ID   APC5_ARATH              Reviewed;         916 AA.
AC   Q8H1U4; Q67YV2; Q9SHK3;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Anaphase-promoting complex subunit 5;
DE   AltName: Full=Cyclosome subunit 5;
GN   Name=APC5; OrderedLocusNames=At1g06590; ORFNames=F12K11.7;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   REVIEW, AND GENE FAMILY.
RX   PubMed=21087491; DOI=10.1186/1471-2229-10-254;
RA   Lima M.D.F., Eloy N.B., Pegoraro C., Sagit R., Rojas C., Bretz T.,
RA   Vargas L., Elofsson A., de Oliveira A.C., Hemerly A.S., Ferreira P.C.G.;
RT   "Genomic evolution and complexity of the Anaphase-promoting Complex (APC)
RT   in land plants.";
RL   BMC Plant Biol. 10:254-254(2010).
RN   [6]
RP   INTERACTION WITH PYM.
RX   PubMed=22167059; DOI=10.1105/tpc.111.091793;
RA   Heyman J., Van den Daele H., De Wit K., Boudolf V., Berckmans B.,
RA   Verkest A., Alvim Kamei C.L., De Jaeger G., Koncz C., De Veylder L.;
RT   "Arabidopsis ULTRAVIOLET-B-INSENSITIVE4 maintains cell division activity by
RT   temporal inhibition of the anaphase-promoting complex/cyclosome.";
RL   Plant Cell 23:4394-4410(2011).
CC   -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC       (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex
CC       that controls progression through mitosis and the G1 phase of the cell
CC       cycle. The APC/C complex controls several key steps in the cell cycle
CC       by mediating ubiquitination and subsequent degradation of target
CC       proteins such as cyclins. The APC/C complex is required for the female
CC       gametophyte development and is involved in several aspect of
CC       development by controlling cell division and cell elongation. Involved
CC       in the control of endoreduplication (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: The APC/C is composed of at least 10 subunits (By similarity).
CC       Interacts with PYM. {ECO:0000250, ECO:0000269|PubMed:22167059}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the APC5 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF24811.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Arabidopsis APC/C subunits;
CC       URL="http://personal.rhul.ac.uk/ujba/110/apc/APC.htm";
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DR   EMBL; AC007592; AAF24811.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE28009.1; -; Genomic_DNA.
DR   EMBL; AY138229; AAN10197.1; -; mRNA.
DR   EMBL; AK176366; BAD44129.1; -; mRNA.
DR   PIR; C86201; C86201.
DR   RefSeq; NP_172146.2; NM_100538.5.
DR   AlphaFoldDB; Q8H1U4; -.
DR   SMR; Q8H1U4; -.
DR   BioGRID; 22411; 10.
DR   IntAct; Q8H1U4; 10.
DR   STRING; 3702.AT1G06590.1; -.
DR   iPTMnet; Q8H1U4; -.
DR   PaxDb; Q8H1U4; -.
DR   PRIDE; Q8H1U4; -.
DR   ProteomicsDB; 244476; -.
DR   DNASU; 837170; -.
DR   EnsemblPlants; AT1G06590.1; AT1G06590.1; AT1G06590.
DR   GeneID; 837170; -.
DR   Gramene; AT1G06590.1; AT1G06590.1; AT1G06590.
DR   KEGG; ath:AT1G06590; -.
DR   Araport; AT1G06590; -.
DR   TAIR; locus:2009150; AT1G06590.
DR   eggNOG; KOG4322; Eukaryota.
DR   HOGENOM; CLU_006214_0_0_1; -.
DR   InParanoid; Q8H1U4; -.
DR   OMA; YAPRSHM; -.
DR   OrthoDB; 240631at2759; -.
DR   PhylomeDB; Q8H1U4; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q8H1U4; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q8H1U4; baseline and differential.
DR   Genevisible; Q8H1U4; AT.
DR   GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IBA:GO_Central.
DR   GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR   InterPro; IPR037679; Apc5.
DR   InterPro; IPR026000; Apc5_dom.
DR   PANTHER; PTHR12830; PTHR12830; 1.
DR   Pfam; PF12862; ANAPC5; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Mitosis; Nucleus; Reference proteome;
KW   Ubl conjugation pathway.
FT   CHAIN           1..916
FT                   /note="Anaphase-promoting complex subunit 5"
FT                   /id="PRO_0000396842"
FT   REGION          234..255
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        861
FT                   /note="E -> G (in Ref. 4; BAD44129)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   916 AA;  101040 MW;  39201CEDB32DE11C CRC64;
     MAGLTRTAGA FAVTPHKISV CILLQIYAPS AQMSLPFPFS SVAQHNRLGL YLLSLTKSCD
     DIFEPKLEKL INQLREVGEE MDAWLTDHLT NRFSSLASPD DLLNFFNDMR GILGSLDSGV
     VQDDQIILDP NSNLGMFVRR CILAFNLLSF EGVCHLFSSI EDYCKEAHSS FAQFGAPNNN
     LESLIQYDQM DMENYAMDKP TEEIEFQKTA SGIVPFHLHT PDSLMKATEG LLHNRKETSR
     TSKKDTEATP VARASTSTLE ESLVDESLFL RTNLQIQGFL MEQADAIEIH GSSSSFSSSS
     IESFLDQLQK LAPELHRVHF LRYLNKLHSD DYFAALDNLL RYFDYSAGTE GFDLVPPSTG
     CSMYGRYEIG LLCLGMMHFR FGHPNLALEV LTEAVRVSQQ LSNDTCLAYT LAAMSNLLSE
     MGIASTSGVL GSSYSPVTST ASSLSVQQRV YILLKESLRR ADSLKLRRLV ASNHLAMAKF
     ELMHVQRPLL SFGPKASMRH KTCPVSVCKE IRLGAHLISD FSSESSTMTI DGSLSSAWLK
     DLQKPWGPPV ISPDSGSRKS STFFQLCDHL VSIPGSVSQL IGASYLLRAT SWELYGSAPM
     ARMNTLVYAT LFGDSSSSSD AELAYLKLIQ HLALYKGYKD AFAALKVAEE KFLTVSKSKV
     LLLKLQLLHE RALHCGNLKL AQRICNELGG LASTAMGVDM ELKVEASLRE ARTLLAAKQY
     SQAANVAHSL FCTCHKFNLQ IEKASVLLLL AEIHKKSGNA VLGLPYALAS ISFCQSFNLD
     LLKASATLTL AELWLGLGSN HTKRALDLLH GAFPMILGHG GLELRARAYI FEANCYLSDP
     SSSVSTDSDT VLDSLRQASD ELQALEYHEL AAEASYLMAM VYDKLGRLDE REEAASLFKK
     HIIALENPQD VEQNMA