IDLC_XENLA
ID IDLC_XENLA Reviewed; 254 AA.
AC Q6GN86;
DT 07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Axonemal dynein light intermediate polypeptide 1 {ECO:0000305};
DE AltName: Full=Inner dynein arm light chain, axonemal;
GN Name=dnali1 {ECO:0000312|Xenbase:XB-GENE-866556};
GN ORFNames=XELAEV_18015190mg {ECO:0000312|EMBL:OCT92136.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000312|EMBL:AAH73629.1};
RN [1] {ECO:0000312|EMBL:AAH73629.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH73629.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|Proteomes:UP000186698}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J {ECO:0000312|Proteomes:UP000186698};
RX PubMed=27762356; DOI=10.1038/nature19840;
RA Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S.,
RA Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J., Quigley I.,
RA Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B., Simakov O.,
RA Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T., Watanabe M.,
RA Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S., van Kruijsbergen I.,
RA Shu S., Carlson J., Kinoshita T., Ohta Y., Mawaribuchi S., Jenkins J.,
RA Grimwood J., Schmutz J., Mitros T., Mozaffari S.V., Suzuki Y., Haramoto Y.,
RA Yamamoto T.S., Takagi C., Heald R., Miller K., Haudenschild C., Kitzman J.,
RA Nakayama T., Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V.,
RA Karimi K., Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W.,
RA Shendure J., DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M.,
RA Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y., Veenstra G.J.,
RA Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.;
RT "Genome evolution in the allotetraploid frog Xenopus laevis.";
RL Nature 538:336-343(2016).
RN [3] {ECO:0000312|EMBL:OCT92136.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=J {ECO:0000312|EMBL:OCT92136.1};
RC TISSUE=Blood {ECO:0000312|EMBL:OCT92136.1};
RA Session A., Uno Y., Kwon T., Chapman J., Toyoda A., Takahashi S., Fukui A.,
RA Hikosaka A., Putnam N., Stites J., Van Heeringen S., Quigley I., Heinz S.,
RA Hellsten U., Lyons J., Suzuki A., Kondo M., Ogino H., Ochi H.,
RA Bogdanovic O., Lister R., Georgiou G., Paranjpe S., Van Kruijsbergen I.,
RA Mozaffari S., Shu S., Schmutz J., Jenkins J., Grimwood J., Carlson J.,
RA Mitros T., Simakov O., Heald R., Miller K., Haudenschild C., Kuroki Y.,
RA Tanaka T., Michiue T., Watanabe M., Kinoshita T., Ohta Y., Mawaribuchi S.,
RA Suzuki Y., Haramoto Y., Yamamoto T., Takagi C., Kitzman J., Shendure J.,
RA Nakayama T., Izutsu Y., Robert J., Dichmann D., Flajnik M., Houston D.,
RA Marcotte E., Wallingford J., Ito Y., Asashima M., Ueno N., Matsuda Y.,
RA Jan Veenstra G., Fujiyama A., Harland R., Taira M., Rokhsar D.S.;
RT "WGS assembly of Xenopus laevis.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=33263282; DOI=10.7554/elife.58662;
RA Lee C., Cox R.M., Papoulas O., Horani A., Drew K., Devitt C.C., Brody S.L.,
RA Marcotte E.M., Wallingford J.B.;
RT "Functional partitioning of a liquid-like organelle during assembly of
RT axonemal dyneins.";
RL Elife 9:0-0(2020).
CC -!- FUNCTION: May play a dynamic role in flagellar motility.
CC {ECO:0000250|UniProtKB:O14645}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000250|UniProtKB:O14645}. Cell projection, cilium, flagellum
CC {ECO:0000250|UniProtKB:O14645}. Dynein axonemal particle
CC {ECO:0000269|PubMed:33263282}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q8BVN8}.
CC -!- SIMILARITY: Belongs to the inner dynein arm light chain family.
CC {ECO:0000305}.
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DR EMBL; BC073629; AAH73629.1; -; mRNA.
DR EMBL; CM004469; OCT92136.1; -; Genomic_DNA.
DR RefSeq; NP_001085973.1; NM_001092504.1.
DR AlphaFoldDB; Q6GN86; -.
DR SMR; Q6GN86; -.
DR STRING; 8355.Q6GN86; -.
DR DNASU; 444402; -.
DR GeneID; 444402; -.
DR KEGG; xla:444402; -.
DR CTD; 444402; -.
DR Xenbase; XB-GENE-866556; dnali1.S.
DR OMA; INCTERG; -.
DR OrthoDB; 1375694at2759; -.
DR Proteomes; UP000186698; Chromosome 2S.
DR Bgee; 444402; Expressed in testis and 16 other tissues.
DR GO; GO:0120293; C:dynein axonemal particle; IDA:UniProtKB.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR InterPro; IPR019347; Axonemal_dynein_light_chain.
DR PANTHER; PTHR13183; PTHR13183; 1.
DR Pfam; PF10211; Ax_dynein_light; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Dynein; Flagellum;
KW Motor protein; Reference proteome.
FT CHAIN 1..254
FT /note="Axonemal dynein light intermediate polypeptide 1"
FT /id="PRO_0000452445"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 175..245
FT /evidence="ECO:0000255"
FT COMPBIAS 40..54
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 254 AA; 29246 MW; 75650DB39DF8185D CRC64;
MIPPADSLLK HDNPVLISKN TERKSPKSRP LKVSSPQTVL TAPVPPPPKP KTPLLDATKP
AEEILNAILP PREWVENNQL WIQQVSSTPS TRMDVVHLQE ELDMKLQQRQ ARETGICPVR
RELYSQCFDE LIRQVTINCA ERGLLLLRVR DEIHMTISAY QTLYESSVAF GMRKALQAEQ
GKSDMEKRMA DLEMEKKDLE RQVNEQKAKC EAIEKREAER RQVEEKKHAE EIQFLKRTNQ
QLKAQLEGII APKK
