APC1_DICDI
ID APC1_DICDI Reviewed; 2269 AA.
AC Q54NC6;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Anaphase-promoting complex subunit 1;
DE Short=APC1;
GN Name=anapc1; Synonyms=apc1; ORFNames=DDB_G0285349;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex
CC that controls progression through mitosis and the G1 phase of the cell
CC cycle. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: The APC/C is composed of at least 13 subunits that stay
CC tightly associated throughout the cell cycle: anapc1, anapc2, anapc3,
CC anapc4, anapc5, anapc6, anapc7, anapc8, anapc10, anapc11, cdc20, cdc26
CC and cdh1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the APC1 family. {ECO:0000305}.
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DR EMBL; AAFI02000079; EAL64749.1; -; Genomic_DNA.
DR RefSeq; XP_638254.1; XM_633162.1.
DR AlphaFoldDB; Q54NC6; -.
DR SMR; Q54NC6; -.
DR STRING; 44689.DDB0234263; -.
DR PaxDb; Q54NC6; -.
DR EnsemblProtists; EAL64749; EAL64749; DDB_G0285349.
DR GeneID; 8625062; -.
DR KEGG; ddi:DDB_G0285349; -.
DR dictyBase; DDB_G0285349; anapc1.
DR eggNOG; KOG1858; Eukaryota.
DR HOGENOM; CLU_001202_1_0_1; -.
DR InParanoid; Q54NC6; -.
DR OMA; MQPPDSR; -.
DR PhylomeDB; Q54NC6; -.
DR Reactome; R-DDI-141430; Inactivation of APC/C via direct inhibition of the APC/C complex.
DR Reactome; R-DDI-174048; APC/C:Cdc20 mediated degradation of Cyclin B.
DR Reactome; R-DDI-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR Reactome; R-DDI-174154; APC/C:Cdc20 mediated degradation of Securin.
DR Reactome; R-DDI-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR Reactome; R-DDI-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR Reactome; R-DDI-176407; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
DR Reactome; R-DDI-176408; Regulation of APC/C activators between G1/S and early anaphase.
DR Reactome; R-DDI-176409; APC/C:Cdc20 mediated degradation of mitotic proteins.
DR Reactome; R-DDI-176412; Phosphorylation of the APC/C.
DR Reactome; R-DDI-179409; APC-Cdc20 mediated degradation of Nek2A.
DR Reactome; R-DDI-2467813; Separation of Sister Chromatids.
DR Reactome; R-DDI-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR Reactome; R-DDI-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-DDI-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q54NC6; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005680; C:anaphase-promoting complex; ISS:dictyBase.
DR GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IC:dictyBase.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR024990; Apc1.
DR InterPro; IPR041221; APC1_C.
DR InterPro; IPR011989; ARM-like.
DR PANTHER; PTHR12827; PTHR12827; 1.
DR Pfam; PF18122; APC1_C; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Mitosis; Nucleus; Reference proteome; Repeat;
KW Ubl conjugation pathway.
FT CHAIN 1..2269
FT /note="Anaphase-promoting complex subunit 1"
FT /id="PRO_0000328275"
FT REPEAT 1440..1472
FT /note="PC 1"
FT REPEAT 1483..1520
