRTCFLHL DRDLSRKLLI
     KWRSVKRDVD TERLDLDRKE MIDVAIFMLD NVGVRVTNVV AQERADSPEG HGGKQMRPRM
     SDSEVLSMMR QFFEEMTFRP KSEVITEDGY KCHLSVELDP NGEGFVHTQD LLHAFHSQCE
     DWSINTMMHS ILLELIPYAY LLAKVMNYRA FEEYYVQLFK HLLSQIAIEF KIPPEIHEKF
     VGAIHIPKPC WSLNNVIAHI ICERTTPETM ESIPKFISKS SVRLLTILAV GRKFIGMGTN
     IDMDCERWLG KDWKRRIGLS GDILKSFRRI MNGKSSNSAG RASQLIELFE IGSITIDFMV
     LAVKVLMLKF QTDAFAGAQS IEPKKCIYAT ADEMISIAHL RWKNDIRMHN VQLMLNSSRP
     ILIATNILRK NEDDNMKELQ DRFLTQTSYR TFSQPFGRAF LDFRTAVPSL LTSIYIPRLN
     VGGMIYPSRV TCDPPTTEIF KLCTEWGNFY NSLASALRIG SSETVRIDNE WIVMVSKNIK
     STAVIGGMTL GFGLNGHLAP FNMYHAHQML STFDKFHSVA LLIGLSASNF TTCDVQIHKI
     LATYLSFLMG PTPLEIKLDF TIQTAAISGL GLLFADSGNM TIAKKLVNEI GRAPNRDEEP
     VTDRNAYKLS AGFSLGLIML GKGNGSASTV IPFKQNIPPM SQRLIYMMNG MRRDKCVFLP
     QVAPPVVNDV PNLPFSNGGM MTSSQVANHV KESEYINIHQ SAEPAAIALG MMFMKMNNEF
     IANALALPGT ITELERLKPD SMYSRVLAQC LVMWDSIEPT HDFVKSLIPP VIREYATAAL
     HFGVPIRRDE DGEEVHEAIN DAEEKYWAEI VDKGTVSQTF LYAVSAACMA IALKFSSCGG
     PNEKNIVNTA FRIIEYYTKI VMPDGKSNKD MGSIRMCIYS GAYTRTSCLS MLITAMAILR
     VGTGDLEVMR YARLLRLCDK PESDWIATGK KHFEQMVAHQ ALGILMLGEG RYAFKKDDLS
     IALTIISTFP TIPQSVSDNS HYHQPLRFLW SMAVEPRLLV PFDIAESCVV EVDVTIVMKP
     KDGNEPIVYK EKAPYLLPPL EDLQSISIGG GNYQLVHISL QSEDQVKVMK DIMTIGQGRV
     MLKRYGVDSS EMKIKEATTL YDDTPSLMSM FNNEDTAVEL DEYEIQCMME KIDEGINLNS
     SDEYPNVQIE LSCVRDVTER TTMDLAQLQK RSLKLLSESL DLWQDEVNVS NTINGLADAV
     QDMQI
 
 
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