IDIA_SYNE7
ID IDIA_SYNE7 Reviewed; 357 AA.
AC Q31L64; Q93IP4;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Iron deficiency-induced protein A;
DE Flags: Precursor;
GN Name=idiA; OrderedLocusNames=Synpcc7942_2175;
OS Synechococcus elongatus (strain PCC 7942 / FACHB-805) (Anacystis nidulans
OS R2).
OC Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX NCBI_TaxID=1140;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Toelle J.;
RL Thesis (2001), University of Bielefeld, Germany.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7942 / FACHB-805;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M.,
RA Kyrpides N., Lykidis A., Richardson P.;
RT "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP MUTANT STUDIES, AND INDUCTION.
RX PubMed=8828233; DOI=10.1099/00221287-142-9-2635;
RA Michel K.-P., Thole H.H., Pistorius E.K.;
RT "IdiA, a 34 kDa protein in the cyanobacteria Synechococcus sp. strains PCC
RT 6301 and PCC 7942, is required for growth under iron and manganese
RT limitations.";
RL Microbiology 142:2635-2645(1996).
RN [4]
RP INDUCTION, AND REGULATION BY IDIB AND DPSA.
RX PubMed=10411274; DOI=10.1099/13500872-145-6-1473;
RA Michel K.-P., Krueger F., Puehler A., Pistorius E.K.;
RT "Molecular characterization of idiA and adjacent genes in the cyanobacteria
RT Synechococcus sp. strains PCC 6301 and PCC 7942.";
RL Microbiology 145:1473-1484(1999).
RN [5]
RP FUNCTION IN PSII PROTECTION.
RX PubMed=16228425; DOI=10.1023/a:1006322925324;
RA Exss-Sonne P., Toelle J., Bader K.P., Pistorius E.K., Michel K.-P.;
RT "The IdiA protein of Synechococcus sp. PCC 7942 functions in protecting the
RT acceptor side of Photosystem II under oxidative stress.";
RL Photosyn. Res. 63:145-157(2000).
RN [6]
RP REGULATION BY IDIB AND FUR.
RX PubMed=11489854; DOI=10.1128/jb.183.17.5015-5024.2001;
RA Michel K.-P., Pistorius E.K., Golden S.S.;
RT "Unusual regulatory elements for iron deficiency induction of the idiA gene
RT of Synechococcus elongatus PCC 7942.";
RL J. Bacteriol. 183:5015-5024(2001).
RN [7]
RP REGULATION BY IDIB.
RX PubMed=14605795; DOI=10.1007/s00203-003-0618-4;
RA Yousef N., Pistorius E.K., Michel K.-P.;
RT "Comparative analysis of idiA and isiA transcription under iron starvation
RT and oxidative stress in Synechococcus elongatus PCC 7942 wild-type and
RT selected mutants.";
RL Arch. Microbiol. 180:471-483(2003).
CC -!- FUNCTION: Plays an important role in protecting the acceptor side of
CC photosystem II (PSII) against oxidative damage, especially under iron-
CC limiting growth conditions. {ECO:0000269|PubMed:16228425}.
CC -!- FUNCTION: May also be part of a periplasmic ABC transporter complex
CC involved in iron import. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cellular thylakoid membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Lumenal side {ECO:0000250}.
CC -!- INDUCTION: By iron limitation and to a smaller extent by manganese
CC limitation. Regulated by IdiB. May also be indirectly regulated by DpsA
CC and Fur. {ECO:0000269|PubMed:10411274, ECO:0000269|PubMed:8828233}.
CC -!- PTM: Predicted to be exported by the Tat system. The position of the
CC signal peptide cleavage has not been experimentally proven.
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 1 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABB58205.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ319672; CAC40996.1; -; Genomic_DNA.
DR EMBL; CP000100; ABB58205.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; Q31L64; -.
DR SMR; Q31L64; -.
DR STRING; 1140.Synpcc7942_2175; -.
DR PRIDE; Q31L64; -.
DR EnsemblBacteria; ABB58205; ABB58205; Synpcc7942_2175.
DR KEGG; syf:Synpcc7942_2175; -.
DR eggNOG; COG1840; Bacteria.
DR HOGENOM; CLU_026974_2_1_3; -.
DR BioCyc; SYNEL:SYNPCC7942_2175-MON; -.
DR GO; GO:0031676; C:plasma membrane-derived thylakoid membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR InterPro; IPR026045; Ferric-bd.
DR InterPro; IPR006311; TAT_signal.
DR PIRSF; PIRSF002825; CfbpA; 1.
DR PROSITE; PS51318; TAT; 1.
PE 1: Evidence at protein level;
KW Ion transport; Iron; Iron transport; Membrane; Metal-binding; Signal;
KW Thylakoid; Transport.
FT SIGNAL 1..36
FT /note="Tat-type signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00648"
FT CHAIN 37..357
FT /note="Iron deficiency-induced protein A"
FT /id="PRO_5000067709"
FT BINDING 48
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 49
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 182
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 238
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 239
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
SQ SEQUENCE 357 AA; 39243 MW; 209F41291845F14D CRC64;
MSESMFSRRD FLLGGTALAG TLLLDSFGDW RRRAEAAEGE VNLYSGRHYN TDNQIYREFT
QKTGIKVNLI EGEADALLAR LKSEGSRSPA DVFITVDAGR LWQATQANLL RPLTQAQAPK
LYQAVPANLR DPQGRWFALS KRARVIMYNR DRVNASQLST YEDLANPKWR NQILVRSSSN
VYNLSLTGEM IAADGAAKTE AWARGLVQNF ARQPQGGDTP QILACAAGVG SLAIANTYYL
VRLFKSKKAE EREAARKIKV FFPNQKGRGT HVNISGAGIV RTAPNPRAAQ LLLEYLLSSQ
AQAVFARGNG EYPVLRGVSL DPILAGFGQF KESKISASVF GANNAQALQL MDRAGWK
