ID   IDIA_THEVB              Reviewed;         355 AA.
AC   Q8DLH9;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Iron deficiency-induced protein A;
DE   Flags: Precursor;
GN   Name=idiA; OrderedLocusNames=tll0513;
OS   Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1).
OC   Bacteria; Cyanobacteria; Pseudanabaenales; Thermosynechococcaceae;
OC   Thermosynechococcus.
OX   NCBI_TaxID=197221;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIES-2133 / IAM M-273 / BP-1;
RX   PubMed=12240834; DOI=10.1093/dnares/9.4.123;
RA   Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S.,
RA   Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C.,
RA   Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takeuchi C., Yamada M., Tabata S.;
RT   "Complete genome structure of the thermophilic cyanobacterium
RT   Thermosynechococcus elongatus BP-1.";
RL   DNA Res. 9:123-130(2002).
RN   [2]
RP   SUBCELLULAR LOCATION, AND INDUCTION.
RX   PubMed=9599805; DOI=10.1007/s004250050298;
RA   Michel K.-P., Exss-Sonne P., Scholten-Beck G., Kahmann U., Ruppel H.G.,
RA   Pistorius E.K.;
RT   "Immunocytochemical localization of IdiA, a protein expressed under iron or
RT   manganese limitation in the mesophilic cyanobacterium Synechococcus PCC
RT   6301 and the thermophilic cyanobacterium Synechococcus elongatus.";
RL   Planta 205:73-81(1998).
CC   -!- FUNCTION: Plays an important role in protecting the acceptor side of
CC       photosystem II (PSII) against oxidative damage, especially under iron-
CC       limiting growth conditions. {ECO:0000250}.
CC   -!- FUNCTION: May also be part of a periplasmic ABC transporter complex
CC       involved in iron import. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cellular thylakoid membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Lumenal side {ECO:0000250}.
CC   -!- INDUCTION: By iron limitation and to a smaller extent by manganese
CC       limitation. {ECO:0000269|PubMed:9599805}.
CC   -!- PTM: Predicted to be exported by the Tat system. The position of the
CC       signal peptide cleavage has not been experimentally proven.
CC   -!- SIMILARITY: Belongs to the bacterial solute-binding protein 1 family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Association with the cytoplasmic side of the thylakoid
CC       membrane proposed in PubMed:9599805 is at odds with the subcellular
CC       location of orthologs in Synechocystis PCC 6803 and the presence of a
CC       signal peptide in this protein. {ECO:0000305}.
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DR   EMBL; BA000039; BAC08065.1; -; Genomic_DNA.
DR   RefSeq; NP_681303.1; NC_004113.1.
DR   RefSeq; WP_011056364.1; NC_004113.1.
DR   AlphaFoldDB; Q8DLH9; -.
DR   SMR; Q8DLH9; -.
DR   STRING; 197221.22294234; -.
DR   EnsemblBacteria; BAC08065; BAC08065; BAC08065.
DR   KEGG; tel:tll0513; -.
DR   PATRIC; fig|197221.4.peg.541; -.
DR   eggNOG; COG1840; Bacteria.
DR   OMA; TLPYNTE; -.
DR   OrthoDB; 1567509at2; -.
DR   Proteomes; UP000000440; Chromosome.
DR   GO; GO:0031676; C:plasma membrane-derived thylakoid membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   InterPro; IPR026045; Ferric-bd.
DR   PIRSF; PIRSF002825; CfbpA; 1.
PE   2: Evidence at transcript level;
KW   Ion transport; Iron; Iron transport; Membrane; Metal-binding;
KW   Reference proteome; Signal; Thylakoid; Transport.
FT   SIGNAL          1..34
FT                   /note="Tat-type signal"
FT                   /evidence="ECO:0000255"
FT   CHAIN           35..355
FT                   /note="Iron deficiency-induced protein A"
FT                   /id="PRO_0000345608"
FT   BINDING         49
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         50
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         180
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         236
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         237
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   355 AA;  39281 MW;  7A0EF573977C4335 CRC64;
     MEKVGRRVFL GMGAAATAYV THHLWNQNAE SSYAQQSSGG VINVYSARHY DTDKALYNTF
     TQQTGIRVNI IEAEADALIE RIRSEGSRTP ADVLITVDAG RLWRAQEAGI LQPIQSRVLN
     SVVPANLREP QGHWFGLSRR VRVLIYNKSR VNPSQLSTYE DLANPKWRRQ ILTRSSSNIY
     NQSLTGSLLA IHGAQKTEQW ARGLVQNFAR PPEGNDTAQI RACAEGVGSV AIANHYYLAR
     LIASDKEQDR AVAAKVGLFF PNQRDRGAHV NISGAGVVAG APNRQGAIRF LEYLVSPKAQ
     EMFAMANFEY PVRAGVPVHP IVKQFGNFRG QNVNAAVFGR NNAEALRIMD RAGWR