位置:首页 > 蛋白库 > APC4_ARATH
APC4_ARATH
ID   APC4_ARATH              Reviewed;         777 AA.
AC   O65418;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   10-AUG-2010, sequence version 2.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=Anaphase-promoting complex subunit 4;
DE   AltName: Full=Cyclosome subunit 4;
GN   Name=APC4; OrderedLocusNames=At4g21530; ORFNames=F18E5.150;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC       (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex
CC       that controls progression through mitosis and the G1 phase of the cell
CC       cycle. The APC/C complex controls several key steps in the cell cycle
CC       by mediating ubiquitination and subsequent degradation of target
CC       proteins such as cyclins. The APC/C complex is required for the female
CC       gametophyte development and is involved in several aspect of
CC       development by controlling cell division and cell elongation. Involved
CC       in the control of endoreduplication (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: The APC/C is composed of at least 10 subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the APC4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AK228871; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=CAA18717.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAB81260.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL022603; CAA18717.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL161555; CAB81260.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002687; AEE84463.1; -; Genomic_DNA.
DR   EMBL; AK228871; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; T05161; T05161.
DR   RefSeq; NP_193884.6; NM_118273.8.
DR   AlphaFoldDB; O65418; -.
DR   SASBDB; O65418; -.
DR   SMR; O65418; -.
DR   BioGRID; 13527; 11.
DR   IntAct; O65418; 11.
DR   STRING; 3702.AT4G21530.1; -.
DR   PaxDb; O65418; -.
DR   PRIDE; O65418; -.
DR   ProteomicsDB; 240882; -.
DR   EnsemblPlants; AT4G21530.1; AT4G21530.1; AT4G21530.
DR   GeneID; 828238; -.
DR   Gramene; AT4G21530.1; AT4G21530.1; AT4G21530.
DR   KEGG; ath:AT4G21530; -.
DR   Araport; AT4G21530; -.
DR   TAIR; locus:2119627; AT4G21530.
DR   eggNOG; KOG1116; Eukaryota.
DR   eggNOG; KOG4640; Eukaryota.
DR   HOGENOM; CLU_018724_1_0_1; -.
DR   InParanoid; O65418; -.
DR   OMA; HCKLFVP; -.
DR   OrthoDB; 351579at2759; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:O65418; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; O65418; baseline and differential.
DR   GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR   GO; GO:0034399; C:nuclear periphery; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IMP:TAIR.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.
DR   GO; GO:0048481; P:plant ovule development; IMP:TAIR.
DR   GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR   GO; GO:0030071; P:regulation of mitotic metaphase/anaphase transition; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR024789; APC4.
DR   InterPro; IPR024790; APC4_long_dom.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR13260; PTHR13260; 1.
DR   Pfam; PF12896; ANAPC4; 1.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   SMART; SM00320; WD40; 2.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Mitosis; Nucleus; Reference proteome; Repeat;
KW   Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..777
FT                   /note="Anaphase-promoting complex subunit 4"
FT                   /id="PRO_0000396841"
FT   REPEAT          22..62
FT                   /note="WD 1"
FT   REPEAT          63..103
FT                   /note="WD 2"
FT   REPEAT          105..141
FT                   /note="WD 3"
SQ   SEQUENCE   777 AA;  87420 MW;  2308A4B755136B16 CRC64;
     MSEMASDEEE NIIPFQLQFD KPIPFQIKIA EWNPEKDLLA MVTEDSKILL HRFNWQRLWT
     ISPGKPVTSL CWRPDGKAIA VGLEDGTISL HDVENGKLLR NLKPHDVAVV CLNWEEDGQS
     NTDESGNFSV YEDRTSRFFP PAPRPPKMPG LVAGDSSFMD DGEDSLAELS NTSFRKFNIL
     CTGDRDGNIC FSIFGIFQIG KINIHELSLP VPHLDEHASC KLFNASIYKV ALSKDLCRLV
     VMCTGELKDC DIKPREEKIN VQDLPGLHCL AMDTSIFWKR KYELHQVAQQ ASNIEDLTEV
     IRASLSVMNK QWADAMKTFH EKFHSLSTLI IDNGLESSPQ EEFLSLLGGA RISPALNQFL
     VNSLGEVGVK RVLKSVCGTG KELQQVVLDH LQPAAEIIGF RIGELRGLSR WRARYQGIGL
     DEMLLNEATE NTGLLLVQVQ RFMMVLSSVV QQFSNFFNWL VRSIKYLMQE PNDQLLSYNS
     ELLVVFLKFL YDQDPVKDLL ELSEAGDDIE IDLKTIGRVK ELLQFGGFSE CDFLQRTLAK
     EFQHMESSFK MAFQMPFTTI SRKISCMKLL PLCPLQLSTT QTPTTIPMSL SFYKNELSDD
     TPCQSGYTDY ISFQVPDETF PEISNCIGIA KGYKQNSNNE KNGYTSLEAV LLSVPNGYTC
     VDLSLYKDKE LVLLLNKTNT DSEGSGEACM MVVQTGDLAF ISISGSSSLN QWELEDLKGS
     IVNLEMENEK VRKVPHSVIA PLAVSASRGV ACVFAERRRA LVYILEEDED EEISDEK
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024