IDLC_HUMAN
ID IDLC_HUMAN Reviewed; 258 AA.
AC O14645; A8K387; B4DHN6; Q05BL9; Q5HYE2; Q5TGH0; Q7L0I5;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Axonemal dynein light intermediate polypeptide 1 {ECO:0000305};
DE AltName: Full=Inner dynein arm light chain, axonemal;
DE AltName: Full=hp28;
GN Name=DNALI1 {ECO:0000312|HGNC:HGNC:14353};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Fetal liver, Fetal lung, and Spleen;
RX PubMed=9284741; DOI=10.1210/jcem.82.9.4242;
RA Kastury K., Taylor W.E., Shen R., Arver S., Gutierrez M., Fisher C.E.,
RA Coucke P.J., Van Hauwe P., Van Camp G., Bhasin S.;
RT "Complementary deoxyribonucleic acid cloning and characterization of a
RT putative human axonemal dynein light chain gene.";
RL J. Clin. Endocrinol. Metab. 82:3047-3053(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Caudate nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Cervix;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP SUBCELLULAR LOCATION.
RX PubMed=27120127; DOI=10.1002/humu.23005;
RA Jeanson L., Thomas L., Copin B., Coste A., Sermet-Gaudelus I.,
RA Dastot-Le Moal F., Duquesnoy P., Montantin G., Collot N., Tissier S.,
RA Papon J.F., Clement A., Louis B., Escudier E., Amselem S., Legendre M.;
RT "Mutations in GAS8, a gene encoding a nexin-dynein regulatory complex
RT subunit, cause primary ciliary dyskinesia with axonemal disorganization.";
RL Hum. Mutat. 37:776-785(2016).
RN [7]
RP INTERACTION WITH CFAP45.
RX PubMed=33139725; DOI=10.1038/s41467-020-19113-0;
RA Dougherty G.W., Mizuno K., Noethe-Menchen T., Ikawa Y., Boldt K.,
RA Ta-Shma A., Aprea I., Minegishi K., Pang Y.P., Pennekamp P., Loges N.T.,
RA Raidt J., Hjeij R., Wallmeier J., Mussaffi H., Perles Z., Elpeleg O.,
RA Rabert F., Shiratori H., Letteboer S.J., Horn N., Young S., Struenker T.,
RA Stumme F., Werner C., Olbrich H., Takaoka K., Ide T., Twan W.K.,
RA Biebach L., Grosse-Onnebrink J., Klinkenbusch J.A., Praveen K.,
RA Bracht D.C., Hoeben I.M., Junger K., Guetzlaff J., Cindric S., Aviram M.,
RA Kaiser T., Memari Y., Dzeja P.P., Dworniczak B., Ueffing M., Roepman R.,
RA Bartscherer K., Katsanis N., Davis E.E., Amirav I., Hamada H., Omran H.;
RT "CFAP45 deficiency causes situs abnormalities and asthenospermia by
RT disrupting an axonemal adenine nucleotide homeostasis module.";
RL Nat. Commun. 11:5520-5520(2020).
RN [8]
RP VARIANT [LARGE SCALE ANALYSIS] MET-120.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
RN [9]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=31178125; DOI=10.1016/j.ajhg.2019.04.015;
RA Whitfield M., Thomas L., Bequignon E., Schmitt A., Stouvenel L.,
RA Montantin G., Tissier S., Duquesnoy P., Copin B., Chantot S., Dastot F.,
RA Faucon C., Barbotin A.L., Loyens A., Siffroi J.P., Papon J.F., Escudier E.,
RA Amselem S., Mitchell V., Toure A., Legendre M.;
RT "Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm
RT Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.";
RL Am. J. Hum. Genet. 105:198-212(2019).
CC -!- FUNCTION: May play a dynamic role in flagellar motility.
CC -!- SUBUNIT: Interacts with CFAP45 (PubMed:33139725). Interacts with
CC DYNC1H1 (By similarity). {ECO:0000250|UniProtKB:Q8BVN8,
CC ECO:0000269|PubMed:33139725}.
