APC2_DICDI
ID APC2_DICDI Reviewed; 907 AA.
AC Q551S9; Q8T129;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Anaphase-promoting complex subunit 2;
GN Name=anapc2; Synonyms=apc2; ORFNames=DDB_G0276377;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex
CC that controls progression through mitosis and the G1 phase of the cell
CC cycle. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: The APC/C is composed of at least 13 subunits that stay
CC tightly associated throughout the cell cycle: anapc1, anapc2, anapc3,
CC anapc4, anapc5, anapc6, anapc7, anapc8, anapc10, anapc11, cdc20, cdc26
CC and cdh1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cullin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00330}.
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DR EMBL; AAFI02000014; EAL69269.1; -; Genomic_DNA.
DR RefSeq; XP_643183.1; XM_638091.1.
DR AlphaFoldDB; Q551S9; -.
DR SMR; Q551S9; -.
DR STRING; 44689.DDB0234264; -.
DR PaxDb; Q551S9; -.
DR PRIDE; Q551S9; -.
DR EnsemblProtists; EAL69269; EAL69269; DDB_G0276377.
DR GeneID; 8620454; -.
DR KEGG; ddi:DDB_G0276377; -.
DR dictyBase; DDB_G0276377; anapc2.
DR eggNOG; KOG2165; Eukaryota.
DR HOGENOM; CLU_007149_2_0_1; -.
DR InParanoid; Q551S9; -.
DR OMA; FMYETFA; -.
DR PhylomeDB; Q551S9; -.
DR Reactome; R-DDI-141430; Inactivation of APC/C via direct inhibition of the APC/C complex.
DR Reactome; R-DDI-174048; APC/C:Cdc20 mediated degradation of Cyclin B.
DR Reactome; R-DDI-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR Reactome; R-DDI-174154; APC/C:Cdc20 mediated degradation of Securin.
DR Reactome; R-DDI-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR Reactome; R-DDI-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR Reactome; R-DDI-176407; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
DR Reactome; R-DDI-176408; Regulation of APC/C activators between G1/S and early anaphase.
DR Reactome; R-DDI-176409; APC/C:Cdc20 mediated degradation of mitotic proteins.
DR Reactome; R-DDI-176412; Phosphorylation of the APC/C.
DR Reactome; R-DDI-179409; APC-Cdc20 mediated degradation of Nek2A.
DR Reactome; R-DDI-2467813; Separation of Sister Chromatids.
DR Reactome; R-DDI-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR Reactome; R-DDI-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-DDI-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q551S9; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005680; C:anaphase-promoting complex; ISS:dictyBase.
DR GO; GO:0005829; C:cytosol; ISS:dictyBase.
DR GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IC:dictyBase.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IC:dictyBase.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR044554; APC2-like.
DR InterPro; IPR014786; APC2_C.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45957; PTHR45957; 1.
DR Pfam; PF08672; ANAPC2; 1.
DR Pfam; PF00888; Cullin; 1.
DR SMART; SM01013; APC2; 1.
DR SMART; SM00182; CULLIN; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF75632; SSF75632; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Mitosis; Nucleus; Reference proteome;
KW Ubl conjugation pathway.
FT CHAIN 1..907
FT /note="Anaphase-promoting complex subunit 2"
FT /id="PRO_0000328276"
FT REGION 203..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..228
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..806
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..826
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 907 AA; 107067 MW; 1AFAF81A41F0DA67 CRC64;
MFQNKEQTES ILVWEKIVSI FSIPSQNEIL NFKQKSPNNI DNNLKQLFNF VKLYKLESLV
LDWYFESIKK YFKSTLSNEF WKFFNNVNLA ELDSSTTSGR QLKFINHQFA LSINLLHKVF
SFFKSNLFLF YELLFKKESY NFNFLIKKLQ DLLITNIMHT TNQQTKYFNT ILFMFFERDF
ISFTKSFYHS KKQILKDEEE NNNNSKDLEF NDQQQEEEEE EEENEEESKS YIIMEMSFED
SITDINIKED SFMDLCKKLQ DLNFIVISEE IFTQILFKKV FEYIETRCKG VFEKSFLKSI
LEWADQVIFK WLAMILLSST TTTKINNYND IINNNDDDND DDDDDENKEN SLKIFNQWKK
RLEFSIYENY SQQRISELFD MIVQYPDSLP SLEDLSICFQ KIPIEKTMIT NLKRVLHNRL
LHPGANTSDI ITQYISTIHA MDIIDPSGMV MEKVGKPIRE YLSQREDTIR CIISSFTEES
NEIYQELCNY DPQDNGGDDD SNNSLLAFGN CDLYVDEGDN FSSIDDFKFW IPNKIDGSST
TISIGNAKAN NNNKKKKKKD TISHLVNIYD GIDLFINEYR SMLSDRLLSV VDFDLDKEIK
NIELLKLRFG DSVLFNCEIM IKDMVDSKRL NLQIKNSQGV NNNNNNNNNN NNELKEFETL
ILSQLFWPTL KGDEFKYPKS IEKKMQIYSK EYERIKTPRQ LIWKQHLGLV DLDLEIGNNI
QSFQVSPIHA TLIMLFESDD GDDDDEKELT LEYLSKQLEI SKDLVKKKLI FWLNNQIIKE
TSHETYKINN KEKEEQKQRQ QQIENDDQDE SSSDDDDDDN NIVVEEEEEE KSTSAKEKEE
QMRVVESFII GMLINFKTLP LERIHSMLTM FNSELYTSTI HELKAFLSKL VNEEKIELVG
NDFKIKK
