ID   APC5C_XENLA             Reviewed;         150 AA.
AC   Q641B9;
DT   10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Actin-related protein 2/3 complex subunit 5-C {ECO:0000305};
GN   Name=arpc5-c; ORFNames=XELAEV_18025332mg {ECO:0000312|EMBL:OCT82798.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J;
RX   PubMed=27762356; DOI=10.1038/nature19840;
RA   Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S.,
RA   Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J., Quigley I.,
RA   Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B., Simakov O.,
RA   Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T., Watanabe M.,
RA   Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S., van Kruijsbergen I.,
RA   Shu S., Carlson J., Kinoshita T., Ohta Y., Mawaribuchi S., Jenkins J.,
RA   Grimwood J., Schmutz J., Mitros T., Mozaffari S.V., Suzuki Y., Haramoto Y.,
RA   Yamamoto T.S., Takagi C., Heald R., Miller K., Haudenschild C., Kitzman J.,
RA   Nakayama T., Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V.,
RA   Karimi K., Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W.,
RA   Shendure J., DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M.,
RA   Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y., Veenstra G.J.,
RA   Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.;
RT   "Genome evolution in the allotetraploid frog Xenopus laevis.";
RL   Nature 538:336-343(2016).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Arp2/3 complex, a multiprotein complex that
CC       mediates actin polymerization upon stimulation by nucleation-promoting
CC       factor (NPF). The Arp2/3 complex mediates the formation of branched
CC       actin networks in the cytoplasm, providing the force for cell motility
CC       (By similarity). In addition to its role in the cytoplasmic
CC       cytoskeleton, the Arp2/3 complex also promotes actin polymerization in
CC       the nucleus, thereby regulating gene transcription and repair of
CC       damaged DNA (By similarity). The Arp2/3 complex promotes homologous
CC       recombination (HR) repair in response to DNA damage by promoting
CC       nuclear actin polymerization, leading to drive motility of double-
CC       strand breaks (DSBs) (By similarity). {ECO:0000250|UniProtKB:O15511,
CC       ECO:0000250|UniProtKB:Q68FI4, ECO:0000250|UniProtKB:Q6DE18}.
CC   -!- SUBUNIT: Component of the Arp2/3 complex composed of actr2/arp2,
CC       actr3/arp3, arpc1 (arpc1a or arpc1b), arpc2, arpc3, arpc4 and arpc5.
CC       {ECO:0000250|UniProtKB:Q6DE18}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q68FI4}. Cell projection
CC       {ECO:0000250|UniProtKB:Q68FI4}. Nucleus {ECO:0000250|UniProtKB:Q6DE18}.
CC   -!- SIMILARITY: Belongs to the ARPC5 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC082419; AAH82419.1; -; mRNA.
DR   EMBL; CM004473; OCT82798.1; -; Genomic_DNA.
DR   RefSeq; NP_001087884.1; NM_001094415.1.
DR   AlphaFoldDB; Q641B9; -.
DR   SMR; Q641B9; -.
DR   STRING; 8355.Q641B9; -.
DR   DNASU; 447745; -.
DR   GeneID; 447745; -.
DR   KEGG; xla:447745; -.
DR   CTD; 447745; -.
DR   OMA; SACFWKV; -.
DR   OrthoDB; 1565115at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 447745; Expressed in spleen and 19 other tissues.
DR   GO; GO:0005885; C:Arp2/3 protein complex; ISS:UniProtKB.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0035861; C:site of double-strand break; ISS:UniProtKB.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:InterPro.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   Gene3D; 1.25.40.190; -; 1.
DR   InterPro; IPR006789; ARPC5.
DR   InterPro; IPR036743; ARPC5_sf.
DR   PANTHER; PTHR12644; PTHR12644; 1.
DR   Pfam; PF04699; P16-Arc; 1.
DR   PIRSF; PIRSF039096; p16-ARC; 1.
DR   SUPFAM; SSF69103; SSF69103; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cell projection; Cytoplasm; Cytoskeleton; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..150
FT                   /note="Actin-related protein 2/3 complex subunit 5-C"
FT                   /id="PRO_0000445566"
FT   REGION          21..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..35
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   150 AA;  16453 MW;  39723E7DC5CD6561 CRC64;
     MAKNTVSARF RKVDVDEYDE NKFVDEEEAG EGQQGPDEGE VDSAIRGGNM MGALQAVLKN
     PPINTKNQSA KDQAEHLVLK VLISFKANEI EKAVQSLDKN SMDLLMKYIY KGFESPSDNS
     SAVLLQWHEK ALAVAGVGSI VRVLTARKTV