ID   IDI2_CLAXA              Reviewed;         290 AA.
AC   Q39664;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Isopentenyl-diphosphate Delta-isomerase II;
DE            EC=5.3.3.2;
DE   AltName: Full=Isopentenyl pyrophosphate isomerase II;
DE            Short=IPP isomerase II;
GN   Name=IPI2;
OS   Clarkia xantiana (Gunsight clarkia).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Myrtales; Onagraceae; Onagroideae; Onagreae; Clarkia.
OX   NCBI_TaxID=3938;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Blanc V.M., Mullin K., Pichersky E.;
RT   "Nucleotide sequences of Ipi genes from Arabidopsis and Clarkia.";
RL   (er) Plant Gene Register PGR96-036(1996).
CC   -!- FUNCTION: Catalyzes the 1,3-allylic rearrangement of the homoallylic
CC       substrate isopentenyl (IPP) to its highly electrophilic allylic isomer,
CC       dimethylallyl diphosphate (DMAPP). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=isopentenyl diphosphate = dimethylallyl diphosphate;
CC         Xref=Rhea:RHEA:23284, ChEBI:CHEBI:57623, ChEBI:CHEBI:128769;
CC         EC=5.3.3.2;
CC   -!- PATHWAY: Isoprenoid biosynthesis; dimethylallyl diphosphate
CC       biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate:
CC       step 1/1.
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; chlorophyll
CC       biosynthesis.
CC   -!- SIMILARITY: Belongs to the IPP isomerase type 1 family. {ECO:0000305}.
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DR   EMBL; U48962; AAB67742.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q39664; -.
DR   SMR; Q39664; -.
DR   UniPathway; UPA00059; UER00104.
DR   UniPathway; UPA00668; -.
DR   GO; GO:0004452; F:isopentenyl-diphosphate delta-isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0050992; P:dimethylallyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0015979; P:photosynthesis; IEA:UniProtKB-KW.
DR   CDD; cd02885; IPP_Isomerase; 1.
DR   InterPro; IPR011876; IsopentenylPP_isomerase_typ1.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   InterPro; IPR000086; NUDIX_hydrolase_dom.
DR   Pfam; PF00293; NUDIX; 1.
DR   SUPFAM; SSF55811; SSF55811; 1.
DR   TIGRFAMs; TIGR02150; IPP_isom_1; 1.
DR   PROSITE; PS51462; NUDIX; 1.
PE   3: Inferred from homology;
KW   Chlorophyll biosynthesis; Isomerase; Isoprene biosynthesis; Photosynthesis.
FT   CHAIN           1..290
FT                   /note="Isopentenyl-diphosphate Delta-isomerase II"
FT                   /id="PRO_0000205238"
FT   DOMAIN          108..260
FT                   /note="Nudix hydrolase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00794"
FT   ACT_SITE        145
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        207
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   290 AA;  32936 MW;  38DFBB1DE7CCB674 CRC64;
     MSLTSRLYKP RLFSLPSQHS FRALPILSPP LRSSCIPAPL SVRASLSTRS IATSIAMGEA
     AADAGMDAVQ RRLMFDDECI LVDEVDCVVG HESKYNCHLW EKIESGNMLH RAFTVFLFNS
     KFELLLQQRS ATKVTFPLVW TNTCCSHPLY RESELIDENN LGVRNAAQRK LLDELGIPAE
     DVPVDEFTPV SRMLYKAPSD GKWGEHELDY LLFIVRDVGI HPNPDEVADI KYVNREQLKE
     LLRKADAGEE GLKLSPWFRL VVDNFLPKWW DHVEKGTLSE AVDMKTIHNL