CC -!- INTERACTION:
CC O14645; Q96MA6: AK8; NbExp=3; IntAct=EBI-395638, EBI-8466265;
CC O14645; Q99996-3: AKAP9; NbExp=3; IntAct=EBI-395638, EBI-11022349;
CC O14645; P13196: ALAS1; NbExp=3; IntAct=EBI-395638, EBI-3905054;
CC O14645; Q6LES2: ANXA4; NbExp=3; IntAct=EBI-395638, EBI-10250835;
CC O14645; P13928: ANXA8; NbExp=3; IntAct=EBI-395638, EBI-2556915;
CC O14645; O00203: AP3B1; NbExp=3; IntAct=EBI-395638, EBI-1044383;
CC O14645; P05067: APP; NbExp=3; IntAct=EBI-395638, EBI-77613;
CC O14645; Q96DX5-3: ASB9; NbExp=3; IntAct=EBI-395638, EBI-25843552;
CC O14645; Q96FT7-4: ASIC4; NbExp=3; IntAct=EBI-395638, EBI-9089489;
CC O14645; P15313: ATP6V1B1; NbExp=3; IntAct=EBI-395638, EBI-2891281;
CC O14645; P54687-4: BCAT1; NbExp=3; IntAct=EBI-395638, EBI-25834445;
CC O14645; Q14457: BECN1; NbExp=3; IntAct=EBI-395638, EBI-949378;
CC O14645; Q9NNX6-10: CD209; NbExp=3; IntAct=EBI-395638, EBI-12300031;
CC O14645; Q7Z7K6: CENPV; NbExp=3; IntAct=EBI-395638, EBI-1210604;
CC O14645; Q8WUX9: CHMP7; NbExp=3; IntAct=EBI-395638, EBI-749253;
CC O14645; Q9UJU6: DBNL; NbExp=3; IntAct=EBI-395638, EBI-751783;
CC O14645; Q8WTU0: DDI1; NbExp=3; IntAct=EBI-395638, EBI-748248;
CC O14645; A0A024RCP2: DOM3Z; NbExp=3; IntAct=EBI-395638, EBI-25847826;
CC O14645; Q86TI2-2: DPP9; NbExp=3; IntAct=EBI-395638, EBI-21529239;
CC O14645; Q14117: DPYS; NbExp=3; IntAct=EBI-395638, EBI-12275416;
CC O14645; A0AVK6: E2F8; NbExp=3; IntAct=EBI-395638, EBI-7779316;
CC O14645; O00303: EIF3F; NbExp=3; IntAct=EBI-395638, EBI-711990;
CC O14645; Q9UBQ5: EIF3K; NbExp=4; IntAct=EBI-395638, EBI-354344;
CC O14645; Q6NXG1: ESRP1; NbExp=3; IntAct=EBI-395638, EBI-10213520;
CC O14645; Q6NXG1-3: ESRP1; NbExp=3; IntAct=EBI-395638, EBI-21567429;
CC O14645; Q49AJ0-4: FAM135B; NbExp=3; IntAct=EBI-395638, EBI-25835236;
CC O14645; Q9NSA1: FGF21; NbExp=3; IntAct=EBI-395638, EBI-3909329;
CC O14645; P06241-3: FYN; NbExp=3; IntAct=EBI-395638, EBI-10691738;
CC O14645; Q06547-3: GABPB1; NbExp=3; IntAct=EBI-395638, EBI-9088619;
CC O14645; Q9BRX5: GINS3; NbExp=3; IntAct=EBI-395638, EBI-2857315;
CC O14645; Q96IJ6: GMPPA; NbExp=3; IntAct=EBI-395638, EBI-750953;
CC O14645; P42858: HTT; NbExp=15; IntAct=EBI-395638, EBI-466029;
CC O14645; P80217-2: IFI35; NbExp=3; IntAct=EBI-395638, EBI-12823003;
CC O14645; Q8NA54: IQUB; NbExp=3; IntAct=EBI-395638, EBI-10220600;
CC O14645; Q13352: ITGB3BP; NbExp=3; IntAct=EBI-395638, EBI-712105;
CC O14645; Q9UIH9: KLF15; NbExp=3; IntAct=EBI-395638, EBI-2796400;
CC O14645; Q13887: KLF5; NbExp=3; IntAct=EBI-395638, EBI-2696013;
CC O14645; Q6DKI2: LGALS9C; NbExp=3; IntAct=EBI-395638, EBI-9088829;
CC O14645; Q9BV99: LRRC61; NbExp=3; IntAct=EBI-395638, EBI-2350424;
CC O14645; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-395638, EBI-741037;
CC O14645; Q8N6F8: METTL27; NbExp=3; IntAct=EBI-395638, EBI-8487781;
CC O14645; A6NI15: MSGN1; NbExp=3; IntAct=EBI-395638, EBI-11991020;
CC O14645; P02795: MT2A; NbExp=3; IntAct=EBI-395638, EBI-996616;
CC O14645; Q96FW1: OTUB1; NbExp=3; IntAct=EBI-395638, EBI-1058491;
CC O14645; Q6GQQ9-2: OTUD7B; NbExp=3; IntAct=EBI-395638, EBI-25830200;
CC O14645; Q9ULW8: PADI3; NbExp=3; IntAct=EBI-395638, EBI-10488185;
CC O14645; Q9BPZ3: PAIP2; NbExp=3; IntAct=EBI-395638, EBI-2957445;
CC O14645; P57054: PIGP; NbExp=3; IntAct=EBI-395638, EBI-17630288;
CC O14645; Q6ZMI0-5: PPP1R21; NbExp=3; IntAct=EBI-395638, EBI-25835994;
CC O14645; Q96LA8: PRMT6; NbExp=2; IntAct=EBI-395638, EBI-912440;
