APC4_ARATH
ID APC4_ARATH Reviewed; 777 AA.
AC O65418;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 10-AUG-2010, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Anaphase-promoting complex subunit 4;
DE AltName: Full=Cyclosome subunit 4;
GN Name=APC4; OrderedLocusNames=At4g21530; ORFNames=F18E5.150;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex
CC that controls progression through mitosis and the G1 phase of the cell
CC cycle. The APC/C complex controls several key steps in the cell cycle
CC by mediating ubiquitination and subsequent degradation of target
CC proteins such as cyclins. The APC/C complex is required for the female
CC gametophyte development and is involved in several aspect of
CC development by controlling cell division and cell elongation. Involved
CC in the control of endoreduplication (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: The APC/C is composed of at least 10 subunits. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the APC4 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AK228871; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAA18717.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB81260.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL022603; CAA18717.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161555; CAB81260.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE84463.1; -; Genomic_DNA.
DR EMBL; AK228871; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; T05161; T05161.
DR RefSeq; NP_193884.6; NM_118273.8.
DR AlphaFoldDB; O65418; -.
DR SASBDB; O65418; -.
DR SMR; O65418; -.
DR BioGRID; 13527; 11.
DR IntAct; O65418; 11.
DR STRING; 3702.AT4G21530.1; -.
DR PaxDb; O65418; -.
DR PRIDE; O65418; -.
DR ProteomicsDB; 240882; -.
DR EnsemblPlants; AT4G21530.1; AT4G21530.1; AT4G21530.
DR GeneID; 828238; -.
DR Gramene; AT4G21530.1; AT4G21530.1; AT4G21530.
DR KEGG; ath:AT4G21530; -.
DR Araport; AT4G21530; -.
DR TAIR; locus:2119627; AT4G21530.
DR eggNOG; KOG1116; Eukaryota.
DR eggNOG; KOG4640; Eukaryota.
DR HOGENOM; CLU_018724_1_0_1; -.
DR InParanoid; O65418; -.
DR OMA; HCKLFVP; -.
DR OrthoDB; 351579at2759; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:O65418; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O65418; baseline and differential.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0034399; C:nuclear periphery; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IMP:TAIR.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.
DR GO; GO:0048481; P:plant ovule development; IMP:TAIR.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR GO; GO:0030071; P:regulation of mitotic metaphase/anaphase transition; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR024789; APC4.
DR InterPro; IPR024790; APC4_long_dom.
DR InterPro; IPR024977; Apc4_WD40_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13260; PTHR13260; 1.
DR Pfam; PF12896; ANAPC4; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Mitosis; Nucleus; Reference proteome; Repeat;
KW Ubl conjugation pathway; WD repeat.
FT CHAIN 1..777
FT /note="Anaphase-promoting complex subunit 4"
FT /id="PRO_0000396841"
FT REPEAT 22..62
FT /note="WD 1"
FT REPEAT 63..103
FT /note="WD 2"
FT REPEAT 105..141
FT /note="WD 3"
SQ SEQUENCE 777 AA; 87420 MW; 2308A4B755136B16 CRC64;
MSEMASDEEE NIIPFQLQFD KPIPFQIKIA EWNPEKDLLA MVTEDSKILL HRFNWQRLWT
ISPGKPVTSL CWRPDGKAIA VGLEDGTISL HDVENGKLLR NLKPHDVAVV CLNWEEDGQS
NTDESGNFSV YEDRTSRFFP PAPRPPKMPG LVAGDSSFMD DGEDSLAELS NTSFRKFNIL
CTGDRDGNIC FSIFGIFQIG KINIHELSLP VPHLDEHASC KLFNASIYKV ALSKDLCRLV
VMCTGELKDC DIKPREEKIN VQDLPGLHCL AMDTSIFWKR KYELHQVAQQ ASNIEDLTEV
IRASLSVMNK QWADAMKTFH EKFHSLSTLI IDNGLESSPQ EEFLSLLGGA RISPALNQFL
VNSLGEVGVK RVLKSVCGTG KELQQVVLDH LQPAAEIIGF RIGELRGLSR WRARYQGIGL
DEMLLNEATE NTGLLLVQVQ RFMMVLSSVV QQFSNFFNWL VRSIKYLMQE PNDQLLSYNS
ELLVVFLKFL YDQDPVKDLL ELSEAGDDIE IDLKTIGRVK ELLQFGGFSE CDFLQRTLAK
EFQHMESSFK MAFQMPFTTI SRKISCMKLL PLCPLQLSTT QTPTTIPMSL SFYKNELSDD
TPCQSGYTDY ISFQVPDETF PEISNCIGIA KGYKQNSNNE KNGYTSLEAV LLSVPNGYTC
VDLSLYKDKE LVLLLNKTNT DSEGSGEACM MVVQTGDLAF ISISGSSSLN QWELEDLKGS
IVNLEMENEK VRKVPHSVIA PLAVSASRGV ACVFAERRRA LVYILEEDED EEISDEK