FT /note="PC 2"
FT REPEAT 1605..1637
FT /note="PC 3"
FT REPEAT 1722..1756
FT /note="PC 4"
FT REPEAT 1792..1807
FT /note="PC 5"
FT REGION 305..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1136..1197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1535..1586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1960..1997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2269 AA; 258585 MW; E18033096FA6F04A CRC64;
MVSIINLGKV KPFGLSYIIN SNNNNNNNDD DDYNNEIRES ESSIPYEYYF CQNPLKSCFN
EEQKILLQSE NDETDEKGMI LVNNSFFEEA QLFWYQNTVV WSSPFTVKKK FTLPLLLSSM
IYPKINNAIW SHFPFLKDLS KQQQEQQQQQ HHQQSEYTTS SINNDIDDYY KYLCVLHNQG
LNIYNSIGNS YQIVLPCKVI NIWSSKFGLL LERDSSLDST LLAGRDRSEI PSIFSILNPL
EELKPVLTFS KSNNNNNNNN EALQQEFFSD TNQTIVFSST DYPILITYSN IENVHIIYQV
SHVKPSSNAE NDNTNNNNNN NNTNTNISNN QTINNENGTT TTIINNSSIV NTSKPIFNFN
NVSVNDQSFD YSNINISSSS PPFSSRNNNN NNNISNNNNT NNNTNNNNTN NSTSMMQQSI
QQQQQQQQQQ ENSSFKFLNE DKSYFFDDES EFIIKSEIIF EEVLKDSTRL KSNTKSKSIF
ITLDNNQKPL LCIEINSTLF CYNLFIDQKI KSTQSSSSNK NNNNNNDRNE GIEEKLKLEF
SFSISSVQSS SPIFIESFYN NNEYTIPKGI NQPFIPLPTH ILVLNDHLLS VYWGPFKILD
LPIDNNSNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNK RKPLYIKDST FNRVTIVYSD
KEEIRFKITL GKSYLVSSCL GALSSFIPMN LLASIYQDFN DFHKFRINNL LNSNSNNNNN
NNNSEEENDK EWISFQILLI SLLEKSLLKR PTDADTNKKI KENNHIKKEE NEDDWEFLLN
SNYHKNYEKG LSFLSNLNIS DSSKVYPSNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
NNNNNNNNNN CNIFIESIND FNFKTSLNSF IESIDDIIIA LHHQYEEFKI LTFNINYIYK
LSKFLIQLSL HLELFNYVDY YFRDFGDLID FINQFKIKSK TSIDISSLKL QSLLNDDIFS
IYKFVYNSFN ENNSETQQQQ QFNKEKFERN KLTKYHFKWI YKMKSLYSIQ SKINDNNSNN
KNNIKYISEK LIMKMVELDI KLEDLNSISF GLSLPLRESI KYCRSNPPID WPLKAYSLIE
REELIYKFNI DDVNNVKDGL KINSLLISGG KNKLLSNSTM NHGYNSLSTS ITNTLSTASS
SSNEMNSNSN ITSINGQSNG LPMNSTTNQM NSHQINNNGG GGGGGDDHHH HHSNSTSFDL
SKFYHGQDEF YKRITYLRFD TDQRIQEVYR LLSFSNRIQI NHTQENGVSD HDYLSQLQSK
LLLSVQRSIS LPIACGMFTI RSIKPLPTET INIPPIILNG FVGGTKTNIS LDPTMVQDNM
MVWPEFHNGV AAGLKVSADQ TEITNTWIIY NRPKQFNPSY SGLLMALGLQ KRLSSLAFTK
LFEYLASGHQ LTSVGLLLGI SCTKMGTMDM SIAKVLSVHI QSLHPPLSID LDVPSYVQIA
ALMGIGLLYC QTSNRRMTEV LLMEIGRKPI NDKPLDRDSY SLTAGMALGL VNLGKGANEG
SLTDLHVEDR LRSFIGISKE DSFDHMSTFF NQSYSTPSIS SNRNNNDLFN NGSNNNSSSN
GGGGGGGGNN NGNNSNNGNN GSSQFKKSNT ILESSKPNID LTAPGAIIAL SLIYLKTNNL
KISNYLSIPD TTFGLNYIRP DLVLLRILGR NLILWDSIKP QFQWIIDSVP LVVRKNVTID
RNSEKVFQEH SNNNNNNNKS RSSSSLNDFE SFILIFCNVI AGAAFSIGLK YAGSLNENAF
SLLMDLIQLF RKRQVYLNKC LLKKKKIEPT FDKVMRVTTE TCLNVVALSL SLVMAGSGNL
ETLKILRMLR SRIGNEITYG NHMAINMAIG FLFLGGGQYT LSTSNIAIAS LVCSLYPRFP
CSSTDNDYHL QAFRHLYFLA IDPRCLITRD VDTLAPCHVP IELTILNNDT MKLETKQLVT
PCLIPELSSI RSISIKSPRY WNIFINRGFV DGGVDININN NNNNNNNNNN NNNNNNNNNN
NNNNNNNNNN NNNKNILKNH PTIFLKRKIG HLPYTEDPEG FRSLSKSFPK SESISLYSSS
KGFQKNKEEF LKSFISDPNL LAFAKHFCTN QSNEFEHFNT TILYECLTQD TPEVIPLLLL
LNDIANNFEK YSNSNTTIVL ENLRIIFKFY SKWNNGYYLN NNNNKNNNND GWLIHSTFLD
SISTKIDEHF EKHFLNEQSN KKLLSNYLLT GELPNSLSTS IKRKFASFIS YYNLPNNKQF
QSFKSLLNNN NNNNSNAIYQ LWSSLGNQIN FNSINKIIEL STLSFDEDS
