IDM2L_ARATH
ID IDM2L_ARATH Reviewed; 206 AA.
AC Q84K79; Q9ZVL1;
DT 01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Alpha-crystallin domain-containing protein 22.3 {ECO:0000303|PubMed:16531488};
DE Short=AtAcd22.3 {ECO:0000303|PubMed:16531488};
DE AltName: Full=Increased DNA methylation 2-like protein {ECO:0000305};
GN Name=ACD22.3 {ECO:0000303|PubMed:16531488};
GN OrderedLocusNames=At1g54850 {ECO:0000312|Araport:AT1G54850};
GN ORFNames=F14C21.42 {ECO:0000312|EMBL:AAG51117.1},
GN T22H22.24 {ECO:0000312|EMBL:AAC64894.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAO22777.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NOMENCLATURE.
RX PubMed=16531488; DOI=10.1104/pp.105.073841;
RA Ma C., Haslbeck M., Babujee L., Jahn O., Reumann S.;
RT "Identification and characterization of a stress-inducible and a
RT constitutive small heat-shock protein targeted to the matrix of plant
RT peroxisomes.";
RL Plant Physiol. 141:47-60(2006).
RN [5]
RP INDUCTION BY HEAT.
RX PubMed=25002145; DOI=10.1016/j.molcel.2014.06.008;
RA Qian W., Miki D., Lei M., Zhu X., Zhang H., Liu Y., Li Y., Lang Z.,
RA Wang J., Tang K., Liu R., Zhu J.K.;
RT "Regulation of active DNA demethylation by an alpha-crystallin domain
RT protein in Arabidopsis.";
RL Mol. Cell 55:361-371(2014).
RN [6]
RP LACK OF INTERACTION WITH IDM1, AND INDUCTION BY HEAT.
RX PubMed=24920332; DOI=10.1105/tpc.114.126730;
RA Zhao Y., Xie S., Li X., Wang C., Chen Z., Lai J., Gong Z.;
RT "REPRESSOR OF SILENCING5 encodes a member of the small heat shock protein
RT family and is required for DNA demethylation in Arabidopsis.";
RL Plant Cell 26:2660-2675(2014).
CC -!- SUBUNIT: Does not interact with IDM1. {ECO:0000269|PubMed:24920332}.
CC -!- INDUCTION: Not regulated by heat. {ECO:0000269|PubMed:24920332,
CC ECO:0000269|PubMed:25002145}.
CC -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC {ECO:0000255|PROSITE-ProRule:PRU00285, ECO:0000255|RuleBase:RU003616}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC64894.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAG51117.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC005388; AAC64894.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC069144; AAG51117.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE33156.1; -; Genomic_DNA.
DR EMBL; BT002968; AAO22777.1; -; mRNA.
DR EMBL; BT004411; AAO42405.1; -; mRNA.
DR RefSeq; NP_175882.2; NM_104358.2.
DR AlphaFoldDB; Q84K79; -.
DR STRING; 3702.AT1G54850.1; -.
DR iPTMnet; Q84K79; -.
DR PaxDb; Q84K79; -.
DR PRIDE; Q84K79; -.
DR ProteomicsDB; 232198; -.
DR EnsemblPlants; AT1G54850.1; AT1G54850.1; AT1G54850.
DR GeneID; 841924; -.
DR Gramene; AT1G54850.1; AT1G54850.1; AT1G54850.
DR KEGG; ath:AT1G54850; -.
DR Araport; AT1G54850; -.
DR TAIR; locus:2010995; AT1G54850.
DR eggNOG; ENOG502RZDC; Eukaryota.
DR HOGENOM; CLU_093034_0_0_1; -.
DR InParanoid; Q84K79; -.
DR OMA; QNGMREN; -.
DR OrthoDB; 1136142at2759; -.
DR PhylomeDB; Q84K79; -.
DR PRO; PR:Q84K79; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q84K79; baseline and differential.
DR Genevisible; Q84K79; AT.
DR GO; GO:0005730; C:nucleolus; HDA:TAIR.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1901537; P:positive regulation of DNA demethylation; IBA:GO_Central.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR039321; IDM2/3-like.
DR PANTHER; PTHR34661; PTHR34661; 1.
DR Pfam; PF00011; HSP20; 1.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS01031; SHSP; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Stress response.
FT CHAIN 1..206
FT /note="Alpha-crystallin domain-containing protein 22.3"
FT /id="PRO_0000432656"
FT DOMAIN 92..206
FT /note="sHSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 206 AA; 22298 MW; 0E9412C1DDA27585 CRC64;
MRSSSGLNGM RENNSFPDNT RNPQILEVTP LNSMPYIGPV THASMSSNRM NDSVEKVGGP
AMIFLPSDSS SEFSNLISQT KTGVALTGSA AMGKIGLTIG LVDIAESEDS YYFRVALPGV
SRDEKEFSCE IEPDGKIMIK GATTTGEQTV CKHNQIFKML TQNLCPPGHF TINFQLPGPV
SNEEFNGNFG SDGVLEGVVK KVYYED
