ID   APC5_CHICK              Reviewed;         756 AA.
AC   Q5ZKK3;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Anaphase-promoting complex subunit 5;
DE            Short=APC5;
DE   AltName: Full=Cyclosome subunit 5;
GN   Name=ANAPC5; ORFNames=RCJMB04_10e17;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC       (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC       progression through mitosis and the G1 phase of the cell cycle. The
CC       APC/C complex acts by mediating ubiquitination and subsequent
CC       degradation of target proteins: it mainly mediates the formation of
CC       'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC       formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By
CC       similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: The APC/C is composed of at least 12 subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UJX4}.
CC       Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9UJX4}.
CC   -!- SIMILARITY: Belongs to the APC5 family. {ECO:0000305}.
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DR   EMBL; AJ720081; CAG31740.1; -; mRNA.
DR   RefSeq; NP_001006187.1; NM_001006187.1.
DR   AlphaFoldDB; Q5ZKK3; -.
DR   SMR; Q5ZKK3; -.
DR   STRING; 9031.ENSGALP00000038461; -.
DR   PaxDb; Q5ZKK3; -.
DR   GeneID; 416842; -.
DR   KEGG; gga:416842; -.
DR   CTD; 51433; -.
DR   VEuPathDB; HostDB:geneid_416842; -.
DR   eggNOG; KOG4322; Eukaryota.
DR   InParanoid; Q5ZKK3; -.
DR   OrthoDB; 240631at2759; -.
DR   PhylomeDB; Q5ZKK3; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q5ZKK3; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005819; C:spindle; ISS:UniProtKB.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IBA:GO_Central.
DR   GO; GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR037679; Apc5.
DR   InterPro; IPR026000; Apc5_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR12830; PTHR12830; 1.
DR   Pfam; PF12862; ANAPC5; 1.
DR   SUPFAM; SSF48452; SSF48452; 2.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Mitosis; Nucleus;
KW   Phosphoprotein; Reference proteome; Repeat; TPR repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..756
FT                   /note="Anaphase-promoting complex subunit 5"
FT                   /id="PRO_0000307378"
FT   REPEAT          301..334
FT                   /note="TPR 1"
FT   REPEAT          522..555
FT                   /note="TPR 2"
FT   REPEAT          581..614
FT                   /note="TPR 3"
FT   REPEAT          678..711
FT                   /note="TPR 4"
SQ   SEQUENCE   756 AA;  85306 MW;  72F4A46EE8486ADE CRC64;
     MASVHESLYF NPMMTNGVVH ANVFGIKDWV TPYKMALLVL LSELGRAGSQ LDQLERRRLN
     RLLLPLLQGP DMPLSRLRKA IEECCPNLAG SVHIRLKLIA EGELKDMEQF FDDLSDSFSG
     TEPEVHKTSV IGLFLRHMIL AYNKLSFSQV YKLYTALQQY FLNDEKKCGI DENDMELTNT
     EELDGKMEKE ELDVPLREEE ISCSGPLSQK QAEYFLSQQA SLLKNDETKA LSPVSLQKEL
     NNLLKFNPDF AEAHYLSYLN SLRVHDVFSS THSLLHYFDR LILTGAESKS NGDEGYGRSL
     RYAALNLAAL HCRFGHYQQA ELALQEAIRI AQESNDHVCL QHCLSWLHIS EQKIFDSCVL
     LEHSVNKSLH FGLPYLASLG IQSLVQQRAF AGKAANKLMD ALKDSDLLHW KHSLSELIDI
     SIAQKTAIWR LYGRSTMALQ QAQTLLSMNS LEAVNVGVQQ NNTEAFAVVL CHLAELHAEQ
     GYFAAASEIL KHLKERFPPN SQHAQLWMLF DQKIQFERAM NDGRYHIADS LVAGITALNS
     IEGMYRKAIV LKAQNQMLEA HKLLQKLLIH CQEIKNTEIV ISVLLSVAEL YWRSSCHTIA
     LPVLLQALAF SREYSLQYLA SETVLNLAFS QLILGVPEQV LNILHMAIEP GLAHGAVLDK
     GCAMFLVAKC QVASTASYSQ QKKAEALESA ILNLNEAKTY LAKVDCKEQL RDVLYFQARL
     FHTLGKTQER NKCAMLFRQL HQELPAHGVP LINAFK