CC O14645; P47736: RAP1GAP; NbExp=3; IntAct=EBI-395638, EBI-722307;
CC O14645; Q96EN9: REX1BD; NbExp=3; IntAct=EBI-395638, EBI-745810;
CC O14645; P47804-3: RGR; NbExp=3; IntAct=EBI-395638, EBI-25834767;
CC O14645; Q96EP0: RNF31; NbExp=3; IntAct=EBI-395638, EBI-948111;
CC O14645; Q8IUQ4: SIAH1; NbExp=3; IntAct=EBI-395638, EBI-747107;
CC O14645; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-395638, EBI-358489;
CC O14645; Q7Z6I5: SPATA12; NbExp=3; IntAct=EBI-395638, EBI-10696971;
CC O14645; Q9BZK7: TBL1XR1; NbExp=3; IntAct=EBI-395638, EBI-765729;
CC O14645; Q3YBR2: TBRG1; NbExp=3; IntAct=EBI-395638, EBI-2800552;
CC O14645; Q8WTV1: THAP3; NbExp=3; IntAct=EBI-395638, EBI-17438286;
CC O14645; Q8IUR5-4: TMTC1; NbExp=3; IntAct=EBI-395638, EBI-9089156;
CC O14645; Q12888: TP53BP1; NbExp=3; IntAct=EBI-395638, EBI-396540;
CC O14645; Q86WV8: TSC1; NbExp=3; IntAct=EBI-395638, EBI-12806590;
CC O14645; Q6PID6: TTC33; NbExp=3; IntAct=EBI-395638, EBI-2555404;
CC O14645; P49459: UBE2A; NbExp=3; IntAct=EBI-395638, EBI-2339348;
CC O14645; P58304: VSX2; NbExp=3; IntAct=EBI-395638, EBI-6427899;
CC O14645; Q9BRX9: WDR83; NbExp=3; IntAct=EBI-395638, EBI-7705033;
CC O14645; Q86U90: YRDC; NbExp=3; IntAct=EBI-395638, EBI-21659356;
CC O14645; Q96JL9-2: ZNF333; NbExp=3; IntAct=EBI-395638, EBI-25835852;
CC O14645; Q96MN9-2: ZNF488; NbExp=3; IntAct=EBI-395638, EBI-25831733;
CC O14645; Q2QGD7: ZXDC; NbExp=3; IntAct=EBI-395638, EBI-1538838;
CC O14645; B7Z3E8; NbExp=3; IntAct=EBI-395638, EBI-25831617;
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000269|PubMed:27120127}. Cell projection, cilium, flagellum
CC {ECO:0000269|PubMed:31178125}. Dynein axonemal particle
CC {ECO:0000250|UniProtKB:Q6GN86}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q8BVN8}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O14645-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O14645-2; Sequence=VSP_056965, VSP_056966;
CC -!- TISSUE SPECIFICITY: Expressed in many tissues. A smaller 0.9 kb and a
CC larger 2.5 kb transcripts were detected at the highest level in the
CC testis, at medium levels in the prostate, heart, liver, lung and
CC pancreas, at low levels in the ovary, skeletal muscle and small
CC intestine. Not detected in spleen, colon epithelium, thymus or
CC peripheral blood leukocytes. The 0.9 kb transcript is expressed at a
CC 20-fold higher level than the 2.5 kb transcript in the testis.
CC Expressed in spermatozoa and airway epithelial cells (at protein level)
CC (PubMed:31178125). {ECO:0000269|PubMed:31178125}.
CC -!- SIMILARITY: Belongs to the inner dynein arm light chain family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB69193.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAI46082.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF006386; AAB69193.1; ALT_FRAME; mRNA.
DR EMBL; AK295199; BAG58198.1; -; mRNA.
DR EMBL; AK290502; BAF83191.1; -; mRNA.
DR EMBL; BX647913; CAI46082.1; ALT_INIT; mRNA.
DR EMBL; AL034379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC039074; AAH39074.1; -; mRNA.
DR EMBL; BC046117; AAH46117.1; -; mRNA.
DR CCDS; CCDS420.1; -. [O14645-1]
DR RefSeq; NP_003453.2; NM_003462.3. [O14645-1]
DR RefSeq; XP_005271229.1; XM_005271172.2.
DR AlphaFoldDB; O14645; -.
DR SMR; O14645; -.
DR BioGRID; 113577; 17.
DR IntAct; O14645; 84.
DR MINT; O14645; -.
DR STRING; 9606.ENSP00000296218; -.
DR iPTMnet; O14645; -.
