IDLC_MOUSE
ID IDLC_MOUSE Reviewed; 258 AA.
AC Q8BVN8; Q0IIN3; Q147V3;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Axonemal dynein light intermediate polypeptide 1 {ECO:0000305};
DE AltName: Full=Inner dynein arm light chain, axonemal;
GN Name=Dnali1 {ECO:0000312|MGI:MGI:1922813};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP INTERACTION WITH DYNC1H1.
RX PubMed=16496424; DOI=10.1002/mrd.20475;
RA Rashid S., Breckle R., Hupe M., Geisler S., Doerwald N., Neesen J.;
RT "The murine Dnali1 gene encodes a flagellar protein that interacts with the
RT cytoplasmic dynein heavy chain 1.";
RL Mol. Reprod. Dev. 73:784-794(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a dynamic role in flagellar motility. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CFAP45 (By similarity). Interacts with DYNC1H1
CC (PubMed:16496424). {ECO:0000250|UniProtKB:O14645,
CC ECO:0000269|PubMed:16496424}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000269|PubMed:16496424}. Cell projection, cilium, flagellum
CC {ECO:0000269|PubMed:16496424}. Dynein axonemal particle
CC {ECO:0000250|UniProtKB:Q6GN86}. Cytoplasm
CC {ECO:0000269|PubMed:16496424}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in the testis, also
CC detected at lower levels in several tissues expressing cilia
CC (PubMed:16496424). Strongly expressed in elongating spermatid cells (at
CC protein level) (PubMed:16496424). {ECO:0000269|PubMed:16496424}.
CC -!- SIMILARITY: Belongs to the inner dynein arm light chain family.
CC {ECO:0000305}.
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DR EMBL; AK077109; BAC36617.1; -; mRNA.
DR EMBL; BC122552; AAI22553.1; -; mRNA.
DR EMBL; BC118619; AAI18620.1; -; mRNA.
DR CCDS; CCDS18635.1; -.
DR RefSeq; NP_780432.1; NM_175223.4.
DR AlphaFoldDB; Q8BVN8; -.
DR SMR; Q8BVN8; -.
DR STRING; 10090.ENSMUSP00000047783; -.
DR iPTMnet; Q8BVN8; -.
DR PhosphoSitePlus; Q8BVN8; -.
DR MaxQB; Q8BVN8; -.
DR PaxDb; Q8BVN8; -.
DR PRIDE; Q8BVN8; -.
DR ProteomicsDB; 273091; -.
DR Antibodypedia; 31735; 205 antibodies from 23 providers.
DR DNASU; 75563; -.
DR Ensembl; ENSMUST00000036383; ENSMUSP00000047783; ENSMUSG00000042707.
DR GeneID; 75563; -.
DR KEGG; mmu:75563; -.
DR UCSC; uc008urp.1; mouse.
DR CTD; 7802; -.
DR MGI; MGI:1922813; Dnali1.
DR VEuPathDB; HostDB:ENSMUSG00000042707; -.
DR eggNOG; KOG4001; Eukaryota.
DR GeneTree; ENSGT00390000003012; -.
DR HOGENOM; CLU_072652_0_0_1; -.
DR InParanoid; Q8BVN8; -.
DR OMA; INCTERG; -.
DR OrthoDB; 1375694at2759; -.
DR PhylomeDB; Q8BVN8; -.
DR TreeFam; TF314891; -.
DR BioGRID-ORCS; 75563; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q8BVN8; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8BVN8; protein.
DR Bgee; ENSMUSG00000042707; Expressed in seminiferous tubule of testis and 46 other tissues.
DR ExpressionAtlas; Q8BVN8; baseline and differential.
DR Genevisible; Q8BVN8; MM.
DR GO; GO:0097729; C:9+2 motile cilium; EXP:MGI.
DR GO; GO:0005930; C:axoneme; IDA:MGI.
DR GO; GO:0097546; C:ciliary base; EXP:MGI.
DR GO; GO:0005929; C:cilium; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0030175; C:filopodium; IDA:MGI.
DR GO; GO:0031514; C:motile cilium; IDA:UniProtKB.
DR GO; GO:0036126; C:sperm flagellum; IDA:UniProtKB.
DR GO; GO:0045504; F:dynein heavy chain binding; IPI:MGI.
DR GO; GO:0003341; P:cilium movement; IC:MGI.
DR InterPro; IPR019347; Axonemal_dynein_light_chain.
DR PANTHER; PTHR13183; PTHR13183; 1.
DR Pfam; PF10211; Ax_dynein_light; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Dynein; Flagellum;
KW Motor protein; Reference proteome.
FT CHAIN 1..258
FT /note="Axonemal dynein light intermediate polypeptide 1"
FT /id="PRO_0000114677"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 176..255
FT /evidence="ECO:0000255"
FT CONFLICT 132
FT /note="F -> FE (in Ref. 3; AAI18620)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 258 AA; 29680 MW; A04932BC6FA90676 CRC64;
MIPPADSLLK YDTPVLVSRN TEKRSPTARP LKVTIQQPGP SSTSPQPPKA KLPSTSCVPD
PTKQAEEILN AILPPREWVE DTQLWIQQVS STPSTRMDVV HLQEQLDLKL QQRQARETGI
CPVRRELYSQ CFDELIREVT INCAERGLLL LRVRDEIHMT IAAYQTLYES SVAFGMRKAL
QAEQGKSDME RKITELETEK RDLERQVNEQ KAKCEATEKR ESERRQVEEK KHNEEIQFLK
RTNQQLKAQL EGIIAPKK