DR PhosphoSitePlus; O14645; -.
DR BioMuta; DNALI1; -.
DR EPD; O14645; -.
DR MassIVE; O14645; -.
DR PaxDb; O14645; -.
DR PeptideAtlas; O14645; -.
DR PRIDE; O14645; -.
DR ProteomicsDB; 4231; -.
DR ProteomicsDB; 48141; -. [O14645-1]
DR Antibodypedia; 31735; 205 antibodies from 23 providers.
DR DNASU; 7802; -.
DR Ensembl; ENST00000652629.1; ENSP00000498620.1; ENSG00000163879.11. [O14645-1]
DR GeneID; 7802; -.
DR KEGG; hsa:7802; -.
DR MANE-Select; ENST00000652629.1; ENSP00000498620.1; NM_003462.5; NP_003453.3.
DR UCSC; uc001cbj.3; human. [O14645-1]
DR CTD; 7802; -.
DR DisGeNET; 7802; -.
DR GeneCards; DNALI1; -.
DR HGNC; HGNC:14353; DNALI1.
DR HPA; ENSG00000163879; Tissue enhanced (fallopian).
DR MIM; 602135; gene.
DR neXtProt; NX_O14645; -.
DR OpenTargets; ENSG00000163879; -.
DR PharmGKB; PA38381; -.
DR VEuPathDB; HostDB:ENSG00000163879; -.
DR eggNOG; KOG4001; Eukaryota.
DR GeneTree; ENSGT00390000003012; -.
DR HOGENOM; CLU_072652_0_0_1; -.
DR InParanoid; O14645; -.
DR OrthoDB; 1375694at2759; -.
DR PhylomeDB; O14645; -.
DR TreeFam; TF314891; -.
DR PathwayCommons; O14645; -.
DR SignaLink; O14645; -.
DR SIGNOR; O14645; -.
DR BioGRID-ORCS; 7802; 8 hits in 1066 CRISPR screens.
DR ChiTaRS; DNALI1; human.
DR GenomeRNAi; 7802; -.
DR Pharos; O14645; Tbio.
DR PRO; PR:O14645; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; O14645; protein.
DR Bgee; ENSG00000163879; Expressed in right uterine tube and 130 other tissues.
DR ExpressionAtlas; O14645; baseline and differential.
DR Genevisible; O14645; HS.
DR GO; GO:0097729; C:9+2 motile cilium; IDA:GO_Central.
DR GO; GO:0005930; C:axoneme; IDA:UniProtKB.
DR GO; GO:0005929; C:cilium; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:BHF-UCL.
DR GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0030175; C:filopodium; IBA:GO_Central.
DR GO; GO:0031514; C:motile cilium; IDA:UniProtKB.
DR GO; GO:0036126; C:sperm flagellum; IDA:UniProtKB.
DR GO; GO:0045504; F:dynein heavy chain binding; IBA:GO_Central.
DR InterPro; IPR019347; Axonemal_dynein_light_chain.
DR PANTHER; PTHR13183; PTHR13183; 1.
DR Pfam; PF10211; Ax_dynein_light; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Cilium; Coiled coil; Cytoplasm;
KW Dynein; Flagellum; Motor protein; Reference proteome.
FT CHAIN 1..258
FT /note="Axonemal dynein light intermediate polypeptide 1"
FT /id="PRO_0000114675"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 176..255
FT /evidence="ECO:0000255"
FT COMPBIAS 40..55
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..6
FT /note="MIPPAD -> MPYYPQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056965"
FT VAR_SEQ 7..132
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056966"
FT VARIANT 65
FT /note="A -> V (in dbSNP:rs11749)"
FT /id="VAR_014473"
FT VARIANT 120
FT /note="I -> M (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs1266159589)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035701"
FT CONFLICT 54
FT /note="S -> P (in Ref. 3; CAI46082)"
FT /evidence="ECO:0000305"
FT CONFLICT 76
FT /note="R -> K (in Ref. 2; BAF83191)"
FT /evidence="ECO:0000305"
FT CONFLICT 152
FT /note="R -> Q (in Ref. 1; AAB69193)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 258 AA; 29662 MW; 5E95F15FE4476BF7 CRC64;
MIPPADSLLK YDTPVLVSRN TEKRSPKARL LKVSPQQPGP SGSAPQPPKT KLPSTPCVPD
PTKQAEEILN AILPPREWVE DTQLWIQQVS STPSTRMDVV HLQEQLDLKL QQRQARETGI
CPVRRELYSQ CFDELIREVT INCAERGLLL LRVRDEIRMT IAAYQTLYES SVAFGMRKAL
QAEQGKSDME RKIAELETEK RDLERQVNEQ KAKCEATEKR ESERRQVEEK KHNEEIQFLK
RTNQQLKAQL EGIIAPKK
